. Instituto de Biotecnologia UNAM

IBT-UNAM : Jose Luis De la Vega Beltran

Jose Luis De la Vega Beltran

Técnico Académico
Nivel I del SNI
Grupo del Dr. Alberto Darszon

email: vega @ibt.unam.mx
Teléfonos

Laboratorio +52 (777) 329-1611
desde la CDMX 562-27611
red UNAM 27611

Estudiantes

Hiram Pacheco "Estudio de la depolarización inducida por EGTA en espermatozoides de humano"

Publicaciones recientes

Zhao,R. Kennedy,K. de Blas,G.A. Orta,G. Pavarotti,M.A. Arias,R.J. de la Vega-Beltran,J.L. Li,Q. Dai,H. Perozo,E. Mayorga,L.S. Darszon,A. Goldstein,S.A.N. 2018. Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor Proceedings of the National Academy of Sciences of the United States of America, 115, E11847-E11856.

Orta,G. Vega-Beltran,J.L. Hidalgo,D. Santi,C.M. Visconti,P. Darszon,A. 2018. CatSper channels are regulated by protein kinase A Journal of Biological Chemistry, 293, 16830.

Stival,C. Ritagliati,C. Xu,X. Gervasi,M.G. Luque,G.M. Baro,G.C. Vega-Beltran,J.L. Torres,N.I. Darszon,A. Krapf,D. Buffone,M.G. Visconti,P. Krapf,D. 2018. Disruption of protein kinase A localization induces acrosomal exocytosis in capacitated mouse sperm Journal of Biological Chemistry, 293, 9435-9447.

Chavez,J.C. de la Vega-Beltran,J.L. Jose,O. Torres,P. Nishigaki,T. Trevino,C.L. Darszon,A. 2018. Acrosomal alkalization triggers Ca2+ release and acrosome reaction in mammalian spermatozoa Journal of Cellular Physiology, 233, 4735-4747.

Alvau,A. Battistone,M.A. Gervasi,M.G. Navarrete,F.A. Xu,X. Sanchez-Cardenas,C. de la Vega-Beltran,J.L. Da- Ros,V. Greer,P. Darszon,A. Krapf,D. Salicioni,A.M. Cuasnicu,P. Visconti,P.E. 2016. The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm Development, 143, 2325-2333.

Jose,O. Torres-Rodriguez,P. Forero-Quintero,L.S. Chavez,J.C. de la Vega-Beltran,J.L. Carta,F. Supuran,C.T. Deitmer,J.W. Trevino,C.L. 2015. Carbonic anhydrases and their functional differences in human and mouse sperm physiology Biochemical and Biophysical Research Communications, 468, 713-718.

Ernesto,J.I. Weigel-Munoz M. Battistone,M.A. Vasen,G. Martinez-Lopez,P. Orta,G. Figueiras-Fierro,D. de la Vega-Beltran,J.L. Moreno,I.A. Guidobaldi,H.A. Giojalas,L. Darszon,A. Cohen,D.J. Cuasnicu,P.S. 2015. CRISP1 as a novel CatSper regulator that modulates sperm motility and orientation during fertilization Journal of Cell Biology, 210, 1213-1224.

Wertheimer,E. Krapf,D. Vega-Beltran,J.L. Sanchez-Cardenas,C. Navarrete,F. Haddad,D. Escoffier,J. Salicioni,A.M. Levin,L.R. Buck,J. Mager,J. Darszon,A. Visconti,P.E. 2013. Compartmentalization of Distinct cAMP Signaling Pathways in Mammalian Sperm Journal of Biological Chemistry, 288, 35307-35320.

Balderas,E. Sanchez-Cardenas,C. Chavez,J.C. de la Vega-Beltran,J.L. Gomez-Lagunas,F. Trevino,C.L. Darszon,A. 2013. The anti-inflammatory drug celecoxib inhibits t-type Ca currents in spermatogenic cells yet it elicits the acrosome reaction in mature sperm FEBS Letters, 587, 2412-2419.

