Santibanez-Lopez,C.E. Cid-Uribe,J.I. Batista,C.V. Ortiz,E. Possani,L.D.
2016. Venom Gland Transcriptomic and Proteomic Analyses of the Enigmatic Scorpion Superstitionia donensis (Scorpiones: Superstitioniidae), with Insights on the Evolution of Its Venom Components Toxins (Basel), 8, .
Osnaya-Romero N. Acosta-Saavedra,L.C. Goytia-Acevedo,R. Lares-Asseff,I. Basurto-Celaya,G. Perez-Guille,G. Possani,L.D. Calderon-Aranda,E.S.
2016. Serum level of scorpion toxins, electrolytes and electrocardiogram alterations in Mexican children envenomed by scorpion sting Toxicon, 122, 103-108.
Luna-Martinez,K. Jimenez-Vargas,J.M. Possani,L.D.
2016. Scorpine-Like Peptides Single Cell Biology, 5, .
Rodriguez-Rodriguez,E.R. Olamendi-Portugal,T. Serrano-Posada,H. Arredondo-Lopez,J.N. Gomez-Ramirez,I. Fernandez-Taboada,G. Possani,L.D. Vega,G.A. Riano-Umbarila,L. Becerril,B.
2016. Broadening the neutralizing capacity of a family of antibody fragments against different toxins from Mexican scorpions Toxicon, 119, 52-63.
Zhang,H. Du,M. Xie,J. Liu,X. Sun,J. Wang,W. Xin,X. Possani,L.D. Yea,K. Lerner,R.A.
2016. Autocrine-Based Selection of Drugs that Target Ion Channels from Combinatorial Venom Peptide Libraries Angewandte Chemie International Edition, 55, 9306-9310.
Valdez-Velazquez,L.L. Romero-Gutierrez,M.T. Delgado-Enciso,I. Dobrovinskaya,O. Melnikov,V. Quintero-Hernandez,V. Ceballos-Magana,S.G. Gaitan-Hinojosa,M.A. Coronas,F.I. Puebla-Perez,A.M. Zamudio,F. De la Cruz-Garcia,I. Vazquez-Vuelvas,O.F. Soriano-Hernandez,A.D. Possani,L.D.
2016. Comprehensive analysis of venom from the scorpion Centruroides tecomanus reveals compounds with antimicrobial, cytotoxic, and insecticidal activities Toxicon, 118, 95-103.
Xiao,L. Gurrola,G.B. Zhang,J. Valdivia,C.R. SanMartin,M. Zamudio,F.Z. Zhang,L. Possani,L.D. Valdivia,H.H.
2016. Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands Journal of General Physiology, 147, 375-394.
Olamendi-Portugal,T. Bartok,A. Zamudio-Zuniga,F. Balajthy,A. Becerril,B. Panyi,G. Possani,L.D.
2016. Isolation, chemical and functional characterization of several new K-channel blocking peptides from the venom of the scorpion Centruroides tecomanus Toxicon, 115, 1-12.
Figueroa-Montiel,A. Ramos,M.A. Mares,R.E. Duenas,S. Pimienta,G. Ortiz,E. Possani,L.D. Licea-Navarro,A.F.
2016. In Silico Identification of Protein Disulfide Isomerase Gene Families in the De Novo Assembled Transcriptomes of Four Different Species of the Genus Conus PLoS ONE, 11, e0148390.
Santibanez-Lopez,C.E. Francke,O.F. Ureta,C. Possani,L.D.
2016. Scorpions from Mexico: From Species Diversity to Venom Complexity Toxins (Basel), 8, 2.
Riano-Umbarila,L. Ledezma-Candanoza,L.M. Serrano-Posada,H. Fernandez-Taboada,G. Olamendi-Portugal,T. Rojas-Trejo,S. Gomez-Ramirez,I.V. Rudino-Pinera,E. Possani,L.D. Becerril,B.
2016. Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin Journal of Biological Chemistry, 291, 1619-1630.
Ramirez-Carreto,S. Jimenez-Vargas,J.M. Rivas-Santiago,B. Corzo,G. Possani,L.D. Becerril,B. Ortiz,E.
2015. Peptides from the scorpion Vaejovis punctatus with broad antimicrobial activity Peptides, 73, 51-59.
Santibanez-Lopez,C.E. Possani,L.D.
2015. Overview of the Knottin scorpion toxin-like peptides in scorpion venoms: Insights on their classification and evolution Toxicon, 107, 317-326.
Rodriguez-Ravelo,R. Batista,C.V. Coronas,F.I. Zamudio,F.Z. Hernandez-Orihuela,L. Espinosa-Lopez,G. Ruiz-Urquiola,A. Possani,L.D.
2015. Comparative proteomic analysis of male and female venoms from the Cuban scorpion Rhopalurus junceus Toxicon, 107, 327-334.
Ortiz,E. Possani,L.D.
2015. The unfulfilled promises of scorpion insectotoxins Journal of Venomous Animals and Toxins Including Tropical Diseases, 21, .
Luna-Ramirez,K. Quintero-Hernandez,V. Juarez-Gonzalez,V.R. Possani,L.D.
2015. Whole Transcriptome of the Venom Gland from Urodacus yaschenkoi Scorpion PLoS ONE, 10, e0127883.
Espino-Solis,G.P. Quintero-Hernandez,V. Olvera-Rodriguez,A. Calderon-Amador,J. Pedraza-Escalona,M. Licea-Navarro,A. Flores-Romo,L. Possani,L.D.
2015. Novel monoclonal antibody against alphaX subunit from horse CD11c/CD18 integrin Veterinary Immunology and Immunopathology, 164, 220-226.
Quintero-Hernandez,V. Ramirez-Carreto,S. Romero-Gutierrez,M.T. Valdez-Velazquez,L.L. Becerril,B. Possani,L.D. Ortiz,E.
2015. Transcriptome Analysis of Scorpion Species Belonging to the Vaejovis Genus PLoS ONE, 10, e0117188.
Okada,M. Corzo,G. Romero-Perez,G.A. Coronas,F. Matsuda,H. Possani,L.D.
2015. A pore forming peptide from spider Lachesana sp. venom induced neuronal depolarization and pain Biochimica et Biophysica Acta (BBA), 1850, 657-666.
Ortiz,E. Gurrola,G.B. Schwartz,E.F. Possani,L.D.
2015. Scorpion venom components as potential candidates for drug development Toxicon, 93, 125-135.
Coronas,F.I. Diego-Garcia,E. Restano-Cassulini,R. de Roodt,A.R. Possani,L.D.
