IBT-UNAM : Dr. Victor Humberto Bustamante Santillan
Dr. Victor Humberto Bustamante Santillan Grupo
Microbiología Molecular
Líneas de investigación
email: victor @ibt.unam.mx
Teléfonos
Laboratorio +52 (777) 329-1627 red UNAM 27627
- Licenciatura: Químico Bacteriologo y Parasitologo, Escuela Nacional de Ciencias Biologicas-IPN (1991)
Estudiantes Biol. Jelsy Galilea Arellano
Ing. Rodolfo Alfredo Martinez
Monica Bobadilla
Ing. Emily Vanessa Fernández
M.C. Marcos Antonio Valdespino
M.C. Jessica Nava
M.C. Luis Emmanuel Romero
Raúl Bello
Rosa Fernanda Torres
Alexis Téllez
Jaqueline Jimenez
Biol. Fernando Antonio Lévaro
Ing. Seidy Yudith Aguilar
Biol. Michelle Guadalupe Salgado
Publicaciones recientes
Chau,N.Y.E. Perez-Morales,D. Elhenawy,W. Bustamante,V.H. Zhang,Y.E. Coombes,B.K.
2021. (p)ppGpp-dependent regulation of the nucleotide hydrolase PpnN confers complement resistance in Salmonella enterica serovar Typhimurium Infection and Immunity, 89, e00639-20.
Romero-Gonzalez,L.E. Perez-Morales,D. Cortes-Avalos,D. Vazquez-Guerrero,E. Paredes-Hernandez,D.A. Estrada-de Los Santos P. Villa-Tanaca,L. De la Cruz,M.A. Bustamante,V.H. Ibarra,J.A.
2020. The Salmonella Typhimurium InvF-SicA complex is necessary for the transcription of sopB in the absence of the repressor H-NS PLoS ONE, 15, e0240617.
Rivera-Mendoza,D. Martinez-Flores,I. Santamaria,R.I. Lozano,L. Bustamante,V.H. Perez-Morales,D.
2020. Genomic Analysis Reveals the Genetic Determinants Associated With Antibiotic Resistance in the Zoonotic Pathogen Campylobacter spp. Distributed Globally Frontiers in Microbiology, 11, 513070.
Banda,M.M. Manzo,R. Bustamante,V.H.
2019. HilD induces expression of a novel Salmonella Typhimurium invasion factor, YobH, through a regulatory cascade involving SprB Scientific Reports, 9, 12725.
Banda,M.M. Zavala-Alvarado,C. Perez-Morales,D. Bustamante,V.H.
2019. SlyA and HilD counteract H-NS-mediated repression on the ssrAB virulence operon of Salmonella Typhimurium and thus promote its activation by OmpR Journal of Bacteriology, 201, e00530-18.
Ilyas,B. Mulder,D.T. Little,D.J. Elhenawy,W. Banda,M.M. Perez-Morales,D. Tsai,C.N. Chau,N.Y.E. Bustamante,V.H. Coombes,B.K.
2018. Regulatory Evolution Drives Evasion of Host Inflammasomes by Salmonella Typhimurium Cell Reports, 25, 825-832.
Salgado,H. Martinez-Flores,I. Bustamante,V.H. Alquicira-Hernandez,K. Garcia-Sotelo,J.S. Garcia-Alonso,D. Collado-Vides,J.
2018. Using RegulonDB, the Escherichia coli K-12 Gene Regulatory Transcriptional Network Database Current Protocols in Bioinformatics, 61, 1-1.
Banda,M.M. Lopez,C. Manzo,R. Rico-Perez,G. Garcia,P. Rosales-Reyes,R. De la Cruz,M.A. Soncini,F.C. Garcia del Portillo,F. Bustamante,V.H.
2018. HilD and PhoP independently regulate the expression of grhD1, a novel gene required for Salmonella Typhimurium invasion of host cells Scientific Reports, 8, 4841-[correction 2018 artic no 7697].
Paredes-Amaya,C.C. Valdes-Garcia,G. Juarez-Gonzalez,V.R. Rudino-Pinera,E. Bustamante,V.H.
2018. The Hcp-like protein HilE inhibits homodimerization and DNA binding of the virulence-associated transcriptional regulator HilD in Salmonella Journal of Biological Chemistry, 293, 6578-6592.
Perez-Morales,D. Banda,M.M. Chau,N.Y.E. Salgado,H. Martinez-Flores,I. Ibarra,J.A. Ilyas,B. Coombes,B.K. Bustamante,V.H.
2017. The transcriptional regulator SsrB is involved in a molecular switch controlling virulence lifestyles of Salmonella PLoS Pathogens, 13, e1006497.
