. Instituto de Biotecnologia UNAM

IBT-UNAM : Dra. Susana Castro Obregón

Dra. Susana Castro Obregón

ex-colaborador y/o ex-alumno
Tutor de Maestría y Doctorado
Nivel I del SNI
Grupo del Dr. Luis Fernando Covarrubias
Teléfonos
Oficina +52 (777) 329-1777 ext 38218.
desde la CDMX 562-27777 ext 38218
red UNAM 38218

Laboratorio +52 (777) 329-1777 ext 38217.
desde la CDMX 562-27777 ext 38217
red UNAM 38217

- Licenciatura: Investigacion Biomedica Básica , UNAM (1992)
- Maestría: Biotecnologia, UNAM (1994)
- Doctorado: Investigacion Biomedica Básica, UNAM (1997)
- Mención Honorífica en el examen de Licenciatura
- Mención Honorífica en el examen de Maestría
- Mención Honorífica en el examen de Doctorado
- Beca Fundacion UNAM para estudiantes distinguidos (1996)
- Latinamerican Pew Fellow 1998
- Humboldt Fellow 2009.
- The Burham Institute, La Jolla, California, E.U.A. (1997-1999)
- The Buck Insitute for Age Research, Novato, California, E.U.A. (1999-2003)
- Max-Planck-Institut für molekulare Genetik, Berlín, Alemania (2009-2010).

Publicaciones recientes

Perez-Estrada,J.R. Hernandez-Garcia,D. Leyva-Castro,F. Ramos-Leon,J. Osiris,C.B. Diaz-Munoz,M. Castro-Obregon,S. Ramirez-Solis,R. Garcia,C. Covarrubias,L. 2019. Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging Free Radical Biology and Medicine, 135, 102-115.

Klatt,S. Hartl,D. Fauler,B. Gagoski,D. Castro-Obregon,S. Konthur,Z. 2013. Generation and characterization of a Leishmania tarentolae strain for site-directed in-vivo biotinylation of recombinant proteins Journal of Proteome Research, 12, 5512-5519.

Bouzas-Rodriguez,J. Zarraga-Granados,G. Sanchez-Carbente,M.R. Rodriguez-Valentin,R. Gracida,X. Anell-Rendon,D. Covarrubias,L. Castro-Obregon,S. 2012. The Nuclear Receptor NR4A1 Induces a Form of Cell Death Dependent on Autophagy in Mammalian Cells PLoS ONE, 7, e46422 [correction 10 (3) e0118718].

Rodriguez-Plaza,J.G. Villalon-Rojas A. Herrera,S. Garza-Ramos,G. Torres-Larios A. Amero,C. Zarraga-Granados,G. Gutierrez-Aguilar M. Lara-Ortiz,M.T. Polanco-Gonzalez C. Uribe-Carvajal S. Coria,R. Pena-Diaz A. Bredesen,D.E. Castro-Obregon,S. Del Rio,G. 2012. Moonlighting peptides with emerging function PLoS ONE, 7, e40125 [correction in 2013 Oct 23;8(10)].

Valbuena,A. Castro-Obregon,S. Lazo,P.A. 2011. Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway PLoS ONE, 6, e17320.

Hernandez-Garcia,D. Wood,C.D. Castro-Obregon,S. Covarrubias,L. 2010. Reactive oxygen species: A radical role in development? Free Radical Biology and Medicine, 49, 130-143.

Hernandez-Martinez,R. Castro-Obregon,S. Covarrubias,L. 2009. Progressive interdigital cell death: regulation by the antagonistic interaction between fibroblast growth factor 8 and retinoic acid Development, 136, 3669-3678.

Mille,F. Llambi,F. Guix,C. dEloye-Bourgeois,C. Guenebeaud,C. Castro-Obregon,S. Bredesen,D.E. Thibert,C. Mehlen,P. 2009. Interfering with multimerization of netrin-1 receptors triggers tumor cell death Cell Death and Differentiation, 16, 1344-1351 * .

Covarrubias,L. Hernandez-Garcia,D. Schnabel,D. Salas-Vidal,E. Castro-Obregon,S. 2008. Function of reactive oxygen species during animal development: Passive or active? Developmental Biology, 320, 1-11.

Hernandez-Garcia,D. Castro-Obregon,S. Gomez-Lopez,S. Valencia,C. Covarrubias,L. 2008. Cell death activation during cavitation of embryoid bodies is mediated by hydrogen peroxide Experimental Cell Research, 314, 2090-2099.

Sanchez-Carbente,M.R. Castro-Obregon,S. Covarrubias,L. Narvaez,V. 2005. Motoneuronal death during spinal cord development is mediated by oxidative stress Cell Death and Differentiation, 12, 279-291.