2015. Biochemical and physiological characterization of a new Na-channel specific peptide from the venom of the Argentinean scorpion Tityus trivittatus Peptides, 68, 11-16.
Picco,C. Corzo,G. Possani,L.D. Prestipino,G.
2014. Interaction of the scorpion toxin Discrepin with Kv4.3 channels and A-type K channels in cerebellum granular cells Biochimica et Biophysica Acta, 1840, 2744-2751.
Pedraza-Escalona,M. Batista,C.V. Restano-Cassulini,R. Sandoval-Rios,M. Coronas,F.I. Possani,L.D.
2014. A proteomic analysis of the early secondary molecular effects caused by Cn2 scorpion toxin on neuroblastoma cells Journal of Proteomics, 111, 212-223.
Gonzalez-Morales,L. Pedraza-Escalona,M. Diego-Garcia,E. Restano-Cassulini,R. Batista,C.V. Gutierrez,M.C. Possani,L.D.
2014. Proteomic characterization of the venom and transcriptomic analysis of the venomous gland from the Mexican centipede Scolopendra viridis Journal of Proteomics, 111, 224-237.
Luna-Ramirez,K. Bartok,A. Restano-Cassulini,R. Quintero-Hernandez,V. Coronas,F. Christensen,J. Wright,C.E. Panyi,G. Possani,L.D.
2014. Structure, Molecular Modeling and Function of the First Potassium Channel Blocker, Urotoxin, Isolated from the Venom of the Australian Scorpion Urodacus Yaschenkoi Molecular Pharmacology, 86, 28-41.
Vergara,I. Pedraza-Escalona,M. Paniagua,D. Restano-Cassulini,R. Zamudio,F. Batista,C.V. Possani,L.D. Alagon,A.
2014. Eastern coral snake Micrurus fulvius venom toxicity in mice is mainly determined by neurotoxic phospholipases A Journal of Proteomics, 105, 295-306.
Ortiz,E. Rendon-Anaya,M. Rego,S.C. Schwartz,E.F. Possani,L.D.
2014. Antarease-like Zn-metalloproteases are ubiquitous in the venom of different scorpion genera Biochimica et Biophysica Acta (BBA), 1840, 1738-1746.
Rodriguez-Ravelo,R. Restano-Cassulini,R. Zamudio,F.Z. Coronas,F.I.V. Espinosa-Lopez,G. Possani,L.D.
2014. A K+ channel blocking peptide from the Cuban scorpion Rhopalurus garridoi Peptides, 53, 42-47.
Luna-Ramirez,K. Sani,M.A. Silva-Sanchez,J. Jimenez-Vargas,J.M. Reyna-Flores,F. Winkel,K.D. Wright,C.E. Possani,L.D. Separovic,F.
2014. Membrane Interactions and Biological Activity of Antimicrobial Peptides from Australian Scorpion Biochimica et Biophysica Acta, 1838, 2140-2148.
Riano-Umbarila,L. Olamendi-Portugal,T. Morelos-Juarez,C. Gurrola,G.B. Possani,L.D. Becerril,B.
2013. A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins Toxicon, 76, 370-376.
Abdel-Rahman,M.A. Quintero-Hernandez,V. Possani,L.D.
2013. Venom proteomic and venomous glands transcriptomic analysis of the Egyptian scorpion Scorpio maurus palmatus (Arachnida: Scorpionidae) Toxicon, 74, 193-207.
Quintero-Hernandez,V. Jimenez-Vargas,J.M. Gurrola,G.B. Valdivia,H.H. Possani,L.D.
2013. Scorpion venom components that affect ion-channels function Toxicon, 76, 328-342.
Rodriguez-Ravelo,R. Coronas,F.I. Zamudio,F.Z. Gonzalez-Morales,L. Lopez,G.E. Urquiola,A.R. Possani,L.D.
2013. The Cuban scorpion Rhopalurus junceus (Scorpiones, Buthidae): component variations in venom samples collected in different geographical areas Journal of Venomous Animals and Toxins Including Tropical Diseases, 19, 13.
Valdez-Velazquez,L.L. Quintero-Hernandez,V. Romero-Gutierrez,M.T. Coronas,F.I.V. Possani,L.D.
2013. Mass Fingerprinting of the Venom and Transcriptome of Venom Gland of Scorpion Centruroides tecomanus PLoS ONE, 8, .
Deuis,J.R. Zimmermann,K. Romanovsky,A.A. Possani,L.D. Cabot,P.J. Lewis,R.J. Vetter,I.
2013. An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na1.6 in peripheral pain pathways Pain, 154, 1749-1757.
Schwartz,E.F. Bartok,A. Schwartz,C.A. Papp,F. Gomez-Lagunas,F. Panyi,G. Possani,L.D.
2013. OcyKTx2, a new K-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum Peptides, 46, 40-46.
Bernaldez,J. Roman-Gonzalez,S.A. Martinez,O. Jimenez,S. Vivas,O. Arenas,I. Corzo,G. Arreguin,R. Garcia,D.E. Possani,L.D. Licea,A.
2013. A Conus regularis Conotoxin with a Novel Eight-Cysteine Framework Inhibits CaV2.2 Channels and Displays an Anti-Nociceptive Activity Marine Drugs, 11, 1188-1202.
Mourao,C.B. Heghinian,M.D. Barbosa,E.A. Mari,F. Bloch,C., Jr. Restano-Cassulini,R. Possani,L.D. Schwartz,E.F.
2013. Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment into the HWTX-II family Biochemistry, 52, 2440-2452.
Sanchez-Vasquez,L. Silva-Sanchez,J. Jimenez-Vargas,J.M. Rodriguez-Romero,A. Munoz-Garay,C. Rodriguez,M.C. Gurrola,G.B. Possani,L.D.
2013. Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin Biochimica et Biophysica Acta (BBA), 1830, 3427-3436.
Caliskan,F. Quintero-Hernandez,V. Restano-Cassulini,R. Coronas-Valderrama,F.I. Corzo,G. Possani,L.D.
2013. Molecular cloning and biochemical characterization of the first Na+-channel alpha-type toxin peptide (Acra4) from Androctonus crassicauda scorpion venom Biochimie, 95, 1216-1222.
Aguilar,M.B. Ortiz,E. Kaas,Q. Lopez-Vera,E. Becerril,B. Possani,L.D. de la Cotera,E.P.
2013. Precursor De13.1 from Conus delessertii defines the novel G gene superfamily Peptides, 41, 17-20.
Pedraza-Escalona,M. Possani,L.D.
