. Instituto de Biotecnologia UNAM

IBT-UNAM : Dr. Francisco Xavier Soberon Mainero

Dr. Francisco Xavier Soberon Mainero

Líder Académico »» Grupo
Investigador
Tutor de Maestría y Doctorado
Nivel III del SNI
Departamento de Ingeniería Celular y Biocatálisis

Líneas de investigación

email: soberon @ibt.unam.mx
Teléfonos
Oficina +52 (777) 329-1665
desde la CDMX 562-27665
red UNAM 27665

- Licenciatura: Química, Universidad Iberoamericana (1978)
- Maestría: en Investigacion Biomedica Basica, Instituto de Investigaciones Biomedicas-UNAM (1981)
- Doctorado: en Investigacion Biomedica Basica, Instituto de Investigaciones Biomedicas-CEINGEBI-UNAM (1984)
- Mencion honorífica en examen de Licenciatura (1978)
- Mencion honorífica en examen de Maestría (1981)
- Mencion honorífica en examen de Doctorado (1984)
- Medalla "Gabino Barreda"-UNAM por estudios de Maestría (1983)
- Beca del Programa de Superacion del Personal Academico de la UNAM (1979)

Premio Nacional de Química "Andrés Manuel del Río" Sociedad Química de México (1999)

Estudiantes

Ing. Omar Fernando Cruz

M.C. Brenda Georgina Uribe

David Galeana

Luis Moises Ledezma

Publicaciones recientes

Gonzalez-Covarrubias,V. Lozano,K. Texis,T. Guzman-Cruz,C.K. Rodriguez-Dorantes,M. Rubio-Carrasco,K. Mendez-Lorenzo,L.H. Soberon,X. 2020. Pharmacogenomics: Current Actionable Variants Revista de Investigacion Clinica, 73, * .

Cabrera-Contreras,R. Santamaria,R.I. Bustos,P. Martinez-Flores,I. Melendez-Herrada,E. Morelos-Ramirez,R. Barbosa-Amezcua,M. Gonzalez-Covarrubias,V. Silva-Herzog,E. Soberon,X. Gonzalez,V. 2019. Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in Mexico City in an eight-years survey PeerJ, 7, e8068 * .

Gonzalez-Covarrubias,V. Morales-Franco,M. Cruz-Correa,O.F. Martinez-Hernandez,A. Garcia-Ortiz,H. Barajas-Olmos,F. Genis-Mendoza,A.D. Martinez-Magana,J.J. Nicolini,H. Orozco,L. Soberon,X. 2019. Variation in Actionable Pharmacogenetic Markers in Natives and Mestizos From Mexico Frontiers in Pharmacology, 10, 1169 * .

Martinez-Magana,J.J. Genis-Mendoza,A.D. Gonzalez-Covarrubias,V. Jimenez-Guenchi,J. Galindo-Chavez,A.G. Roche-Bergua,A. Castaneda-Gonzalez,C. Lanzagorta,N. Soberon,X. Nicolini,H. 2019. Exploratory analysis of rare and novel variants in Mexican patients diagnosed with schizophrenia and dementia Revista de Investigacion Clinica, 71, 246-254 * .

Madrazo-Moya,C.F. Cancino-Munoz,I. Cuevas-Cordoba,B. Gonzalez-Covarrubias,V. Barbosa-Amezcua,M. Soberon,X. Muniz-Salazar,R. Martinez-Guarneros,A. Backer,C. Zarrabal-Meza,J. Sampieri-Ramirez,C. Enciso-Moreno,A. Lauzardo,M. Comas,I. Zenteno-Cuevas,R. 2019. Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico PLoS ONE, 14, e0213046 * .

Flannick,J. Mercader,J.M. Fuchsberger,C. Udler,M.S. Mahajan,A. Wessel,J. Teslovich,T.M. Caulkins,L. Koesterer,R. Barajas-Olmos,F. Blackwell,T.W. Boerwinkle,E. Brody,J.A. Centeno-Cruz,F. Chen,L. Chen,S. Contreras-Cubas,C. Cordova,E. Correa,A. Cortes,M. Defronzo,R.A. Dolan,L. Drews,K.L. Elliott,A. Floyd,J.S. Gabriel,S. Garay-Sevilla,M.E. Garcia-Ortiz,H. Gross,M. Han,S. Heard-Costa,N.L. Jackson,A.U. Jorgensen,M.E. Kang,H.M. Kelsey,M. Kim,B.J. Koistinen,H.A. Kuusisto,J. Leader,J.B. Linneberg,A. Liu,C.T. Liu,J. Lyssenko,V. Manning,A.K. Marcketta,A. Malacara-Hernandez,J.M. Martinez-Hernandez,A. Matsuo,K. Mayer-Davis,E. Mendoza-Caamal,E. Mohlke,K.L. Morrison,A.C. Ndungu,A. Ng,M.C.Y. O'Dushlaine,C. Payne,A.J. Pihoker,C. Post,W.S. Preuss,M. Psaty,B.M. Vasan,R.S. Rayner,N.W. Reiner,A.P. Revilla-Monsalve,C. Robertson,N.R. Santoro,N. Schurmann,C. So,W.Y. Soberon,X. Stringham,H.M. Strom,T.M. Tam,C.H.T. Thameem,F. Tomlinson,B. Torres,J.M. Tracy,R.P. van Dam,R.M. Vujkovic,M. Wang,S. Welch,R.P. Witte,D.R. Wong,T.Y. Atzmon,G. Barzilai,N. Blangero,J. Bonnycastle,L.L. Bowden,D.W. Chambers,J.C. Chan,E. Cheng,C.Y. Cho,Y.S. Collins,F.S. de Vries,P.S. Duggirala,R. Glaser,B. Gonzalez,C. Gonzalez,M.E. Groop,L. Kooner,J.S. Kwak,S.H. Laakso,M. Lehman,D.M. Nilsson,P. Spector,T.D. Tai,E.S. Tuomi,T. Tuomilehto,J. Wilson,J.G. Aguilar-Salinas,C.A. Bottinger,E. Burke,B. Carey,D.J. Chan,J.C.N. Dupuis,J. Frossard,P. Heckbert,S.R. Hwang,M.Y. Kim,Y.J. Kirchner,H.L. Lee,J.Y. Lee,J. Loos,R.J.F. Ma,R.C.W. Morris,A.D. O'Donnell,C.J. Palmer,C.N.A. Pankow,J. Park,K.S. Rasheed,A. Saleheen,D. Sim,X. Small,K.S. Teo,Y.Y. Haiman,C. Hanis,C.L. Henderson,B.E. Orozco,L. Tusie-Luna,T. Dewey,F.E. Baras,A. Gieger,C. Meitinger,T. Strauch,K. Lange,L. Grarup,N. Hansen,T. Pedersen,O. Zeitler,P. Dabelea,D. Abecasis,G. Bell,G.I. Cox,N.J. Seielstad,M. Sladek,R. Meigs,J.B. Rich,S.S. Rotter,J.I. Altshuler,D. Burtt,N.P. Scott,L.J. Morris,A.P. Florez,J.C. McCarthy,M.I. Boehnke,M. 2019. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls Nature, 570, 71-76 * .