Chavez,J.C. de la Vega-Beltran,J.L. Escoffier,J. Visconti,P.E. Trevino,C.L. Darszon,A. Salkoff,L. Santi,C.M. 2013. Ion Permeabilities in Mouse Sperm Reveal an External Trigger for SLO3-Dependent Hyperpolarization PLoS ONE, 8, e60578.

de la Vega-Beltran,J.L. Sanchez-Cardenas,C. Krapf,D. Hernandez-Gonzalez,E.O. Wertheimer,E. Trevino,C.L. Visconti,P.E. Darszon,A. 2012. Mouse sperm membrane potential hyperpolarization is necessary and sufficient to prepare sperm for the acrosome reaction Journal of Biological Chemistry, 287, 44384-44393.

Visconti,P.E. Krapf,D. de la Vega-Beltran,J.L. Acevedo,J.J. Darszon,A. 2011. Ion channels, phosphorylation and mammalian sperm capacitation Asian Journal of Andrology, 13, 395-405.

Gibbs,G.M. Orta,G. Reddy,T. Koppers,A.J. Martinez-Lopez,P. de la Vega-Beltran,J.L. Lo,J.C. Veldhuis,N. Jamsai,D. McIntyre,P. Darszon,A. O'Bryan,M.K. 2011. Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function Proceedings of the National Academy of Sciences of the United States of America, 108, 7034-7039.

Martinez-Lopez,P. Trevino,C.L. de la Vega-Beltran,J.L. Blas,G.D. Monroy,E. Beltran,C. Orta,G. Gibbs,G.M. O'Bryan,M.K. Darszon,A. 2011. TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction Journal of Cellular Physiology, 226, 1620-1631.

Chavez,J.C. de Blas,G.A. de la Vega-Beltran,J.L. Nishigaki,T. Chirinos,M. Gonzalez-Gonzalez,M.E. Larrea,F. Solis,A. Darszon,A. Trevino,C.L. 2011. The opening of maitotoxin-sensitive calcium channels induces the acrosome reaction in human spermatozoa: differences from the zona pellucida Asian Journal of Andrology, 13, 159-165.

Santi,C.M. Martinez-Lopez,P. de la Vega-Beltran,J.L. Butler,A. Alisio,A. Darszon,A. Salkoff,L. 2010. The SLO3 sperm-specific potassium channel plays a vital role in male fertility FEBS Letters, 584, 1041-1046.

Hernandez-Gonzalez,E.O. Trevino,C.L. Castellano,L.E. de la Vega-Beltran,J.L. Ocampo,A.Y. Wertheimer,E. Visconti,P.E. Darszon,A. 2007. Involvement of cystic fibrosis transmembrane conductance regulator in mouse sperm capacitation Journal of Biological Chemistry, 282, 24397-24406.

Galindo,B.E. de la Vega-Beltran,J.L. Labarca,P. Vacquier,V.D. Darszon,A. 2007. Sp-tetraKCNG: A novel cyclic nucleotide gated K(+) channel Biochemical and Biophysical Research Communications, 354, 668-675.

Acevedo,J.J. Mendoza-Lujambio,I. de la Vega-Beltran,J.L. Trevino,C.L. Felix,R. Darszon,A. 2006. K(ATP) channels in mouse spermatogenic cells and sperm, and their role in capacitation Developmental Biology, 289, 395-405.

Trevino,C.L. de la Vega-Beltran,J.L. Nishigaki,T. Felix,R. Darszon,A. 2006. Maitotoxin potently promotes Ca(2+) influx in mouse spermatogenic cells and sperm, and induces the acrosome reaction Journal of Cellular Physiology, 206, 449-456.

Schulz,J.R. de la Vega-Beltran,J.L. Beltran,C. Vacquier,V.D. Darszon,A. 2004. Ion channel activity of membrane vesicles released from sea urchin sperm during the acrosome reaction Biochemical and Biophysical Research Communications, 321, 88-93.