2013. Scorpion beta-toxins and voltage-gated sodium channels: interactions and effects Frontiers in Bioscience, 18, 572-587.
Luna-Ramirez,K. Quintero-Hernandez,V. Vargas-Jaimes,L. Batista,C.V. Winkel,K. Possani,L.D.
2013. Characterization of the venom from the Australian scorpion Urodacus yaschenkoi: molecular mass analysis of components, cDNA sequences and peptides with antimicrobial activity Toxicon, 63, 44-54.
Garcia,F. Villegas,E. Espino-Solis,G.P. Rodriguez,A. Paniagua-Solis,J.F. Sandoval-Lopez,G. Possani,L.D. Corzo,G.
2013. Antimicrobial peptides from arachnid venoms and their microbicidal activity in the presence of commercial antibiotics Journal of Antibiotics, 66, 3-10.
Wang,X. Jimenez-Vargas,J.M. Xu,C. Possani,L.D. Zhu,S.
2012. Positive selection-guided mutational analysis revealing two key functional sites of scorpion ERG K(+) channel toxins Biochemical and Biophysical Research Communications, 429, 111-116.
Clement,H. Olvera,A. Rodriguez,M. Zamudio,F. Palomares,L.A. Possani,L.D. Odell,G.V. Alagon,A. Sanchez-Lopez,R.
2012. Identification, cDNA cloning and heterologous expression of a hyaluronidase from the tarantula Brachypelma vagans venom Toxicon, 60, 1223-1227.
Clement,H. Costa de Oliveira,V. Zamudio,F.Z. Lago,N.R. Valdez-Cruz,N.A. Valle,M.B. Alagon,A.C. Possani,L.D. de Roodt,A.R.
2012. Isolation, amino acid sequence and biological characterization of an "aspartic-49" phospholipase A(2) from Bothrops (Rhinocerophis) ammodytoides Venom Toxicon, 60, 1314-1323.
Rendon-Anaya,M. Delaye,L. Possani,L.D. Herrera-Estrella,A.
2012. Global Transcriptome Analysis of the Scorpion Centruroides noxius: New Toxin Families and Evolutionary Insights from an Ancestral Scorpion Species PLoS ONE, 7, e43331.
Rodriguez-Rodriguez,E.R. Ledezma-Candanoza,L.M. Contreras-Ferrat,L.G. Olamendi-Portugal,T. Possani,L.D. Becerril,B. Riano-Umbarila,L.
2012. A Single Mutation in Framework 2 of the Heavy Variable Domain Improves the Properties of a Diabody and a Related Single-Chain Antibody Journal of Molecular Biology, 423, 337-350.
Caliskan,F. Garcia,B.I. Coronas,F.I. Restano-Cassulini,R. Korkmaz,F. Sahin,Y. Corzo,G. Possani,L.D.
2012. Purification and cDNA cloning of a novel neurotoxic peptide (Acra3) from the scorpion Androctonus crassicauda Peptides, 37, 106-112.
Varga,Z. Gurrola-Briones,G. Papp,F. Rodriguez de la Vega,R.C. Pedraza-Alva,G. Tajhya,R.B. Gaspar,R. Cardenas,L. Rosenstein,Y. Beeton,C. Possani,L.D. Panyi,G.
2012. Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells Molecular Pharmacology, 82, 372-382.
Gurrola,G.B. Hernandez-Lopez,R.A. Rodriguez de la Vega,R.C. Varga,Z. Batista,C.V. Salas-Castillo,S.P. Panyi,G. del Rio-Portilla,F. Possani,L.D.
2012. Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes Biochemistry, 51, 4049-4061.
Jimenez-Vargas,J.M. Restano-Cassulini,R. Possani,L.D.
2012. Toxin modulators and blockers of hERG K(+) channels Toxicon, 60, 492-501.
Jimenez-Vargas,J.M. Restano-Cassulini,R. Possani,L.D.
2012. Interacting sites of scorpion toxin ErgTx1 with hERG1 K(+) channels Toxicon, 59, 633-641.
Guerrero-Vargas,J.A. Mourao,C.B. Quintero-Hernandez,V. Possani,L.D. Schwartz,E.F.
2012. Identification and Phylogenetic Analysis of Tityus pachyurus and Tityus obscurus Novel Putative Na-Channel Scorpion Toxins PLoS ONE, 7, e30478.
Ramirez-Carreto,S. Quintero-Hernandez,V. Jimenez-Vargas,J.M. Corzo,G. Possani,L.D. Becerril,B. Ortiz,E.
2012. Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae Peptides, 34, 290-295.
Quintero-Hernandez,V. Del Pozo-Yauner,L. Pedraza-Escalona,M. Juarez-Gonzalez,V.R. Alcantara-Recillas,I. Possani,L.D. Becerril,B.
2012. Evaluation of three different formats of a neutralizing single chain human antibody against toxin Cn2: Neutralization capacity versus thermodynamic stability Immunology Letters, 143, 152-160.
Saucedo,A.L. Del Rio,F. Picco,C. Estrada,G. Prestipino,G. Possani,L.D. Delepierre,M. Corzo,G.
2012. Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion suffusus, and their effects on Nav1.5 Sodium channels Biochimica et Biophysica Acta (BBA), 1824, 478-487.
Caliskan,F. Quintero-Hernandez,V. Restano-Cassulini,R. Batista,C.V.F. Zamudio,F.Z. Coronas,F.I. Possani,L.D.
2012. Turkish scorpion Buthacus macrocentrus: General characterization of the venom and description of Bu1, a potent mammalian Na+-channel a-toxin Toxicon, 59, 408-415.
Saucedo,A.L. Flores-Solis,D. Rodriguez de la Vega,R.C. Ramirez-Cordero,B. Hernandez-Lopez,R. Cano-Sanchez,P. Noriega-Navarro,R. Garcia-Valdes,J. Coronas-Valderrama,F. de Roodt,A. Brieba,L.G. Possani,L.D. del Rio-Portilla,F.
2012. New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing Journal of Biological Chemistry, 287, 12321-12330.
Schiavon,E. Pedraza-Escalona,M. Gurrola,G.B. Olamendi-Portugal,T. Corzo,G. Wanke,E. Possani,L.D.
2012. Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels Toxicon, 59, 283-293.
Quintero-Hernandez,V. Ortiz,E. Rendon,M.R. Schwartz,E.F. Becerril,B. Corzo,G. Possani,L.D.