Cornejo-Granados,F. Calderon de la Barca AM Torres,N. Martinez-Romero,E. Torres,J. Lopez-Vidal,Y. Soberon,X. Partida-Martinez,L.P. Pinto-Cardoso,S. Alcaraz,L.D. Pardo-Lopez,L. Canizales-Quinteros,S. Puente,J.L. Ochoa-Leyva,A. 2019. Microbiome-MX 2018: Microbiota and Microbiome opportunities in Mexico, a megadiverse country Research in Microbiology, 170, 235-241.

Flores-Bautista,J. Navarrete-Perea,J. Fragoso,G. Flisser,A. Soberon,X. Laclette,J.P. 2018. Fate of uptaken host proteins in Taenia solium and Taenia crassiceps cysticerci Bioscience Reports, 38, BSR20180636; * .

Ayon-Nunez,D.A. Fragoso,G. Espitia,C. Garcia-Varela,M. Soberon,X. Rosas,G. Laclette,J.P. Bobes,R.J. 2018. Identification and characterization of Taenia solium enolase as a plasminogen-binding protein Acta Tropica, 182, 69-79 * .

Gonzalez-Covarrubias,V. Urena-Carrion,J. Villegas-Torres,B. Cossio-Aranda,J.E. Trevethan-Cravioto,S. Izaguirre-Avila,R. Fiscal-Lopez,O.J. Soberon,X. 2017. Pharmacogenetic Variation in Over 100 Genes in Patients Receiving Acenocumarol Frontiers in Pharmacology, 8, 863 * .

Bikel,S. Jacobo-Albavera,L. Sanchez-Munoz,F. Cornejo-Granados,F. Canizales-Quinteros,S. Soberon,X. Sotelo-Mundo,R.R. Del Rio-Navarro,B.E. Mendoza-Vargas,A. Sanchez,F. Ochoa-Leyva,A. 2017. A novel approach for human whole transcriptome analysis based on absolute gene expression of microarray data PeerJ., 5, e4133.

Romero-Hidalgo,S. Ochoa-Leyva,A. Garciarrubio,A. Acuna-Alonzo,V. Antunez-Arguelles,E. Balcazar-Quintero,M. Barquera-Lozano,R. Carnevale,A. Cornejo-Granados,F. Fernandez-Lopez,J.C. Garcia-Herrera,R. Garcia-Ortiz,H. Granados-Silvestre,A. Granados,J. Guerrero-Romero,F. Hernandez-Lemus,E. Leon-Mimila,P. Macin-Perez,G. Martinez-Hernandez,A. Menjivar,M. Morett,E. Orozco,L. Ortiz-Lopez,G. Perez-Villatoro,F. Rivera-Morales,J. Riveros-McKay,F. Villalobos-Comparan,M. Villamil-Ramirez,H. Villarreal-Molina,T. Canizales-Quinteros,S. Soberon,X. 2017. Demographic history and biologically relevant genetic variation of Native Mexicans inferred from whole-genome sequencing Nature Communications, 8, 1005.

Navarrete-Perea,J. Isasa,M. Paulo,J.A. Corral-Corral,R. Flores-Bautista,J. Hernandez-Tellez,B. Bobes,R.J. Fragoso,G. Sciutto,E. Soberon,X. Gygi,S.P. Laclette,J.P. 2017. Quantitative multiplexed proteomics of Taenia solium cysts obtained from the skeletal muscle and central nervous system of pigs PLoS Neglected Tropical Diseases, 11, e0005962.

Bobes,R.J. Navarrete-Perea,J. Ochoa-Leyva,A. Anaya,V.H. Hernandez,M. Cervantes-Torres,J. Estrada,K. Sanchez-Lopez,F. Soberon,X. Rosas,G. Maroni-Nunes C. Garcia-Varela,M. Sotelo-Mundo,R.R. Lopez-Zavala,A.A. Gevorkian,G. Acero,G. Laclette,J.P. Fragoso,G. Sciutto,E. 2017. Experimental and theoretical approaches to investigate the immunogenicity of Taenia solium-derived KE7 antigen Infection and Immunity, 85, e00395-17.

