. Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Tomas David Lopez Diaz

Dr. Tomas David Lopez Diaz

Investigador
Tutor de Maestría y Doctorado
Nivel I del SNI
Grupo del Dr. Carlos Federico Arias

email: tdlopez @ibt.unam.mx
Teléfonos
Oficina +52 (777) 311-4900 ext 239

Laboratorio +52 (777) 329-1612
desde la CDMX 562-27612
red UNAM 27612
+52 (777) 311-4900 ext 239

- Licenciatura: Biología, Escuela de Biología, Universidad Autonoma de Puebla (1993)
- Maestría: en Ciencias, especialidad en Genetica y Biología Molecular, CINVESTAV-IPN, Depto. de Genetica y Biología Molecular (1995)
- Doctorado: en Ciencias, especialidad en Genetica y Biología Molecular, CINVESTAV-IPN, Depto. de Genetica y Biología Molecular (1997)
- Premio Arturo Rosemblueth a la mejor tesis doctoral en el area de Ciencias Biologicas del CINVESTAV-IPN (1997)
- Premio Weizmann a la mejor tesis doctoral en el area de Ciencias Naturales, Academia Mexicana de Ciencias (1999)
- Estancia de investigacion en el CINVESTAV-IPN, Depto. de Genetica y Biología Molecular (abril 1998-marzo 1999)

Estudiantes

M.V.Z. Luis Eduardo Jimenez

Diana Berenice Ramirez

Publicaciones recientes

Shrivastava,G. Visoso-Carvajal,G. Garcia-Cordero,J. Leon-Juarez,M. Chavez-Munguia,B. Lopez,T. Nava,P. Villegas-Sepulveda,N. Cedillo-Barron,L. 2020. Dengue Virus Serotype 2 and Its Non-Structural Proteins 2A and 2B Activate NLRP3 Inflammasome Frontiers in Immunology, 11, 352.

Meneses-Romero,E. Hernandez-Orihuela,L. Pando-Robles,V. Lopez,T.D. Oses-Prieto,J.A. Burlingame,A.L. Batista,C.V.F. 2020. Quantitative proteomic analysis reveals high interference on protein expression of H9c2 cells activated with glucose and cardiotonic steroids Journal of Proteomics, 211, 103536.

Meyer,L. Lopez,T. Espinosa,R. Arias,C.F. Vollmers,C. DuBois,R.M. 2019. A simplified workflow for monoclonal antibody sequencing PLoS ONE, 14, e0218717.

Espinosa,R. Lopez,T. Bogdanoff,W.A. Espinoza,M.A. Lopez,S. DuBois,R.M. Arias,C.F. 2019. Isolation of neutralizing monoclonal antibodies to human astrovirus and characterization of virus variants that escape neutralization Journal of Virology, 93, e01465-18.

Diaz-Salinas,M.A. Casorla,L.A. Lopez,T. Lopez,S. Arias,C.F. 2018. Most rotavirus strains require the cation-independent mannose-6-phosphate receptor, sortilin-1, and cathepsins to enter cells Virus Research, 245, 44-51.

Casorla-Perez,L.A. Lopez,T. Lopez,S. Arias,C.F. 2018. The ubiquitin-proteasome system is necessary for the efficient replication of human astrovirus Journal of Virology, 92, e01809-e01817.

Bogdanoff,W.A. Perez,E.I. Lopez,T. Arias,C.F. DuBois,R.M. 2018. Structural basis for the escape of human astrovirus from antibody neutralization: broad implications for rational vaccine design Journal of Virology, 92, e01546-17.

Lecona-Valera,A.N. Tao,D. Rodriguez,M.H. Lopez,T. Dinglasan,R.R. Rodriguez,M.C. 2016. An antibody against an Anopheles albimanus midgut myosin reduces Plasmodium berghei oocyst development Parasites and Vectors, 9, 274.

Lopez,T. Lopez,S. Arias,C.F. 2015. The tyrosine kinase inhibitor genistein induces the detachment of rotavirus particles from the cell surface Virus Research, 210, 141-148.

Silva-Ayala,D. Lopez,T. Gutierrez,M. Perrimon,N. Lopez,S. Arias,C.F. 2013. Genome-wide RNAi screen reveals a role for the ESCRT complex in rotavirus cell entry Proceedings of the National Academy of Sciences of the United States of America, 110, 10270-10275.