2011. Scorpion and spider venom peptides: Gene cloning and peptide expression Toxicon, 58, 644-663.
Camargos,T.S. Restano-Cassulini,R. Possani,L.D. Peigneur,S. Tytgat,J. Schwartz,C.A. de Freitas,S.M. Schwartz,E.F.
2011. The new kappa-KTx 2.5 from the scorpion Opisthacanthus cayaporum Peptides, 32, 1509-1517.
Amaro,I. Riano-Umbarila,L. Becerril,B. Possani,L.D.
2011. Isolation and characterization of a human antibody fragment specific for Ts1 toxin from Tityus serrulatus scorpion Immunology Letters, 139, 73-79.
Garcia-Gomez,B.I. Coronas,F.I. Restano-Cassulini,R. Rodriguez,R.R. Possani,L.D.
2011. Biochemical and molecular characterization of the venom from the Cuban scorpion Rhopalurus junceus Toxicon, 58, 18-27.
Canul-Tec,J.C. Riano-Umbarila,L. Rudino-Pinera,E. Becerril,B. Possani,L.D. Torres-Larios,A.
2011. Structural basis of neutralization of the major toxic component from the scorpion centruroides noxius hoffmann by a human-derived single chain antibody fragment Journal of Biological Chemistry, 286, 20892-20900.
Espino-Solis,G.P. Estrada,G. Olamendi-Portugal,T. Villegas,E. Zamudio,F. Cestele,S. Possani,L.D. Corzo,G.
2011. Isolation and molecular cloning of beta-neurotoxins from the venom of the scorpion Centruroides suffusus suffusus Toxicon, 57, 739-746.
Riano-Umbarila,L. Contreras-Ferrat,G. Olamendi-Portugal,T. Morelos-Juarez,C. Corzo,G. Possani,L.D. Becerril,B.
2011. Exploiting cross-reactivity to neutralize two different scorpion venoms with one single-chain antibody fragment Journal of Biological Chemistry, 286, 6143-6151.
Estrada,G. Restano-Cassulini,R. Ortiz,E. Possani,L.D. Corzo,G.
2011. Addition of positive charges at the C-terminal peptide region of CssII; a mammalian scorpion peptide toxin; improves its affinity for sodium channels Nav1.6 Peptides, 32, 75-79 (Correction vol 32 p.1096).
Hernandez-Aponte,C.A. Silva-Sanchez,J. Quintero-Hernandez,V. Rodriguez-Romero,A. Balderas,C. Possani,L.D. Gurrola,G.B.
2011. Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus Toxicon, 57, 84-92.
Jimenez-Vargas,J.M. Restano-Cassulini,R. Quintero-Hernandez,V. Gurrola,G.B. Possani,L.D.
2011. Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function Peptides, 32, 560-567.
Corrales-Garcia,L.L. Possani,L.D. Corzo,G.
2011. Expression systems of human beta-defensins: vectors, purification and biological activities Amino Acids, 40, 5-13.
Rodriguez,A. Villegas,E. Satake,H. Possani,L.D. Corzo,G.
2011. Amino acid substitutions in an alpha-helical antimicrobial arachnid peptide affect its chemical properties and biological activity towards pathogenic bacteria but improves its therapeutic index Amino Acids, 40, 61-68.
Gurrola,G.B. Capes,E.M. Zamudio,F.Z. Possani,L.D. Valdivia,H.H.
2010. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors Pharmaceuticals.(Basel), 3, 1093-1107.
Vandendriessche,T. Olamendi-Portugal,T. Zamudio,F.Z. Possani,L.D. Tytgat,J.
2010. Isolation and characterization of two novel scorpion toxins: the alpha-toxin-like CeII8, specific for Na(v)1.7 channels and the classical anti-mammalian CeII9, specific for Na(v)1.4 channels Toxicon, 56, 613-623.
Zhu,S. Gao,B. Aumelas,A. Rodriguez,M.D. Lanz-Mendoza,H. Peigneur,S. Diego-Garcia,E. Martin-Eauclaire,M.F. Tytgat,J. Possani,L.D.
2010. MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity Biochimica et Biophysica Acta (BBA) Proteins & Proteomics, 1804, 872-883.
Redaelli,E. Restano-Cassulini,R. Fuentes-Silva,D. Clement,H. Schiavon,E. Zamudio,F.Z. Odell,G. Arcangeli,A. Clare,J.J. Alagon,A. Rodriguez de la Vega,R.C. Possani,L.D. Wanke,E.
2010. Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels Journal of Biological Chemistry, 285, 4130-4142 (Correction vol 285 (17) pp 13314-13314).
Rodriguez de la Vega,R.C. Schwartz,E.F. Possani,L.D.
2010. Mining on scorpion venom biodiversity Toxicon, 56, 1155-1161.
de Roodt,A.R. Coronas,F.I. Lago,N. Gonzalez,M.E. Laskowicz,R.D. Beltramino,J.C. Saavedra,S. Lopez,R.A. Reati,G. Vucharchuk,M.G. Bazan,E. Varni,L. Salomon,O.D. Possani,L.D.
2010. General biochemical and immunological characterization of the venom from the scorpion Tityus trivittatus of Argentina Toxicon, 55, 307-319.
Espino-Solis,G.P. Calderon-Amador,J. Calderon-Aranda,E.S. Licea,A.F. Donis-Maturano,L. Flores-Romo,L. Possani,L.D.
2009. Rational design of synthetic peptides to generate antibodies that recognize in situ CD11c+ putative dendritic cells in horse lymph nodes Veterinary Immunology and Immunopathology, 132, 181-190.
Corzo,G. Prochnicka-Chalufour,A. Garcia,B.I. Possani,L.D. Delepierre,M.
2009. Solution structure of Cn5, a crustacean toxin found in the venom of the scorpions Centruroides noxius and Centruroides suffusus suffusus Biochimica et Biophysica Acta-Proteins and Proteomics, 1794, 1591-1598.
Hernandez-Salgado,K. Estrada,G. Olvera,A. Coronas,F.I. Possani,L.D. Corzo,G.
2009. Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus Immunology Letters, 125, 93-99.
Papp,F. Batista,C.V. Varga,Z. Herceg,M. Roman-Gonzalez,S.A. Gaspar,R. Possani,L.D. Panyi,G.
2009. Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus Toxicon, 54, 379-389.
D'Suze,G. Schwartz,E.F. Garcia,B.I. Sevcik,C. Possani,L.D.
2009. Molecular cloning and nucleotide sequence analysis of genes from a cDNA library of the scorpion Tityus discrepans Biochimie, 91, 1010-1019.