Mercader,J.M. Liao,R.G. Davis,A. Dymek,Z. Estrada,K. Tukiainen,T. Huerta-Chagoya,A. Moreno-Macias,H. Jablonski,K.A. Hanson,R.L. Walford,G.A. Moran,I. Chen,L. Agarwala,V. Ordonez-Sanchez,M.L. Rodriguez-Guillen,R. Rodriguez-Torres,M. Segura-Kato,Y. Garcia-Ortiz,H. Centeno-Cruz,F. Barajas-Olmos,F. Caulkins,L. Puppala,S. Fontanillas,P. Williams,A. Bonas-Guarch,S. Hartl,C. Ripke,S. Tooley,K. Lane,J. Zerrweck,C. Martinez-Hernandez,A. Cordova,E.J. Mendoza-Caamal,E. Contreras-Cubas,C. Gonzalez-Villalpando,M.E. Cruz-Bautista,I. Munoz-Hernandez,L. Gomez-Velasco,D. Alvirde,U. Henderson,B.E. Wilkens,L.R. Le,M.L. Arellano-Campos,O. Riba,L. Harden,M. Platform,B.G. Gabriel,S. Abboud,H.E. Cortes,M.L. Revilla-Monsalve,C. Islas-Andrade,S. Soberon,X. Curran,J.E. Jenkinson,C.P. Defronzo,R.A. Lehman,D.M. Hanis,C.L. Bell,G.I. Boehnke,M. Blangero,J. Duggirala,R. Saxena,R. MacArthur,D. Ferrer,J. McCarroll,S.A. Torrents,D. Knowler,W.C. Baier,L.J. Burtt,N. Gonzalez-Villalpando,C. Haiman,C.A. Aguilar-Salinas,C.A. Tusie-Luna,T. Flannick,J. Jacobs,S.B.R. Orozco,L. Altshuler,D. Florez,J.C. 2017. A Loss-Of-Function Splice Acceptor Variant in IGF2 is Protective for Type 2 Diabetes Diabetes, 66, 2903-2914 * .

Cruz-Correa,O.F. Leon-Cachon,R.B. Barrera-Saldana,H.A. Soberon,X. 2017. Prediction of atorvastatin plasmatic concentrations in healthy volunteers using integrated pharmacogenetics sequencing Pharmacogenomics, 18, 121-131.

Navarrete-Perea,J. Moguel,B.A. Bobes,R.J. Villalobos,N. Carrero,J.C. Sciutto,E. Soberon,X. Laclette,J.P. 2017. Protein profiles of Taenia solium cysts obtained from skeletal muscles and the central nervous system of pigs: Search for tissue-specific proteins Experimental Parasitology, 172, 23-29.

Gonzalez-Covarrubias,V. Martinez-Magana,J.J. Coronado-Sosa,R. Villegas-Torres,B. Genis-Mendoza,A.D. Canales-Herrerias,P. Nicolini,H. Soberon,X. 2016. Exploring Variation in Known Pharmacogenetic Variants and its Association with Drug Response in Different Mexican Populations Pharmaceutical Research, 33, 2644-2652 * .

Navarrete-Perea,J. Toledano-Magana,Y. Torre,P. Sciutto,E. Bobes,R.J. Soberon,X. Laclette,J.P. 2016. Role of porcine serum haptoglobin in the host-parasite relationship of Taenia solium cysticercosis Molecular and Biochemical Parasitology, 207, 61-67.

Bikel,S. Valdez-Lara,A. Cornejo-Granados,F. Rico,K. Canizales-Quinteros,S. Soberon,X. Del Pozo-Yauner,L. Ochoa-Leyva,A. 2015. Combining metagenomics, metatranscriptomics and viromics to explore novel microbial interactions: towards a systems-level understanding of human microbiome Computational and Structural Biotechnology Journal, 13, 390-401.

Gomez,S. Adalid-Peralta,L. Palafox-Fonseca,H. Cantu-Robles,V.A. Soberon,X. Sciutto,E. Fragoso,G. Bobes,R.J. Laclette,J.P. Yauner,L.D. Ochoa-Leyva,A. 2015. Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR) Scientific Reports, 5, 9683 [erratum en vol 5 (12385) ].

Villegas-Torres,B. Sanchez-Giron,F. Jaramillo-Villafuerte,K. Soberon,X. Gonzalez-Covarrubias,V. 2015. Genotype frequencies of VKORC1 and CYP2C9 in Native and Mestizo populations from Mexico, potential impact for coumarin dosing Gene, 558, 235-240 * .

Moreno-Estrada,A. Gignoux,C.R. Fernandez-Lopez,J.C. Zakharia,F. Sikora,M. Contreras,A.V. Acuna-Alonzo,V. Sandoval,K. Eng,C. Romero-Hidalgo,S. Ortiz-Tello,P. Robles,V. Kenny,E.E. Nuno-Arana,I. Barquera-Lozano,R. Macin-Perez,G. Granados-Arriola,J. Huntsman,S. Galanter,J.M. Via,M. Ford,J.G. Chapela,R. Rodriguez-Cintron,W. Rodriguez-Santana,J.R. Romieu,I. Sienra-Monge,J.J. del Rio-Navarro,B. London,S.J. Ruiz-Linares,A. Garcia-Herrera,R. Estrada,K. Hidalgo-Miranda,A. Jimenez-Sanchez,G. Carnevale,A. Soberon,X. Canizales-Quinteros,S. Rangel-Villalobos,H. Silva-Zolezzi,I. Burchard,E.G. Bustamante,C.D. 2014. The genetics of Mexico recapitulates Native American substructure and affects biomedical traits Science, 344, 1280-1285 * .

Estrada,K. Aukrust,I. Bjorkhaug,L. Burtt,N.P. Mercader,J.M. Garcia-Ortiz,H. Huerta-Chagoya,A. Moreno-Macias,H. Walford,G. Flannick,J. Williams,A.L. Gomez-Vazquez,M.J. Fernandez-Lopez,J.C. Martinez-Hernandez,A. Centeno-Cruz,F. Mendoza-Caamal,E. Revilla-Monsalve,C. Islas-Andrade,S. Cordova,E.J. Soberon,X. Gonzalez-Villalpando,M.E. Henderson,E. Wilkens,L.R. Le Marchand,L. Arellano-Campos,O. Ordonez-Sanchez,M.L. Rodriguez-Torres,M. Rodriguez-Guillen,R. Riba,L. Najmi,L.A. Jacobs,S.B. Fennell,T. Gabriel,S. Fontanillas,P. Hanis,C.L. Lehman,D.M. Jenkinson,C.P. Abboud,H.E. Bell,G.I. Cortes,M.L. Boehnke,M. Gonzalez-Villalpando,C. Orozco,L. Haiman,C.A. Tusie-Luna,T. Aguilar-Salinas,C.A. Altshuler,D. Njolstad,P.R. Florez,J.C. Macarthur,D.G. 2014. Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population JAMA, 311, 2305-2314 * .