Martinez-Flores,I. Perez-Morales,D. Sanchez-Perez,M. Paredes,C.C. Collado-Vides,J. Salgado,H. Bustamante,V.H.
2016. In silico clustering of Salmonella global gene expression data reveals novel genes co-regulated with the SPI-1 virulence genes through HilD Scientific Reports, 6, 37858.
Wiesner,M. Calva,J.J. Bustamante,V.H. Perez-Morales,D. Fernandez-Mora,M. Calva,E. Silva,C.
2016. A multi-drug resistant Salmonella Typhimurium ST213 human-invasive strain (33676) containing the bla CMY-2 gene on an IncF plasmid is attenuated for virulence in BALB/c mice BMC Microbiology, 16, 18.
Perez-Morales,D. Bustamante,V.H.
2016. The global regulatory system Csr senses glucose through the phosphoenolpyruvate: carbohydrate phosphotransferase system Molecular Microbiology, 99, 623-626.
De la Cruz,M.A. Perez-Morales,D. Palacios,I.J. Fernandez-Mora,M. Calva,E. Bustamante,V.H.
2015. The two-component system CpxR/A represses the expression of Salmonella virulence genes by affecting the stability of the transcriptional regulator HilD Frontiers in Microbiology, 6, 807.
Gutierrez-Huante,M. Martinez,H. Bustamante,V.H. Puente,J.L. Sanchez,J.
2015. Bicarbonate enhances the in vitro antibiotic activity of kanamycin in Escherichia coli Letters in Applied Microbiology, 60, 440-446.
Ipinza,F. Collao,B. Monsalva,D. Bustamante,V.H. Luraschi,R. Alegria-Arcos,M. Almonacid,D.E. Aguayo,D. Calderon,I.L. Gil,F. Santiviago,C.A. Morales,E.H. Calva,E. Saavedra,C.P.
2014. Participation of the Salmonella OmpD Porin in the Infection of RAW264.7 Macrophages and BALB/c Mice PLoS ONE, 9, e111062.
Martinez,L.C. Banda,M.M. Fernandez-Mora,M. Santana,F.J. Bustamante,V.H.
2014. HilD Induces Expression of SPI-2 Genes by Displacing the Global Negative Regulator H-NS from ssrAB Journal of Bacteriology, 196, 3746-3755.
Bustamante,V.H. Calva,E.
2014. LeuO, a dormant sentinel for SPI-1? Molecular Microbiology, 91, 1054-1056.
Martinez,L.C. Martinez-Flores,I. Salgado,H. Fernandez-Mora,M. Medina-Rivera,A. Puente,J.L. Collado-Vides,J. Bustamante,V.H.
2014. In Silico Identification and Experimental Characterization of Regulatory Elements Controlling the Expression of the Salmonella csrB/C Genes Journal of Bacteriology, 196, 325-336.
Durand,D. Ochoa,T.J. Bellomo,S.M. Contreras,C.A. Bustamante,V.H. Ruiz,J. Cleary,T.G.
2013. Detection of Secretory Immunoglobulin A in Human Colostrum as Mucosal Immune Response against Proteins of the Type Three Secretion System of Salmonella, Shigella and Enteropathogenic Escherichia Coli Pediatric Infectious Disease Journal, 32, 1122-1126.
Garcia-Angulo,V.A. Martinez-Santos,V.I. Villasenor,T. Santana,F.J. Huerta-Saquero,A. Martinez,L.C. Jimenez,R. Lara-Ochoa,C. Tellez-Sosa,J. Bustamante,V.H. Puente,J.L.
2012. A Distinct Regulatory Sequence Is Essential for the Expression of a Subset of nle Genes in Attaching and Effacing Escherichia coli Journal of Bacteriology, 194, 5589-5603.
Bustamante,V.H. Villalba,M.I. Garcia-Angulo,V.A. Vazquez,A. Martinez,L.C. Jimenez,R. Puente,J.L.
2011. PerC and GrlA independently regulate Ler expression in enteropathogenic Escherichia coli Molecular Microbiology, 82, 398-415.
Martinez,L.C. Yakhnin,H. Camacho,M.I. Georgellis,D. Babitzke,P. Puente,J.L. Bustamante,V.H.
2011. Integration of a complex regulatory cascade involving the SirA/BarA and Csr global regulatory systems that controls expression of the Salmonella SPI-1 and SPI-2 virulence regulons through HilD Molecular Microbiology, 80, 1637-1656.
Jimenez,R. Cruz-Migoni,S.B. Huerta-Saquero,A. Bustamante,V.H. Puente,J.L.
2010. Molecular characterization of GrlA, a specific positive regulator of ler expression in enteropathogenic Escherichia coli Journal of Bacteriology, 192, 4627-4642.