Kauferstein,S. Kendel,Y. Nicke,A. Coronas,F.I. Possani,L.D. Favreau,P. Krizaj,I. Wunder,C. Kauert,G. Mebs,D.
2009. New conopeptides of the D-superfamily selectively inhibiting neuronal nicotinic acetylcholine receptors Toxicon, 54, 295-301.
Schwartz,E.F. Capes,E.M. Diego-Garcia,E. Zamudio,F.Z. Fuentes,O. Possani,L.D. Valdivia,H.H.
2009. Characterization of hadrucalcin, a peptide from Hadrurus gertschi scorpion venom with pharmacological activity on ryanodine receptors British Journal of Pharmacology, 157, 392-403.
Silva,E.C. Camargos,T.S. Maranhao,A.Q. Silva-Pereira,I. Silva,L.P. Possani,L.D. Schwartz,E.F.
2009. Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum Toxicon, 54, 252-261.
Corzo,G. Bernard,C. Clement,H. Villegas,E. Bosmans,F. Tytgat,J. Possani,L.D. Darbon,H. Alagon,A.
2009. Insecticidal peptides from the theraposid spider Brachypelma albiceps: A NMR-based model of Ba2 Biochimica et Biophysica Acta (BBA), 1794, 1190-1196.
Gonzalez-Morales,L. Diego-Garcia,E. Segovia,L. Gutierrez,M.C. Possani,L.D.
2009. Venom from the centipede Scolopendra viridis Say: purification, gene cloning and phylogenetic analysis of a phospholipase A2 Toxicon, 54, 8-15.
Prestipino,G. Corzo,G. Romeo,S. Murgia,A.R. Zanardi,I. Gurrola,G. Possani,L.D.
2009. Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells Toxicology Letters, 187, 1-9.
Espino-Solis,G.P. Riano-Umbarila,L. Becerril,B. Possani,L.D.
2009. Antidotes against venomous animals: State of the art and prospectives Journal of Proteomics, 72, 183-199.
Garcia-Gomez,B.I. Olamendi-Portugal,T.C. Paniagua,J. van der Walt,J. Dyason,K. Possani,L.D.
2009. Heterologous expression of a gene that codes for Pg8, a scorpion toxin of Parabuthus granulatus, capable of generating protecting antibodies in mice Toxicon, 53, 770-778.
Petricevich,V.L. Reynaud,E. Cruz,A.H. Possani,L.D.
2008. Macrophage activation, phagocytosis and intracellular calcium oscillations induced by scorpion toxins from Tityus serrulatus Clinical and Experimental Immunology, 154, 415-423.
Corzo,G. Papp,F. Varga,Z. Barraza,O. Espino-Solis,P.G. Rodriguez de la Vega,R.C. Gaspar,R. Panyi,G. Possani,L.D.
2008. A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus Biochemical Pharmacology, 76, 1142-1154.
Carballar-Lejarazu,R. Rodriguez,M.H. De La Cruz Hernandez-Hernandez,F. Ramos-Castaneda,J. Possani,L.D. Zurita-Ortega,M. Reynaud-Garza,E. Hernandez-Rivas,R. Loukeris,T. Lycett,G. Lanz-Mendoza,H.
2008. Recombinant scorpine: a multifunctional antimicrobial peptide with activity against different pathogens Cellular and Molecular Life Sciences, 65, 3081-3092.
Abdel-Mottaleb,Y. Corzo,G. Martin-Eauclaire,M.F. Satake,H. Ceard,B. Peigneur,S. Nambaru,P. Bougis,P.E. Possani,L.D. Tytgat,J.
2008. A common "hot spot" confers hERG blockade activity to alpha-scorpion toxins affecting K(+) channels Biochemical Pharmacology, 76, 805-815.
Corzo,G. Diego-Garcia,E. Clement,H. Peigneur,S. Odell,G. Tytgat,J. Possani,L.D. Alagon,A.
2008. An insecticidal peptide from the theraposid Brachypelma smithi spider venom reveals common molecular features among spider species from different genera Peptides, 29, 1901-1908.
Schwartz,E.F. Camargos,T.S. Zamudio,F.Z. Silva,L.P. Bloch,C., Jr. Caixeta,F. Schwartz,C.A. Possani,L.D.
2008. Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum Toxicon, 51, 1499-1508.
Olamendi-Portugal,T. Batista,C.V. Restano-Cassulini,R. Pando,V. Villa-Hernandez,O. Zavaleta-Martinez-Vargas,A. Salas-Arruz,M.C. de la Vega RC Becerril,B. Possani,L.D.
2008. Proteomic analysis of the venom from the fish eating coral snake Micrurus surinamensis: Novel toxins, their function and phylogeny Proteomics, 8, 1919-1932.
Restano-Cassulini,R. Olamendi-Portugal,T. Zamudio,F. Becerril,B. Possani,L.D.
2008. Two Novel Ergtoxins, Blockers of K(+)-channels, Purified from the Mexican Scorpion Centruroides elegans elegans Neurochemical Research, 33, 1525-1533.
Romeo,S. Corzo,G. Vasile,A. Satake,H. Prestipino,G. Possani,L.D.
2008. A positive charge at the N-terminal segment of Discrepin increases the blocking effect of K(+) channels responsible for the I(A) currents in cerebellum granular cells Biochim Biophys Acta General Subjects, 1780, 750-755.
Espino-Solis,G.P. Osuna-Quintero,J. Possani,L.D.
2008. Molecular cloning and characterization of the alphaX subunit from CD11c/CD18 horse Veterinary Immunology and Immunopathology, 122, 326-334.
Diego-Garcia,E. Abdel-Mottaleb,Y. Schwartz,E.F. de la Vega RC Tytgat,J. Possani,L.D.
2008. Cytolytic and K(+) channel blocking activities of beta-KTx and scorpine-like peptides purified from scorpion venoms Cellular and Molecular Life Sciences, 65, 187-200.
Petricevich,V.L. Hernandez-Cruz,A. Coronas,F.I. Possani,L.D.
2007. Toxin gamma from Tityus serrulatus scorpion venom plays an essential role in immunomodulation of macrophages. Toxicon, 50, 666-675.
Lopez-Vera,E. Aguilar,M.B. Schiavon,E. Marinzi,C. Ortiz,E. Restano-Cassulini,R. Batista,C.V.F. Possani,L.D. Heimer de la Cotera,E.P. Peri,F. Becerril,B. Wanke,E.
2007. Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors Febs Journal, 274, 3972-3985.
Estrada,G. Garcia,B.I. Schiavon,E. Ortiz,E. Cestele,S. Wanke,E. Possani,L.D. Corzo,G.