Felix,R. Sandoval,A. Sanchez,D. Gomora,J.C. Vega-Beltran,J.L. Trevino,C.L. Darszon,A. 2003. ZD7288 inhibits low-threshold Ca(2+) channel activity and regulates sperm function Biochemical and Biophysical Research Communications, 311, 187-192.

Lopez-Gonzalez,I. Olamendi-Portugal,T. de la Vega-Beltran,J.L. van der Walt,J. Dyason,K. Possani,L.D. Felix,R. Darszon,A. 2003. Scorpion toxins that block T-type Ca(2+) channels in spermatogenic cells inhibit the sperm acrosome reaction Biochemical and Biophysical Research Communications, 300, 408-414.

Demarco,I.A. Espinosa,F. Edwards,J. Sosnik,J. de la Vega-Beltran,J.L. Hockensmith,J.W. Kopf,G.S. Darszon,A. Visconti,P.E. 2003. Involvement of a Na+/HCO3-cotransporter in mouse sperm capacitation Journal of Biological Chemistry, 278, 7001-7009.

Lopez-Gonzalez,I. de la Vega-Beltran,J.L. Santi,C.M. Florman,H.M. Felix,R. Darszon,A. 2001. Calmodulin antagonists inhibit t-type ca(2+) currents in mouse spermatogenic cells and the zona pellucida-induced sperm acrosome reaction Developmental Biology, 236, 210-219.

Munoz-Garay,C. de la Vega-Beltran,J.L. Delgado,R. Labarca,P. Felix,R. Darszon,A. 2001. Inwardly rectifying k(+) channels in spermatogenic cells: functional expression and implication in sperm capacitation Developmental Biology, 234, 261-274.

Espinosa,F. Lopez-Gonzalez,I. Munoz-Garay,C. Felix,R. de la Vega-Beltran,J.L. Kopf,G.S. Visconti,P.E. Darszon,A. 2000. Dual regulation of the T-type Ca(2+) current by serum albumin and beta-estradiol in mammalian spermatogenic cells FEBS Letters, 475, 251-256.

Espinosa,F. Lopez-Gonzalez,I. Serrano,C.J. Gasque,G. de la Vega-Beltran,J.L. Trevino,C.L. Darszon,A. 1999. 3.0.CO;2-B> Anion channel blockers differentially affect T-type Ca(2+) currents of mouse spermatogenic cells, alpha1E currents expressed in Xenopus oocytes and the sperm acrosome reaction Developmental Genetics, 25, 103-114.

Darszon,A. Espinoza,F. Santi,C. Lievano,A. Lopez,I. de la Vega-Beltran,J.L. Delgado,R. Labarca,P. Hernandez,A. 1998. Ca 2+ and Cl.Zygote, 6, S22-S23.

Espinosa,F. de la Vega-Beltran,J.L. Lopez-Gonzalez,I. Delgado,R. Labarca,P. Darszon,A. 1998. Mouse sperm patch-clamp recordings reveal single Cl- channels sensitive to niflumic acid, a blocker of the sperm acrosome reaction FEBS Letters, 426, 47-51.

Trevino,C.L. Orta,G. Figueiras-Fierro,D. De la Vega-Beltran JL Ferreira,G. Balderas,E. Jose,O. Darszon,A. 2014. Cl- channels and transporters in sperm physiology en: Iwano,M. Sexual Reproduction in Animals and Plants. Tokyo. Springer-Japan. pags. 59-84

Otras Publicaciones

Luque,G.M. Romarowski,A. Gervasi,M.G. Orta,G. de la Vega-Beltran,J. Stival,C. Gilio,N. Dalotto-Moreno,T. Krapf,D. Visconti,P.E. Krapf,D. Darszon,A. Buffone,M.G. 2020. Cdc42 activity is essential for the interplay between cAMP/PKA pathway and CatSper function bioRxiv, Preprint posted August 25, 2020, .