Williams,A.L. Jacobs,S.B. Moreno-Macias,H. Huerta-Chagoya,A. Churchhouse,C. Marquez-Luna,C. Garcia-Ortiz,H. Gomez-Vazquez,M.J. Burtt,N.P. Aguilar-Salinas,C.A. Gonzalez-Villalpando,C. Florez,J.C. Orozco,L. Haiman,C.A. Tusie-Luna,T. Altshuler,D. Williams,A.L. Marquez-Luna,C. Huerta-Chagoya,A. Ripke,S. Gomez-Vazquez,M.J. Manning,A.K. Moreno-Macias,H. Garcia-Ortiz,H. Neale,B. Burtt,N.P. Aguilar-Salinas,C.A. Reich,D. Stram,D.O. Fernandez-Lopez,J.C. Romero-Hidalgo,S. Altshuler,D. Florez,J.C. Tusie-Luna,T. Patterson,N. Haiman,C.A. Aguilar-Delfin,I. Martinez-Hernandez,A. Centeno-Cruz,F. Mendoza-Caamal,E. Revilla-Monsalve,C. Islas-Andrade,S. Cordova,E. Rodriguez-Arellano,E. Soberon,X. Orozco,L. Florez,J.C. Gonzalez-Villalpando,C. Gonzalez-Villalpando,M.E. Haiman,C.A. Henderson,B.E. Monroe,K. Wilkens,L. Kolonel,L.N. Le Marchand,L. Riba,L. Ordonez-Sanchez,M.L. Rodriguez-Guillen,R. Cruz-Bautista,I. Rodriguez-Torres,M. Munoz-Hernandez,L.L. Saenz,T. Gomez,D. Alvirde,U. Burtt,N.P. Onofrio,R.C. Brodeur,W.M. Gage,D. Murphy,J. Franklin,J. Mahan,S. Ardlie,K. Crenshaw,A.T. Winckler,W. Prufer,K. Shunkov,M.V. Sawyer,S. Stenzel,U. Kelso,J. Lek,M. Sankararaman,S. Williams,A.L. Patterson,N. Macarthur,D.G. Reich,D. Derevianko,A.P. Paabo,S. Jacobs,S.B. Churchhouse,C. Gopal,S. Grammatikos,J.A. Smith,I.C. Bullock,K.H. Deik,A.A. Souza,A.L. Pierce,K.A. Clish,C.B. Altshuler,D. Fennell,T. Farjoun,Y. Genomics,P.B. Gabriel,S. Stram,D.O. Gross,M.D. Pereira,M.A. Seielstad,M. Koh,W.P. Tai,E.S. Flannick,J. Fontanillas,P. Morris,A. Teslovich,T.M. Burtt,N.P. Atzmon,G. Blangero,J. Bowden,D.W. Chambers,J. Shin,C.Y. Duggirala,R. Glaser,B. Hanis,C. Kooner,J. Laakso,M. Lee,J.Y. Tai,E.S. Ying,T.Y. Wilson,J.G. Haiman,C.A. Henderson,B.E. Monroe,K. Wilkens,L. Kolonel,L.N. Le Marchand,L. Puppala,S. Farook,V.S. Thameem,F. Abboud,H.E. Defronzo,R.A. Jenkinson,C.P. Lehman,D.M. Curran,J.E. Blangero,J. Duggirala,R. Burtt,N.P. Cortes,M.L. Altshuler,D. Florez,J.C. Haiman,C.A. Henderson,B.E. Aguilar-Salinas,C.A. Gonzalez-Villalpando,C. Orozco,L. Tusie-Luna,T. 2014. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico Nature, 506, 97-101 * .

Ochoa-Leyva,A. Montero-Moran,G. Saab-Rincon,G. Brieba,L.G. Soberon,X. 2013. Alternative Splice Variants in TIM Barrel Proteins from Human Genome Correlate with the Structural and Evolutionary Modularity of this Versatile Protein Fold PLoS ONE, 8, e70582.

Tsai,I.J. Zarowiecki,M. Holroyd,N. Garciarrubio,A. Sanchez-Flores,A. Brooks,K.L. Tracey,A. Bobes,R.J. Fragoso,G. Sciutto,E. Aslett,M. Beasley,H. Bennett,H.M. Cai,J. Camicia,F. Clark,R. Cucher,M. De Silva,N. Day,T.A. Deplazes,P. Estrada,K. Fernandez,C. Holland,P.W.H. Hou,J. Hu,S. Huckvale,T. Hung,S.S. Kamenetzky,L. Keane,J.A. Kiss,F. Koziol,U. Lambert,O. Liu,K. Luo,X. Luo,Y. Macchiaroli,N. Nichol,S. Paps,J. Parkinson,J. Pouchkina-Stantcheva,N. Riddiford,N. Rosenzvit,M. Salinas,G. Wasmuth,J.D. Zamanian,M. Zheng,Y. Cai,X. Soberon,X. Olson,P.D. Laclette,J.P. Brehm,K. Berriman,M. Ochoa-Leyva,A. 2013. The genomes of four tapeworm species reveal adaptations to parasitism Nature, 496, 57-63.

Lopez-de Los Santos Y. Chan,H. Cantu,V.A. Rettner,R. Sanchez,F. Zhang,Z. Saier,M.H. Soberon,X. 2012. Genetic engineering of the phosphocarrier protein NPr of the Escherichia coli phosphotransferase system selectively improves sugar uptake activity Journal of Biological Chemistry, 287, 29931-29939.

Saab-Rincon,G. Olvera,L. Olvera,M. Rudino-Pinera,E. Benites,E. Soberon,X. Morett,E. 2012. Evolutionary Walk between (beta/alpha)(8) Barrels: Catalytic Migration from Triosephosphate Isomerase to Thiamin Phosphate Synthase Journal of Molecular Biology, 416, 255-270.

Ochoa-Leyva,A. Barona-Gomez,F. Saab-Rincon,G. Verdel-Aranda,K. Sanchez,F. Soberon,X. 2011. Exploring the Structure-Function Loop Adaptability of a (beta/alpha)(8)-Barrel Enzyme through Loop Swapping and Hinge Variability Journal of Molecular Biology, 411, 143-157.