2007. Four disulfide-bridged scorpion beta neurotoxin CssII: Heterologous expression and proper folding in vitro Biochimica et Biophysica Acta (BBA), 1770, 1161-1168.
Schwartz,E.F. Diego-Garcia,E. Rodriguez de la Vega,R.C. Possani,L.D.
2007. Transcriptome analysis of the venom gland of the Mexican scorpion Hadrurus gertschi (Arachnida: Scorpiones) BMC Genomics, 8, 119.
Valdez-Cruz,N.A. Segovia,L. Corona,M. Possani,L.D.
2007. Sequence analysis and phylogenetic relationship of genes encoding heterodimeric Phospholipases A2 from the venom of the scorpion Anuroctonus phaiodactylus Gene, 396, 149-158.
Clement,H. Odell,G. Zamudio,F.Z. Redaelli,E. Wanke,E. Alagon,A. Possani,L.D.
2007. Isolation and characterization of a novel toxin from the venom of the spider Grammostola rosea that blocks sodium channels Toxicon, 50, 65-74.
Batista,C.V. Roman-Gonzalez,S.A. Salas-Castillo,S.P. Zamudio,F.Z. Gomez-Lagunas,F. Possani,L.D.
2007. Proteomic analysis of the venom from the scorpion Tityus stigmurus: Biochemical and physiological comparison with other Tityus species Comparative Biochemistry and Physiology, 146, 147-157.
Diego-Garcia,E. Schwartz,E.F. D'Suze,G. Roman-Gonzalez,S.A. Batista,C.V. Garcia,B.I. Rodriguez de la Vega,R.C. Possani,L.D.
2007. Wide phylogenetic distribution of Scorpine and long-chain beta-KTx-like peptides in scorpion venoms: Identification of "orphan" components Peptides, 28, 31-37.
Rodriguez de la Vega,R.C. Possani,L.D.
2007. Novel paradigms on scorpion toxins that affect the activating mechanism of sodium channels Toxicon, 49, 171-180.
Quintero-Hernandez,V. Juarez-Gonzalez,V.R. Ortiz-Leon,M. Sanchez,R. Possani,L.D. Becerril,B.
2007. The change of the scFv into the Fab format improves the stability and in vivo toxin neutralization capacity of recombinant antibodies Molecular Immunology, 44, 1307-1315.
Schwartz,E.F. Schwartz,C.A. Gomez-Lagunas,F. Zamudio,F.Z. Possani,L.D.
2006. HgeTx1, the first K(+)-channel specific toxin characterized from the venom of the scorpion Hadrurus gertschi Soleglad Toxicon, 48, 1046-1053.
Caliskan,F. Garcia,B.I. Coronas,F.I. Batista,C.V. Zamudio,F.Z. Possani,L.D.
2006. Characterization of venom components from the scorpion Androctonus crassicauda of Turkey: Peptides and genes Toxicon, 48, 12-22.
Panyi,G. Possani,L.D. Rodriguez de la Vega,R.C. Gaspar,R. Varga,Z.
2006. K+ Channel Blockers: Novel Tools to Inhibit T Cell Activation Leading to Specific Immunosuppression Current Pharmaceutical Design, 12, 2199-2220.
Batista,C.V. D'Suze,G. Gomez-Lagunas,F. Zamudio,F.Z. Encarnacion,S. Sevcik,C. Possani,L.D.
2006. Proteomic analysis of Tityus discrepans scorpion venom and amino acid sequence of novel toxins Proteomics, 6, 3718-3727.
Schiavon,E. Sacco,T. Restano-Cassulini,R. Gurrola,G. Tempia,F. Possani,L.D. Wanke,E.
2006. Resurgent current and voltage sensor-trapping enhanced activation by a {beta}-scorpion toxin solely in nav1.6 channel: Significance in Mice Purkinje Neurons Journal of Biological Chemistry, 281, 20326-20337.
Mebs,D. Kuch,U. Coronas,F.I. Batista,C.V. Gumprecht,A. Possani,L.D.
2006. Biochemical and biological activities of the venom of the Chinese pitviper Zhaoermia mangshanensis, with the complete amino acid sequence and phylogenetic analysis of a novel Arg49 phospholipase A(2) myotoxin Toxicon, 47, 797-811.
Restano-Cassulini,R. Korolkova,Y.V. Diochot,S. Gurrola,G. Guasti,L. Possani,L. Lazdunski,M. Grishin,E. Arcangeli,A. Wanke,E.
2006. Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS Molecular Pharmacology, 69, 1673-1683.
Prochnicka-Chalufour,A. Corzo,G. Satake,H. Martin-Eauclaire,M.F. Murgia,A.R. Prestipino,G. D'Suze,G. Possani,L.D. Delepierre,M.
2006. Solution Structure of Discrepin, a New K(+)-Channel Blocking Peptide from the alpha-KTx15 Subfamily(,) Biochemistry, 45, 1795-1804.
Abdel-Mottaleb,Y. Coronas,F.V. de Roodt,A.R. Possani,L.D. Tytgat,J.
2006. A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new alpha-KTX subfamily FEBS Letters, 580, 592-596.
Barona,J. Batista,C.V. Zamudio,F.Z. Gomez-Lagunas,F. Wanke,E. Otero,R. Possani,L.D.
2006. Proteomic analysis of the venom and characterization of toxins specific for Na(+)- and K(+)-channels from the Colombian scorpion Tityus pachyurus Biochimica et Biophysica Acta (BBA), 1764, 76-84.
Possani,L.D.
2005. Insecticidal peptide from scorpion venom.Industrial Bioprocessing, 27, 9-10.
Rodriguez de la Vega,R.C. Possani,L.D.
2005. Overview of scorpion toxins specific for Na(+) channels and related peptides: biodiversity, structure-function relationships and evolution Toxicon, 46, 831-844.
Aguilar,M.B. Lopez-Vera,E. Ortiz,E. Becerril,B. Possani,L.D. Olivera,B.M. Heimer de la Cotera,E.P.
2005. A Novel Conotoxin from Conus delessertii with Posttranslationally Modified Lysine Residues Biochemistry, 44, 11130-11136.
Coronas,F.I. Balderas,C. Lopez,L.P. Possani,L.D. Gurrola,G.B.
2005. Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus Journal of the Brazilian Chemical Society, 16, 404-411.
Olamendi-Portugal,T. Somodi,S. Fernandez,J.A. Zamudio,F.Z. Becerril,B. Varga,Z. Panyi,G. Gaspar,R. Possani,L.D.