Bustamante,V.H. Martinez,L.C. Santana,F.J. Knodler,L.A. Steele-Mortimer,O. Puente,J.L.
2008. HilD-mediated transcriptional cross-talk between SPI-1 and SPI-2 Proceedings of the National Academy of Sciences of the United States of America, 105, 14591-14596.
De la Cruz,M.A. Fernandez-Mora,M. Guadarrama,C. Flores-Valdez,M.A. Bustamante,V.H. Vazquez,A. Calva,E.
2007. LeuO antagonizes H-NS and StpA-dependent repression in Salmonella enterica ompS1 Molecular Microbiology, 66, 727-743.
Duong,N. Osborne,S. Bustamante,V.H. Tomljenovic,A.M. Puente,J.L. Coombes,B.K.
2007. Thermosensing coordinates a cis-regulatory module for transcriptional activation of the intracellular virulence system in salmonella enterica serovar typhimurium Journal of Biological Chemistry, 282, 34077-84.
Barba,J. Bustamante,V.H. Flores-Valdez,M.A. Deng,W. Finlay,B.B. Puente,J.L.
2005. A Positive Regulatory Loop Controls Expression of the Locus of Enterocyte Effacement-Encoded Regulators Ler and GrlA Journal of Bacteriology, 187, 7918-7930.
Li,Y.N. Bustamante,V.H. Lux,R. Zusman,D. Shi,W.
2005. Divergent Regulatory Pathways Control A and S Motility in Myxococcus xanthus through FrzE, a CheA-CheY Fusion Protein Journal of Bacteriology, 187, 1716-1723.
Bustamante,V.H. Martinez-Flores,I. Vlamakis,H.C. Zusman,D.R.
2004. Analysis of the Frz signal transduction system of Myxococcus xanthus shows the importance of the conserved C-terminal region of the cytoplasmic chemoreceptor FrzCD in sensing signals Molecular Microbiology, 53, 1501-1513.
Sanchez-SanMartin,C. Bustamante,V.H. Calva,E. Puente,J.L.
2001. Transcriptional regulation of the orf19 gene and the tir-cesT-eae operon of enteropathogenic Escherichia coli Journal of Bacteriology, 183, 2823-2833.
Bustamante,V.H. Santana,F.J. Calva,E. Puente,J.L.
2001. Transcriptional regulation of type III secretion genes in enteropathogenic Escherichia coli: Ler antagonizes H-NS-dependent repression Molecular Microbiology, 39, 664-678.
Martinez-Flores,I. Cano,R. Bustamante,V.H. Calva,E. Puente,J.L.
1999. The ompB operon partially determines differential expression of OmpC in Salmonella typhi and Escherichia coli Journal of Bacteriology, 181, 556-562.
Bustamante,V.H. Calva,E. Puente,J.L.
1998. Analysis of cis-acting elements required for bfpA expression in enteropathogenic Escherichia coli Journal of Bacteriology, 180, 3013-3016.
Tobe,T. Schoolnik,G.K. Sohel,I. Bustamante,V.H. Puente,J.L.
1996. Cloning and characterization of bfpTVW, genes required for the transcriptional activation of bfpA in enteropathogenic Escherichia coli Molecular Microbiology, 21, 963-975.
Bustamante,V.H. Puente,J.L. Sanchez-Lopez,F. Bobadilla,M. Calva,E.
1995. Identification of Campylobacter jejuni and C. coli using the rpoB gene and a cryptic DNA fragment from C. jejuni Gene, 165, 1-8.
Martinez-Flores,I. Bustamante,V.H. Puente,J.L. Calva,E.
1995. CLONING AND CHARACTERIZATION OF THE SALMONELLA-TYPHI OMPR AND ENVZ GENES.Asia-Pacific Journal Of Molecular Biology And Biotechnology, 3, 135-144.
Otras Publicaciones Ibarra-Garcia,J.A. Bustamante-Santillan,V.H.
2018. Desarmando a los patógenos: los compuestos antivirulencia como alternativa a los antbióticos Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 15, 18-21.
Estrada De LosSantos,P. Ibarra-Garcia,J.A. Bustamante-Santillan,V.H.
2018. Microbios contra microbios. La batalla microscópica que ha beneficiado a la humanidad Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 15, 23-25.
Cazares-Lopez,D. Bustamante-Santillan,V.H. Martinez-Flores,I.
2018. "El enemigo de mi enemigo es mi amigo": el uso de virus como estrategia antibacteriana Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 15, 30-32.
Perez-Morales,D. Bustamante-Santillan,V.H.
2018. Crisis mundial por bacterias patógenas resisitentes a antibióticos: si no hay acciones hoy, no habrá cura mañana Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 15, 3-5.
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