Noda-Garcia,L. Camacho-Zarco,A.R. Verdel-Aranda,K. Wright,H. Soberon,X. Fulop,V. Barona-Gomez,F. 2010. Identification and analysis of residues contained on beta --> alpha loops of the dual-substrate (betaalpha)(8) phosphoribosyl isomerase a (PriA) specific for its phosphoribosyl anthranilate isomerase activity Protein Science, 19, 535-543.

Ochoa-Leyva,A. Soberon,X. Sanchez,F. Arguello,M. Montero-Moran,G. Saab-Rincon,G. 2009. Protein design through systematic catalytic loop exchange (SCLE) in the (beta/alpha)(8)-fold Journal of Molecular Biology, 387, 949-964.

Damian-Almazo,J.Y. Lopez-Munguia A. Soberon-Mainero,X. Saab-Rincon,G. 2008. Role of the phenylalanine 260 residue in defining product profile and alcoholytic activity of the a-amylase AmyA from Thermotoga maritima Biologia, 63, 1035-1043.

Damian-Almazo,J.Y. Moreno,A. Lopez-Munguia,A. Soberon,X. Gonzalez-Munoz,F. Saab-Rincon,G. 2008. Enhancement of the alcoholytic activity of {alpha}-amylase AmyA from Thermotoga maritima MSB8 (DSM 3109) by site directed mutagenesis Applied and Environmental Microbiology, 74, 5168-5177.

Vazquez-Limon,C. Vega-Badillo,J. Martinez,A. Espinosa-Molina,G. Gosset,G. Soberon,X. Lopez-Munguia,A. Osuna,J. 2007. Growth rate of a non-fermentative Escherichia coli strain is influenced by NAD(+) regeneration Biotechnology Letters, 29, 1857-1863.

Flores-Ramirez,G. Rivera,M. Morales-Pablos,A. Osuna,J. Soberon,X. Gaytan,P. 2007. The effect of amino acid deletions and substitutions in the longest loop of GFP BMC Chemical Biology, 7, 1.

Soberon,X. Saier,M.H., Jr. 2006. Engineering Transport Protein Function: Theoretical and Technical Considerations Using the Sugar-Transporting Phosphotransferase System of Escherichia coli as a Model System Journal of Molecular Microbiology and Biotechnology, 11, 302-307.

Monroy-Lagos,O. Soberon,X. Gaytan,P. Osuna,J. 2006. Improvement of an unusual twin-arginine transporter leader Peptide by a codon-based randomization approach Applied and Environmental Microbiology, 72, 3797-3801.

Souza,V. Espinosa-Asuar,L. Escalante,A.E. Eguiarte,L.E. Farmer,J. Forney,L. Lloret,L. Rodriguez-Martinez,J.M. Soberon,X. Dirzo,R. Elser,J.J. 2006. An endangered oasis of aquatic microbial biodiversity in the Chihuahuan desert Proceedings of the National Academy of Sciences of the United States of America, 103, 6565-6570.

Aguilar-Diaz,H. Bobes,R.J. Carrero,J.C. Camacho-Carranza,R. Cervantes,C. Cevallos,M.A. Davila,G. Rodriguez-Dorantes,M. Escobedo,G. Fernandez,J.L. Fragoso,G. Gaytan,P. Garciarrubio,A. Gonzalez,V.M. Gonzalez,L. Jose,M.V. Jimenez,L. Laclette,J.P. Landa,A. Larralde,C. Morales-Montor,J. Morett,E. Ostoa-Saloma,P. Sciutto,E. Santamaria,R.I. Soberon,X. de la Torre P. Valdes,V. Yanez,J. 2006. The genome project of Taenia solium Parasitology International, 55, S127-S130.

Gaytan,P. Yanez,J. Grande,R. Morett,E. Soberon,X. 2005. Improving random mutagenesis by purification of the oligonucleotide variants Combinatorial Chemistry & High Throughput Screening, 8, 537-544.

Saab-Rincon,G. Mancera,E. Montero-Moran,G. Sanchez,F. Soberon,X. 2005. Generation of variability by in vivo recombination of halves of a (beta/alpha)(8) barrel protein Biomolecular Engineering, 22, 113-120.

Yanez,J. Arguello,M. Osuna,J. Soberon,X. Gaytan,P. 2004. Combinatorial codon-based amino acid substitutions Nucleic Acids Research, 32, e158.

Osuna,J. Yanez,J. Soberon,X. Gaytan,P. 2004. Protein evolution by codon-based random deletions Nucleic Acids Research, 32, e136.

Baez-Viveros,J.L. Osuna,J. Hernandez-Chavez,G. Soberon,X. Bolivar,F. Gosset,G. 2004. Metabolic engineering and protein directed evolution increase the yield of L-phenylalanine synthesized from glucose in Escherichia coli Biotechnology and Bioengineering, 87, 516-524.

Moreno,A. Saab-Rincon,G. Santamaria,R.I. Soberon,X. Lopez-Munguia,A. 2004. A more efficient starch degradation by the combination of hydrolase and transferase activities of alpha-amylase and cyclomaltodextrin glucanotransferase Starch-Starke, 56, 63-68.

Flores,G. Soberon,X. Osuna,J. 2004. Production of a fully functional, permuted single-chain penicillin G acylase Protein Science, 13, 1677-1683.

Soberon,X. Fuentes-Gallego,P. Saab-Rincon,G. 2004. In vivo fragment complementation of a (beta/alpha)(8) barrel protein: generation of variability by recombination FEBS Letters, 560, 167-172.

Rivera,M.H. Lopez-Munguia,A. Soberon,X. Saab-Rincon,G. 2003. alpha-Amylase from Bacillus licheniformis mutants near to the catalytic site: effects on hydrolytic and transglycosylation activity Protein Engineering, 16, 505-514.

Gaytan,P. Osuna,J. Soberon,X. 2002. Novel ceftazidime-resistance beta-lactamases generated by a codon-based mutagenesis method and selection Nucleic Acids Research, 30, e84-e84.

Osuna,J. Perez-Blancas,A. Soberon,X. 2002. Improving a circularly permuted TEM-1 beta-lactamase by directed evolution Protein Engineering, 15, 463-470.