2005. Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockage Kv1.3 over IKCa1 K(+) channels of T cells Toxicon, 46, 418-429.
Padilla,A. Govezensky,T. Possani,L.D. Larralde,C.
2005. Mortality and antibody responses of mice to three successive episodes of experimental scorpion (Centruroides limpidus limpidus) envenomation and immunological rescue Toxicon, 46, 142-149.
Rodriguez de la Vega,R.C. Possani,L.D.
2005. On the evolution of invertebrate defensins Trends in Genetics, 21, 330-332.
Riano-Umbarila,L. Juarez-Gonzalez,V.R. Olamendi-Portugal,T. Ortiz-Leon,M. Possani,L.D. Becerril,B.
2005. A strategy for the generation of specific human antibodies by directed evolution and phage display Febs Journal, 272, 2591-2601.
Gazarian,K.G. Gazarian,T. Hernandez,R. Possani,L.D.
2005. Immunology of scorpion toxins and perspectives for generation of anti-venom vaccines Vaccine, 23, 3357-3368.
Juarez-Gonzalez,V.R. Riano-Umbarila,L. Quintero-Hernandez,V. Olamendi-Portugal,T. Ortiz-Leon,M. Ortiz,E. Possani,L.D. Becerril,B.
2005. Directed Evolution, Phage Display and Combination of Evolved Mutants: A Strategy to Recover the Neutralization Properties of the scFv Version of BCF2 a Neutralizing Monoclonal Antibody Specific to Scorpion Toxin Cn2 Journal of Molecular Biology, 346, 1287-1297.
Diego-Garcia,E. Batista,C.V. Garcia-Gomez,B.I. Lucas,S. Candido,D.M. Gomez-Lagunas,F. Possani,L.D.
2005. The Brazilian scorpion Tityus costatus Karsch: genes, peptides and function Toxicon, 45, 273-283.
Bagdaany,M. Batista,C.V. Valdez-Cruz,N.A. Somodi,S. Rodriguez de la Vega,R.C. Licea,A.F. Varga,Z. Gaspar,R. Possani,L.D. Panyi,G.
2005. Anuroctoxin, a new scorpion toxin of the {alpha}-KTx 6 subfamily is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes Molecular Pharmacology, 67, 1034-1044.
Valdez-Cruz,N.A. Batista,C.V. Zamudio,F.Z. Bosmans,F. Tytgat,J. Possani,L.D.
2004. Phaiodotoxin, a novel structural class of insect-toxin isolated from the venom of the Mexican scorpion Anuroctonus phaiodactylus European Journal of Biochemistry, 271, 4753-4761.
D'Suze,G. Batista,C.V. Frau,A. Murgia,A.R. Zamudio,F.Z. Sevcik,C. Possani,L.D. Prestipino,G.
2004. Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K(+)-channels (I(A) currents) of cerebellum granular cells Archives of Biochemistry and Biophysics, 430, 256-263.
Valdez-Cruz,N.A. Davila,S. Licea,A. Corona,M. Zamudio,F.Z. Garcia-Valdes,J. Boyer,L. Possani,L.D.
2004. Biochemical, genetic and physiological characterization of venom components from two species of scorpions: Centruroides exilicauda Wood and Centruroides sculpturatus Ewing Biochimie, 86, 387-396.
Frenal,K. Xu,C.Q. Wolff,N. Wecker,K. Gurrola,G.B. Zhu,S.Y. Chi,C.W. Possani,L.D. Tytgat,J. Delepierre,M.
2004. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels Proteins, 56, 367-375.
Rodriguez de la Vega,R.C. Possani,L.D.
2004. Current views on scorpion toxins specific for K(+)-channels Toxicon, 43, 865-875.
Rodriguez de la Vega,R.C. Garcia,B.I. D'Ambrosio,C. Diego-Garcia,E. Scaloni,A. Possani,L.D.
2004. Antimicrobial peptide induction in the haemolymph of the Mexican scorpion Centruroides limpidus limpidus in response to septic injury Cellular and Molecular Life Sciences, 61, 1507-1519.
Rio-Portilla,F. Hernandez-Marin,E. Pimienta,G. Coronas,F.V. Zamudio,F.Z. Rodriguez de la Vega,R.C. Wanke,E. Possani,L.D.
2004. NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical beta-toxin sequence but with alpha-like physiological activity European Journal of Biochemistry, 271, 2504-2516.
Murgia,A.R. Batista,C.V. Prestipino,G. Possani,L.D.
2004. Amino acid sequence and function of a new alpha-toxin from the Amazonian scorpion Tityus cambridgei Toxicon, 43, 737-740.
Valdez-Cruz,N.A. Batista,C.V. Possani,L.D.
2004. Phaiodactylipin, a glycosylated heterodimeric phospholipase A from the venom of the scorpion Anuroctonus phaiodactylus European Journal of Biochemistry, 271, 1453-1464.
Zhu,X. Zamudio,F.Z. Olbinski,B.A. Possani,L.D. Valdivia,H.H.
2004. Activation of skeletal ryanodine receptors by two novel scorpion toxins from buthotus judaicus Journal of Biological Chemistry, 279, 26588-26596.
Montero-Solis,C. Gonzalez-Ceron,L. Rodriguez,M.H. Cirerol,B.E. Zamudio,F. Possanni,L.D. James,A.A. De La Cruz Hernandez-Hernandez,F.
2004. Identification and characterization of gp65, a salivary-gland-specific molecule expressed in the malaria vector Anopheles albimanus Insect Molecular Biology, 13, 155-164.
Selisko,B. Cosio,G. Garcia,C. Becerril,B. Possani,L.D. Horjales,E.
2004. Bacterial expression, purification and functional characterization of a recombinant chimeric Fab derived from murine mAb BCF2 that neutralizes the venom of the scorpion Centruroides noxius hoffmann Toxicon, 43, 43-51.
D'Suze,G. Sevcik,C. Corona,M. Zamudio,F.Z. Batista,C.V. Coronas,F.I. Possani,L.D.
2004. Ardiscretin a novel arthropod-selective toxin from Tityus discrepans scorpion venom Toxicon, 43, 263-272.
Batista,C.V. Del Pozo,L. Zamudio,F.Z. Contreras,S. Becerril,B. Wanke,E. Possani,L.D.
2004. Proteomics of the venom from the Amazonian scorpion Tityus cambridgei and the role of prolines on mass spectrometry analysis of toxins Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 803, 55-66.