Rao,R.V. Poksay,K.S. Castro-Obregon,S. Schilling,B. Row,R.H. Del Rio,G. Gibson,B.W. Ellerby,H.M. Bredesen,D.E. 2004. Molecular components of a cell death pathway activated by endoplasmic reticulum stress Journal of Biological Chemistry, 279, 177-187 * .

Castro-Obregon,S. Rao,R.V. Del Rio,G. Chen,S.F. Poksay,K.S. Rabizadeh,S. Vesce,S. Zhang,X.K. Swanson,R.A. Bredesen,D.E. 2004. Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77 Journal of Biological Chemistry, 279, 17543-17553 * .

Gresch,O. Engel,F.B. Nesic,D. Tran,T.T. England,H.M. Hickman,E.S. Korner,I. Gan,L. Chen,S. Castro-Obregon,S. Hammermann,R. Wolf,J. Muller-Hartmann,H. Nix,M. Siebenkotten,G. Kraus,G. Lun,K. 2004. New non-viral method for gene transfer into primary cells Methods, 33, 151-163 * .

Rao,R.V. Castro-Obregon,S. Frankowski,H. Schuler,M. Stoka,V. Del Rio,G. Bredesen,D.E. Ellerby,H.M. 2002. Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway Journal of Biological Chemistry, 277, 21836-21842 * .

Frankowski,H. Castro-Obregon,S. Del Rio,G. Rao,R.V. Bredesen,D.E. 2002. PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor Neuromolecular.Med, 1, 153-170 * .

Castro-Obregon,S. Del Rio,G. Chen,S.F. Swanson,R.A. Frankowski,H. Rao,R.V. Stoka,V. Vesce,S. Nicholls,D.G. Bredesen,D.E. 2002. A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death Cell Death and Differentiation, 9, 807-817 * .

Del Rio,G. Castro-Obregon,S. Rao,R. Ellerby,H.M. Bredesen,D.E. 2001. APAP, a sequence-pattern recognition approach identifies substance P as a potential apoptotic peptide FEBS Letters, 494, 213-219 * .

Rao,R.V. Hermel,E. Castro-Obregon,S. Del Rio,G. Ellerby,L.M. Ellerby,H.M. Bredesen,D.E. 2001. Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation Journal of Biological Chemistry, 276, 33869-33874 * .

Salas-Vidal,E. Lomeli,H. Castro-Obregon,S. Cuervo,R. Escalante-Alcalde,D. Covarrubias,L. 1998. Reactive oxygen species participate in the control of mouse embryonic cell death Experimental Cell Research, 238, 136-147.

Castro-Obregon,S. Covarrubias,L. 1996. Role of retinoic acid and oxidative stress in embryonic stem cell death and neuronal differentiation FEBS Letters, 381, 93-97.

Escalante-Alcalde,D. Recillas-Targa,F. Hernandez-Garcia,D. Castro-Obregon,S. Terao,M. Garattini,E. Covarrubias,L. 1996. Retinoic acid and methylation cis-regulatory elements control the mouse tissue non-specific alkaline phosphatase gene expression Mechanisms of Development, 57, 21-32.

Salas-Vidal,E. Plebanski,M. Castro,S. Perales,G. Mata,E. Lopez,S. Arias,C.F. 1990. Synthesis of the surface glycoprotein of rotavirus SA11 in the aroA strain of Salmonella typhimurium SL3261 Research in Microbiology, 141, 883-886.

Swanson,S. Castro-Obregon,S. 2014. Cell Death en: Daroff,R. Encyclopedia of the Neurological Sciences. Elsevier. pags. 634-636

Castro-Obregon,S. 2012. La Autofagia en el proceso de el Envejecimiento en: Torres-Carrillo,N.M. Aspectos Moleculares del Envejecimiento. Mexico. Instituto de Geriatría. pags. 101-110

Covarrubias,L. Castro-Obregon,S. 2008. Degeneración y regeneración tisular: de la embriogénesis a la medicina regenerativa en: *agustin Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 13. Mexico, D.F.. UNAM. pags. 145-158

Castro-Obregon,S. Covarrubias,L. 2007. Types of cell death: basic mechanisms, en: Moran,J. Neurochemistry of neuronal death. Kerala. Research Signpost.

Swanson,S. Castro-Obregon,S. 2003. Cell Death en: Daroff,R. Encyclopedia of the Neurological Sciences. Elsevier. pags. 542-545 *

Otras Publicaciones

Castro-Obregon,S. 2010. Discovery of Lysosomes and Autophagy Nature Education, 3, 49.

* Indica publicación con otra institución de adscripción