Gaytan,P. Yanez,J. Sanchez,F. Soberon,X. 2001. Orthogonal combinatorial mutagenesis: a codon-level combinatorial mutagenesis method useful for low multiplicity and amino acid-scanning protocols Nucleic Acids Research, 29, E9.

Saab-Rincon,G. Juarez,V.R. Osuna,J. Sanchez,F. Soberon,X. 2001. Different strategies to recover the activity of monomeric triosephosphate isomerase by directed evolution Protein Engineering, 14, 149-155.

Santamaria,R.I. Del Rio,G. Saab,G. Rodriguez,M.E. Soberon,X. Lopez-Manguia,A. 1999. Alcoholysis reactions from starch with alpha-amylases FEBS Letters, 452, 346-350.

Saab-Rincon,G. Del Rio,G. Santamaria,R.I. Lopez-Munguia,A. Soberon,X. 1999. Introducing transglycosylation activity in a liquefying alpha-amylase FEBS Letters, 453, 100-106.

Moreno-Hagelsieb,G. Gomez-Puyou,A. Soberon,X. 1999. Escherichia coli TEM1 beta-lactamase in CTAB reverse micelles: exchange/diffusion-limited catalysis FEBS Letters, 459, 111-114.

Gonzalez,V. Olvera,L. Soberon,X. Morett,E. 1998. In vivo studies on the positive control function of NifA: a conserved hydrophobic amino acid patch at the central domain involved in transcriptional activation Molecular Microbiology, 28, 55-67.

Gaytan,P. Yanez,J. Sanchez,F. Mackie,H. Soberon,X. 1998. Combination of DMT-mononucleotide and Fmoc-trinucleotide phosphoramidites in oligonucleotide synthesis affords an automatable codon-level mutagenesis method Chemistry and Biology, 5, 519-527.

Garcia,J.L. Nunez,C.J. Gonzalez,E.G. Osuna,J. Soberon,X. Galindo,E. 1998. Microbial sensor for new-generation cephalosporins based in a protein-engineered beta-lactamase Applied Biochemistry and Biotechnology, 73, 243-256.

Galindo,E. Lagunas,F. Osuna,J. Soberon,X. Garcia,J.L. 1998. A microbial biosensor for 6-aminopenicillanic acid Enzyme and Microbial Technology, 23, 331-334.

Osuna,J. Soberon,X. Morett,E. 1997. A proposed architecture for the central domain of the bacterial enhancer-binding proteins based on secondary structure prediction and fold recognition Protein Science, 6, 543-555.

Flores,H. Soberon,X. Sanchez,J. Bravo,A. 1997. Isolated domain II and III from the Bacillus thuringiensis Cry1Ab delta-endotoxin binds to lepidopteran midgut membranes FEBS Letters, 414, 313-318.

Del Rio,G. Morett,E. Soberon,X. 1997. Did cyclodextrin glycosyltransferases evolve from alpha-amylases? FEBS Letters, 416, 221-224.

Muir,R.S. Flores,H. Zinder,N.D. Model,P. Soberon,X. Heitman,J. 1997. Temperature-sensitive mutants of the EcoRI endonuclease Journal of Molecular Biology, 274, 722-737.

Gaytan,P. Yanez,J. Soberon,X. Martinez,R. 1997. A new method for oligonucleotide derivatization of the 3' or 5'-termini with a CPG-support carrying the natural product isoargentatin-D Tetrahedron Letters, 38, 6123-6126.

Moreno-Hagelsieb,G. Soberon,X. 1996. Protein engineering as a powerful tool for the chemical modification of enzymes Biological Research, 29, 127-140.

Del Rio,G. Lopez-Munguia,A. Soberon,X. 1996. An engineered penicillin acylase with altered surface charge is more stable in alkaline pH Annals of the New York Academy of Sciences, 799, 61-64.

Osuna,J. Viadiu,H. Fink,A.L. Soberon,X. 1995. Substitution of Asp for Asn at position 132 in the active site of TEM beta-lactamase. Activity toward different substrates and effects of neighboring residues Journal of Biological Chemistry, 270, 775-780.

Viadiu,H. Osuna,J. Fink,A.L. Soberon,X. 1995. A new TEM beta-lactamase double mutant with broadened specificity reveals substrate-dependent functional interactions Journal of Biological Chemistry, 270, 781-787.

Flores,H. Osuna,J. Heitman,J. Soberon,X. 1995. Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants Gene, 157, 295-301.

Del Rio,G. Rodriguez,M.E. Munguia,M.E. Lopez-Munguia,A. Soberon,X. 1995. Mutant Escherichia coli penicillin acylase with enhanced stability at alkaline pH Biotechnology and Bioengineering, 48, 141-148.

Osuna,J. Flores,H. Soberon,X. 1994. Microbial systems and directed evolution of protein activities Critical Reviews in Microbiology, 20, 107-116.

Gurrola,G.B. Moreno-Hagelsieb,G. Zamudio,F.Z. Garcia,M. Soberon,X. Possani,L.D. 1994. The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus FEBS Letters, 347, 59-62.

Del Rio,G. Osuna,J. Soberon,X. 1994. Combinatorial libraries of proteins: analysis of efficiency of mutagenesis techniques.Biotechniques, 17, 1132-1139.

Merino,E. Osuna,J. Bolivar,F. Soberon,X. 1992. A general, PCR-based method for single or combinatorial oligonucleotide-directed mutagenesis on pUC/M13 vectors.Biotechniques, 12, 508-510.

Pereyra-Alferez,B. Bravo,A. Quintero,R. Soberon,X. 1992. The delta-endotoxin protein family displays a hydrophobic motif that might be implicated in toxicity Molecular Microbiology, 6, 2095-2098.

Lopez,S. Lopez,I. Romero,P. Mendez,E. Soberon,X. Arias,C.F. 1991. Rotavirus YM gene 4: analysis of its deduced amino acid sequence and prediction of the secondary structure of the VP4 protein Journal of Virology, 65, 3738-3745.

Osuna,J. Flores,H. Soberon,X. 1991. Combinatorial mutagenesis of three major groove-contacting residues of EcoRI: single and double amino acid replacements retaining methyltransferase-sensitive activities Gene, 106, 7-12.

