IBT-UNAM : Dra. Lidia Riano Umbarila
Dra. Lidia Riano Umbarila
Responsable Técnico del Proyecto: Dr. Baltazar Becerril
email: umbarila @ibt.unam.mx
Teléfonos
Oficina +52 (777) 311-4900 ext 247 Laboratorio +52 (777) 329-1669 red UNAM 27669 +52 (777) 311-4900 ext 247
Estudiantes Irving Utrera
Lic. Mauricio Perez
Vianey Margarita Rojas
M.C. Jose Alberto Romero
Publicaciones recientes
Lopez-Giraldo,A.E. Olamendi-Portugal,T. Riano-Umbarila,L. Becerril,B. Possani,L.D. Delepierre,M. Rio-Portilla,F.D.
2020. The three-dimensional structure of the toxic peptide Cl13 from the scorpion Centruroides limpidus Toxicon, 184, 158-166.
Gomez-Ramirez,I.V. Riano-Umbarila,L. Olamendi-Portugal,T. Restano-Cassulini,R. Possani,L.D. Becerril,B.
2020. Biochemical, electrophysiological and immunological characterization of the venom from Centruroides baergi, a new scorpion species of medical importance in Mexico Toxicon, 184, 10-18.
Riano-Umbarila,L. Rojas-Trejo,V.M. Romero-Moreno,J.A. Costas,M. Utrera-Espindola,I. Olamendi-Portugal,T. Possani,L.D. Becerril,B.
2020. Comparative assessment of the VH-VL and VL-VH orientations of single-chain variable fragments of scorpion toxin-neutralizing antibodies Molecular Immunology, 122, 141-147.
Riano-Umbarila,L. Gomez-Ramirez,I.V. Ledezma-Candanoza,L.M. Olamendi-Portugal,T. Rodriguez-Rodriguez,E.R. Fernandez-Taboada,G. Possani,L.D. Becerril,B.
2019. Generation of a Broadly Cross-Neutralizing Antibody Fragment against Several Mexican Scorpion Venoms Toxins (Basel), 11, 32.
Riano-Umbarila,L. Rodriguez-Rodriguez,E.R. Santibanez-Lopez,C.E. Guereca,L. Uribe-Romero,S.J. Gomez-Ramirez,I.V. Carcamo-Noriega,E.N. Possani,L.D. Becerril,B.
2017. Updating knowledge on new medically important scorpion species in Mexico Toxicon, 138, 130-137.
Olamendi-Portugal,T. Restano-Cassulini,R. Riano-Umbarila,L. Becerril,B. Possani,L.D.
2017. Functional and immuno-reactive characterization of a previously undescribed peptide from the venom of the scorpion centruroides limpidus Peptides, 87, 34-40.
Rodriguez-Rodriguez,E.R. Olamendi-Portugal,T. Serrano-Posada,H. Arredondo-Lopez,J.N. Gomez-Ramirez,I. Fernandez-Taboada,G. Possani,L.D. Vega,G.A. Riano-Umbarila,L. Becerril,B.
2016. Broadening the neutralizing capacity of a family of antibody fragments against different toxins from Mexican scorpions Toxicon, 119, 52-63.
Riano-Umbarila,L. Ledezma-Candanoza,L.M. Serrano-Posada,H. Fernandez-Taboada,G. Olamendi-Portugal,T. Rojas-Trejo,S. Gomez-Ramirez,I.V. Rudino-Pinera,E. Possani,L.D. Becerril,B.
2016. Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin Journal of Biological Chemistry, 291, 1619-1630.
Riano-Umbarila,L. Olamendi-Portugal,T. Morelos-Juarez,C. Gurrola,G.B. Possani,L.D. Becerril,B.
2013. A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins Toxicon, 76, 370-376.
Rodriguez-Rodriguez,E.R. Ledezma-Candanoza,L.M. Contreras-Ferrat,L.G. Olamendi-Portugal,T. Possani,L.D. Becerril,B. Riano-Umbarila,L.
2012. A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody Journal of Molecular Biology, 423, 337-350.
Amaro,I. Riano-Umbarila,L. Becerril,B. Possani,L.D.
2011. Isolation and characterization of a human antibody fragment specific for Ts1 toxin from Tityus serrulatus scorpion Immunology Letters, 139, 73-79.
Canul-Tec,J.C. Riano-Umbarila,L. Rudino-Pinera,E. Becerril,B. Possani,L.D. Torres-Larios,A.
2011. Structural basis of neutralization of the major toxic component from the scorpion centruroides noxius hoffmann by a human-derived single chain antibody fragment Journal of Biological Chemistry, 286, 20892-20900.
Riano-Umbarila,L. Contreras-Ferrat,G. Olamendi-Portugal,T. Morelos-Juarez,C. Corzo,G. Possani,L.D. Becerril,B.
2011. Exploiting cross-reactivity to neutralize two different scorpion venoms with one single-chain antibody fragment Journal of Biological Chemistry, 286, 6143-6151.
Espino-Solis,G.P. Riano-Umbarila,L. Becerril,B. Possani,L.D.
2009. Antidotes against venomous animals: State of the art and prospectives Journal of Proteomics, 72, 183-199.
Pedraza-Escalona,M. Becerril-Lujan,B. Agundis,C. Dominguez-Ramirez,L. Pereyra,A. Riano-Umbarila,L. Rodriguez-Romero,A.
2009. Analysis of B-cell epitopes from the allergen Hev b 6.02 revealed by using blocking antibodies Molecular Immunology, 46, 668-676.
Riano-Umbarila,L. Juarez-Gonzalez,V.R. Olamendi-Portugal,T. Ortiz-Leon,M. Possani,L.D. Becerril,B.
2005. A strategy for the generation of specific human antibodies by directed evolution and phage display Febs Journal, 272, 2591-2601.
Juarez-Gonzalez,V.R. Riano-Umbarila,L. Quintero-Hernandez,V. Olamendi-Portugal,T. Ortiz-Leon,M. Ortiz,E. Possani,L.D. Becerril,B.
2005. Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2 Journal of Molecular Biology, 346, 1287-1297.
Otras Publicaciones Becerril-Lujan,B. Riano,L. Possani,L.
2014. Bancos de anticuerpos recombinantes de origen humano: una fuente ideal de antivenenos modernos contra la picadura de alacrán Revista Digital Universitaria, 15, art 84.
Becerril-Lujan,B. Riano-Umbarila,L.
2008. Quinta Generación de anti-venenos contra la picadura de alacrán Hypatia, 25, .
Patentes L. Riaño U., B. Becerril L. y L. Possani P 2009 Variantes de anticuerpos humanos que reconocen específicamente a la toxina CN2 y al veneno del alacrán Centruroides noxius .UNAM México.
L. Riaño, B. Becerril y L.D. Possani 2008 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpion venom.UNAM Estados Unidos.
Riaño L. , B. Becerril y L.D. Possani 2005 Human antibody variants that specifically recognize the toxin CN2 from Centruroides noxius scorpionon venom.
Catedrático Conacyt