Lopez,T. Silva-Ayala,D. Lopez,S. Arias,C.F. 2012. Methods suitable for high-throughput screening of siRNAs and other chemical compounds with the potential to inhibit rotavirus replication Journal of Virological Methods, 179, 242-249.

Lopez,T. Silva-Ayala,D. Lopez,S. Arias,C.F. 2011. Replication of the rotavirus genome requires an active ubiquitin-proteasome system Journal of Virology, 85, 11964-11971.

Lopez,T. Lopez,S. Arias,C.F. 2006. Heat shock enhances the susceptibility of BHK cells to rotavirus infection through the facilitation of entry and post-entry virus replication steps Virus Research, 121, 74-83.

Lopez,T. Rojas,M. Ayala-Breton,C. Lopez,S. Arias,C.F. 2005. Reduced expression of the rotavirus NSP5 gene has a pleiotropic effect on virus replication Journal of General Virology, 86, 1609-1617.

Lopez,T. Camacho,M. Zayas,M. Najera,R. Sanchez,R. Arias,C.F. Lopez,S. 2005. Silencing the morphogenesis of rotavirus Journal of Virology, 79, 184-192.

Arias,C.F. Dector,M.A. Segovia,L. Lopez,T. Camacho,M. Isa,P. Espinosa,R. Lopez,S. 2004. RNA silencing of rotavirus gene expression Virus Research, 102, 43-51.

Sanchez-SanMartin,C. Lopez,T. Arias,C.F. Lopez,S. 2004. Characterization of rotavirus cell entry Journal of Virology, 78, 2310-2318.

Gonzalez-Jasso,E. Lopez,T. Lucas,D. Berthou,F. Manno,M. Ortega,A. Albores,A. 2003. CYP2E1 regulation by benzene and other small organic chemicals in rat liver and peripheral lymphocytes Toxicology Letters, 144, 55-67 * .

Zapata-Perez,O. Gold-Bouchot,G. Ortega,A. Lopez,T. Albores,A. 2002. Effect of pyrene on hepatic cytochrome P450 1A (CYP1A) expression in Nile Tilapia (Oreochromis niloticus) Archives of Environmental Contamination and Toxicology, 42, 477-485.

Arias,C.F. Isa,P. Guerrero,C. Mendez,E. Zarate,S. Lopez,T. Espinosa,R. Romero,P. Lopez,S. 2002. Molecular biology of rotavirus cell entry Archives of Medical Research, 33, 356-361.

Guerrero,C.A. Bouyssounade,D. Zarate,S. Isa,P. Lopez,T. Espinosa,R. Romero,P. Mendez,E. Lopez,S. Arias,C.F. 2002. Heat shock cognate protein 70 is involved in rotavirus cell entry Journal of Virology, 76, 4096-4102.

Aguirre,A. Lopez,T. Lopez-Bayghen,E. Ortega,A. 2000. Glutamate regulates kainate-binding protein expression in cultured chick Bergmann glia through an activator protein-1 binding site Journal of Biological Chemistry, 275, 39246-39253 * .

Lopez,T. Lopez-Colome,A.M. Ortega,A. 1998. Changes in GluR4 expression induced by metabotropic receptor activation in radial glia cultures Molecular Brain Research, 58, 40-46 * .

Lopez,T. Lopez-Colome,A.M. Ortega,A. 1997. NMDA receptors in cultured radial glia FEBS Letters, 405, 245-248 * .

Lopez,T. Lopez-Colome,A.M. Ortega,A. 1994. AMPA/KA receptor expression in radial glia Neuroreport, 5, 504-506 * .

Libros y capítulos recientes

Arias,C.F. Lopez,T. 2017. Chapter 51 Astroviruses en: Hayden,F.G. Clinical Virology 4a ed. Washington. American Society for Microbiology. pags. 1231-1242

Arias,C.F. Lopez,T. Murillo,A. 2016. Chapter 4.2 Astrovirus replication and reverse genetics en: Gre,H.B. Viral Gastroenteritis: Molecular biology, pathogenesis, epidemiology and vaccine development. Elsevier Academic Press. pags. 483-495

Lopez,T. Silva,D. Lopez,S. Arias,C.F. 2008. RNA de interferencia: el silencio de los genes en: *agustin Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 10. Mexico, D.F.. UNAM. pags. 109-118

* Indica publicación con otra institución de adscripción