Fuchs,L.Y. Ovando,C. Joseph,P. Soberon,X. Charli,J.L. 1990. Repetitive DNA sequence from the crayfish Procambarus clarkii Nucleic Acids Research, 18, 1650.

Pastor,N. Pinero,D. Valdes,A.M. Soberon,X. 1990. Molecular evolution of class A beta-lactamases: phylogeny and patterns of sequence conservation Molecular Microbiology, 4, 1957-1965.

Balbas,P. Soberon,X. Bolivar,F. Rodriguez,R.L. 1988. The plasmid, pBR322.Biotechnology (Reading, Mass.), 10, 5-41.

Balbas,P. Soberon,X. Merino,E. Zurita,M. Lomeli,H. Valle,F. Flores,N. Bolivar,F. 1986. Plasmid vector pBR322 and its special-purpose derivatives--a review Gene, 50, 3-40.

Zurita,M. Bolivar,F. Soberon,X. 1984. Construction and characterization of new cloning vehicles. VII. Construction of plasmid pBR327par, a completely sequenced, stable derivative of pBR327 containing the par locus of pSC101 Gene, 28, 119-122.

Rossi,J.J. Soberon,X. Marumoto,Y. McMahon,J. Itakura,K. 1983. Biological expression of an Escherichia coli consensus sequence promoter and some mutant derivatives Proceedings of the National Academy of Sciences of the United States of America, 80, 3203-3207 * .

Miyada,C.G. Soberon,X. Itakura,K. Wilcox,G. 1982. The use of synthetic oligodeoxyribonucleotides to produce specific deletions in the araBAD promoter of Escherichia coli B/r Gene, 17, 167-177 * .

Inouye,S. Soberon,X. Franceschini,T. Nakamura,K. Itakura,K. Inouye,M. 1982. Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane Proceedings of the National Academy of Sciences of the United States of America, 79, 3438-3441 [corrections vol 79 p 6107, 79 p 4828] * .

Zarucki-Schulz,T. Tsai,S.Y. Itakura,K. Soberon,X. Wallace,R.B. Tsai,M.J. Woo,S.L. O'Malley,B.W. 1982. Point mutagenesis of the ovalbumin gene promoter sequence and its effect on in vitro transcription Journal of Biological Chemistry, 257, 11070-11077 * .

Covarrubias,L. Cervantes,L. Covarrubias,A. Soberon,X. Vichido,I. Blanco,A. Kupersztoch-Portnoy,Y.M. Bolivar,F. 1981. Construction and characterization of new cloning vehicles. V. Mobilization and coding properties of pBR322 and several deletion derivatives including pBR327 and pBR328 Gene, 13, 25-35 * .

Soberon,X. Covarrubias,L. Bolivar,F. 1980. Construction and characterization of new cloning vehicles. IV. Deletion derivatives of pBR322 and pBR325 Gene, 9, 287-305 * .

Libros y capítulos recientes

Soberon,X. Bergna,M. Valez,M.A. 2018. ¿Iguales o difererentes? Genomica. Ciudad de Mexico:. Editorial Tecolote.

Arias-Ortiz,C.F. Arteaga-Vazquez,M.A. Barrera-Saldana,H.A. Galindo-Fentanes,E. Gracia-Gasca,A. Herrera-Estrella,L.R. Higuera-Ciapara,I. Larque-Saavedra,F.A. Lopez-Munguia Canales,A. Ramirez-Reivich,O.T. Revah-Moiseev,S. Soberon-Mainero,X. Torres-Pacheco,I. Uribe de la Mora,J.M. Vazquez-Ramos,J.M. Viniegra-Gonzalez,G. 2017. Transgénicos: Grandes beneficios, ausencia de daños y mitos Comité de Biotecnología, Academia Mexicana de Ciencias-UNAM Instituto de Biotecnologia.

Soberon,X. 2012. La medicina genómica en México, consideraciones para su desarrollo. en: Garcia-Ayala,M.A. Fortalezas y desafíos de los servicios de salud de México en el siglo XXI.. Comité Ejecutivo Nacional de Trabajadores de la Secretaría de Salud. pags. 202-205

Bolivar-Zapata,F.G. Arias-Ortiz,C.F. Arriaga-Arellano,E. Barrera-Saldaña,H. de la Torres-Martinez,M. Espinosa-Fernandez,J. Galindo-Fentanes,E. Galvez-Mariscal,A. Gracia-Gasca,A. Herrera-Estrella,L. Larque-Saavedra,A. Lopez-Munguia Canales,A. Noyola-Robles,A. Paredes-Lopez,O. Ramirez-Reivich,O.T. Revah-Moiseev,S. Soberon-Mainero,J. Soberon-Mainero,X. Torres-Pacheco,I. Uribe de la Mora,J. Viniegra-Gonzalez,G. 2011. Por un uso responsable de los organismos genéticamente modificados Mexico:. Academia Mexicana de las Ciencias.

Frausto-Solis,J. Soberon-Mainero,X. Linan-Garcia,E. 2009. MultiQuenching annealing algorithm for protein folding problem en: Lecture Notes in Computer Science 5845. pags. 578-589

Segovia,L. Soberon,X. 2008. Evolución experimental de proteínas en: *agustin Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 26. Mexico, D.F.. UNAM. pags. 291-302

Frausto-Solis,J. Roman,E.F. Romero,D. Soberon,X. Linan-Garcia,E. 2007. Analytically tuned simulated annealing applied to the protein folding problem en: Lecture Notes in Computer Science vol 4488. pags. 370-377

Barona-Gomez,F. Ochoa-Leyva,A. Soberon,X. 2007. Advances and perspectives in protein engineering: from natural history to directed evolution of enzymes en: Fernandez-Velasco,D.A. Advances in Protein Physical Chemistry. Kerala. Research Signpost. pags. 407-438

Soberon,X. Montero,G.M. 2004. Ingeniería de proteínas y evolución dirigida en: *bolivar Fundamentos y casos exitosos de la biotecnologia moderna cap 7. Mexico. El Colegio Nacional. pags. 195-217

Soberon,X. 2003. Las proteínas en: Merchant-Larios,H. Biología Celular y Molecular. Mexico,D.F.. Prentice Hall. pags. 43-62

Soberon,X. 2003. Biocatálisis y evolución dirigida de proteínas en: *agustin Fronteras de la Biología en los Inicios del Siglo XXI, Módulo VII.. Mexico,D.F.. El Colegio Nacional. pags. 35-45

Gosset,G. Bolivar,F. Soberon,X. Lopez-Munguia,A. Valderrama,B. Ayala,M. Vazquez,R. Ramirez,O.T. Alagon,A. Possani,L.D. 2003. Fronteras de la Biología en los Inicios del Siglo XXI. Módulo VII: Ingeniería Celular, Biodiversidad e Industria. Mexico, D.F.: El Colegio Nacional.

Arias,C.F. Arriaga,E. Barrera,H. Bolivar,F. Bosch,P. De la Torre,M. Espinosa,J. Galindo,E. Galvez,A. Garcia,A. Herrera,L.R. Larque,A. Lopez-Munguia,A. Loyola,A. Ortega,R. Paredes.O. Ramirez,O.T. Revah,S. Serratos,J.A. Soberon,J. Soberon,X. Torres,I. Uribe,J. Viniegra,G. 2003. Recomendaciones para el Desarrollo y Consolidación de la Biotecnología en México Mexico,D.F.: Academia Mexicana de Ciencias, A.C..

Saab-Rincon,G. Del Rio,G. Santamaria,R. Diaz,M.L. Soberon,X. Lopez-Munguia,A. 2002. 54 en: Aguilera,J.M. Engineering and Food for the 21st Century. Proceedings of the Eighth International Congress on Engineering and Food. Boca Raton, Fla. CRC Press. pags. 913-924

Soberon,X. Bolivar,F. 2001. Evolucion de los conceptos de gen y genoma en: Blazquez-Graf,N. Ciencias de la vida. Siglo XXI. pags. 61-83

Otras Publicaciones

Soberon-Mainero,X. Gonzalez-Covarrubias,V. 2014. Enfermedades infecciosas, hacia una medicina personalizada Revista Digital Universitaria, 15, art 43 * .

Soberon-Mainero,X. Melendez-Zajgla,J. 2010. [The Instituto Nacional de Medicina Genomica. Vocation and challenges] Revista de Investigacion Clinica, 62, 391-392 * .

Baez-Viveros,J.L. Osuna,J. Hernandez-Chavez,G. Soberon,X. Bolivar,F. Gosset,G. 2006. Metabolic via engineering for the production of aromatic substances in Escherichia coli Revista Latinoamericana de Microbiologia, 48, 92.

Yanez,J. Soberon,X. Gaytan,P. 2004. Rutas alternas de síntesis para la preparación de Fmoc-Trinucleósido-Difosfato Fosforamiditos Revista de la Sociedad Química de México, 48, 26-37.

Soberon-Mainero,X. 2003. Veinte años del Instituto de Biotecnología Revista de la Universidad de México, 629, .

Soberon-Mainero,X. 2002. La ingenieria genética y un campo de aplicación: la biocatálisis y la industria química limpia. Mensaje Bioquimico, 26, 1-18.

Soberon,X. 2001. Nuevos paradigmas relacionados con la ciencia biologica experimental: implicaciones cientificas, tecnologicas y sociales. Revista Universidad de Mexico, 605-606, 59-63.

Soberon,X. 2001. La biotecnologia: un ejercito microscopico al servicio del hombre Hypatia, 2, 6-7.

Soberon,X. 2000. El convenio UNAM-INE-Diversa y el aprovechamiento de recursos geneticos.Biotecnologia, 5, 14-15.

Soberon,X. 2000. Imitar la naturaleza?.Como ves, 18, 30-33.

Soberon,X. 1999. Enzymes directly evolving toward commercial applications Nature Biotechnology, 17, 539-540.

Oliver,G. Balbas,P. Valle,F. Soberon,X. Bolivar,F. 1985. [Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli].Revista Latinoamericana de Microbiologia, 27, 141-150.

Patentes

J. Osuna, J.L. Báez, G. Hernández, F. G. Bolivar, X. Soberón y G. Gosset 2005 Versiones insensibles a inhibición alostérica y catalíticamente eficientes de la enzima corismato mutasa-prefenato deshidratasa y su aplicación para la producción de L-fenilalanina en microorganismos. México.

X. Soberón y P. Gaitán 2003 Fmoc-trinucleótido-fosforamiditos y su uso como unidades mutagénicas para la construcción de bibliotecas combinatorias enriquecidas con sustituciones de baja multiplicidad.UNAM México.

X. Soberón y P. Gaitán 2003 Método para la construcción de bibliotecas binomiales de oligodesoxirrubonucleótidos, mutagenizados a nivel de codón utilizando desoxinucleósido-fosforamiditos.UNAM México.

X. Soberón y P. Gaytán 2002 Method for the construction of binomial libraries of oligodeoxyribonucleotides, mutagenized at a codon level using deoxyribonucleoside-phosphoramidities.Europa Canadá 2,391,999 USA10/130,047 a .

X. Soberón y P. Gaytán 2000 Fmoc-trinucleotide-phosphoramidites and their use as mutagenic units for assembling of combinational libraries enriched with low multiplicity substitutions.UNAM Estados Unidos.

X. Soberón y P. Gaytán 2000 Método para la construcción de bibliotecas binomiales de oligodesoxirrubonucleótidos, mutagenizados a nivel de codón utilizando desoxinucleósido-fosforamiditos.UNAM PCT. (en trámite)

X. Soberón y P. Gayt·n 1999 Fmoc-trinucleótido-fosforamiditos y su uso como unidades mutagénicas para la construcción de bibliotecas combinatorias enriquecidas con sustituciones de baja multiplicidad.UNAM México.

X. Soberón y P. Gayt·n 1999 Método para la construcción de bibliotecas binomiales de oligodesoxirrubonucleótidos, mutagenizados a nivel de codón utilizando desoxinucleósido-fosforamiditos.UNAM México.

* Indica publicación con otra institución de adscripción