Gomez-Lagunas,F. Batista,C.V. Olamendi-Portugal,T. Ramirez-Dominguez,M.E. Possani,L.D.
2004. Inhibition of the collapse of the shaker k+ conductance by specific scorpion toxins Journal of General Physiology, 123, 265-279.
Pascual,I. Gil-Parrado,S. Cisneros,M. Joseph-Bravo,P. Diaz,J. Possani,L.D. Charli,J.L. Chavez,M.
2004. Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. In vivo effects in rodent brain International Journal of Biochemistry and Cell Biology, 36, 138-152.
Shalabi,A. Zamudio,F. Wu,X. Scaloni,A. Possani,L. Villereal,M.L.
2004. Tetrapandins, a new class of scorpion toxins that specifically inhibit store-operated calcium entry in HEK-293 cells Journal of Biological Chemistry, 279, 1040-1049.
Huys,I. Olamendi-Portugal,T. Garcia-Gomez,B.I. Vandenberghe,I. Van Beeumen,J. Dyason,K. Clynen,E. Zhu,S. van der Walt,J. Possani,L. Tytgat,J.
2004. A subfamily of acidic alpha -K+ toxins Journal of Biological Chemistry, 279, 2781-2789.
Xu,C.Q. Zhu,S.Y. Chi,C.W. Tytgat,J. Possani,L.D. Rodriguez de la Vega,R.C.
2003. Turret and pore block of K+ channels: What is the difference? (multiple letters) Trends in Pharmacological Sciences, 24, 446-449.
Possani,L.D. Rodriguez de la Vega,R.C.
2003. Response to Xu et al.: Hypothesis-driven science paves the way for new discoveries Trends in Pharmacological Sciences, 24, 448-449.
Guijarro,J.I. M'Barek,S. Gomez-Lagunas,F. Garnier,D. Rochat,H. Sabatier,J.M. Possani,L.D. Delepierre,M.
2003. Solution structure of Pi4, a short four-disulfide-bridged scorpion toxin specific of potassium channels Protein Science, 12, 1844-1854.
Padilla,A. Govezensky,T. Possani,L.D. Larralde,C.
2003. Experimental envenoming of mice with venom from the scorpion Centruroides limpidus limpidus: differences in mortality and symptoms with and without antibody therapy relating to differences in age, sex and strain of mouse Toxicon, 41, 959-965.
Coronas,F.V. Stankiewicz,M. Batista,C.V. Giraud,S. Alam,J.M. Possani,L.D. Mebs,D. Pelhate,M.
2003. Primary structure and electrophysiological characterization of two almost identical isoforms of toxin from Isometrus vittatus (family: Buthidae) scorpion venom Toxicon, 41, 989-997.
Gutierrez,M.C. Abarca,C. Possani,L.D.
2003. A toxic fraction from scolopendra venom increases the basal release of neurotransmitters in the ventral ganglia of crustaceans Comparative Biochemistry and Physiology, 135, 205-214.
Corona,M. Coronas,F.V. Merino,E. Becerril,B. Gutierrez,R. Rebolledo-Antunez,S. Garcia,D.E. Possani,L.D.
2003. A novel class of peptide found in scorpion venom with neurodepressant effects in peripheral and central nervous system of the rat Biochimica et Biophysica Acta-Proteins and Proteomics, 1649, 58-67.
Rodriguez de la Vega,R.C. Merino,E. Becerril,B. Possani,L.D.
2003. Novel interactions between K(+) channels and scorpion toxins Trends in Pharmacological Sciences, 24, 222-227.
Gazarian,T.G. Selisko,B. Gurrola,G.B. Possani,L.D. Gazarian,K.G.
2003. Potential of Peptides Selected from Random Phage-Displayed Libraries to Mimic Conformational Epitopes: A Study on Scorpion Toxin Cn2 and the Neutralizing Monoclonal Antibody BCF2 Combinatorial Chemistry & High Throughput Screening, 6, 119-132.
Garcia,C. Calderon-Aranda,E.S. Anguiano,G.A. Becerril,B. Possani,L.D.
2003. Analysis of the immune response induced by a scorpion venom sub-fraction, a pure peptide and a recombinant peptide, against toxin Cn2 of Centruroides noxius Hoffmann Toxicon, 41, 417-427.
Coronas,F.V. de Roodt,A.R. Portugal,T.O. Zamudio,F.Z. Batista,C.V. Gomez-Lagunas,F. Possani,L.D.
2003. Disulfide bridges and blockage of Shaker B K(+)-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus Toxicon, 41, 173-179.
Lopez-Gonzalez,I. Olamendi-Portugal,T. de la Vega-Beltran,J.L. van der Walt,J. Dyason,K. Possani,L.D. Felix,R. Darszon,A.
2003. Scorpion toxins that block T-type Ca(2+) channels in spermatogenic cells inhibit the sperm acrosome reaction Biochemical and Biophysical Research Communications, 300, 408-414.
Corzo,G. Villegas,E. Gomez-Lagunas,F. Possani,L.D. Belokoneva,O.S. Nakajima,T.
2002. Oxyopinins, large amphipathic peptides isolated from the venom of the wolf spider Oxyopes kitabensis with cytolytic properties and positive insecticidal cooperativity with spider neurotoxins Journal of Biological Chemistry, 277, 23627-23637.
Angulo,Y. Olamendi-Portugal,T. Alape-Giron,A. Possani,L.D. Lomonte,B.
2002. Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue International Journal of Biochemistry and Cell Biology, 34, 1268-1278.
Vacher,H. Alami,M. Crest,M. Possani,L.D. Bougis,P.E. Martin-Eauclaire,M.F.
2002. Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus European Journal of Biochemistry, 269, 6037-6041.
Olamendi-Portugal,T. Garcia,B.I. Lopez-Gonzalez,I. van der Walt,J. Dyason,K. Ulens,C. Tytgat,J. Felix,R. Darszon,A. Possani,L.D.
2002. Two new scorpion toxins that target voltage-gated Ca(2+) and Na(+) channels Biochemical and Biophysical Research Communications, 299, 562-568.
Corona,M. Gurrola,G.B. Merino,E. Cassulini,R.R. Valdez-Cruz,N.A. Garcia,B. Ramirez-Dominguez,M.E. Coronas,F.I. Zamudio,F.Z. Wanke,E. Possani,L.D.
2002. A large number of novel Ergtoxin-like genes and ERG K(+)-channels blocking peptides from scorpions of the genus Centruroides FEBS Letters, 532, 121-126.
Batista,C.V. Gomez-Lagunas,F. Rodriguez de la Vega,R.C. Hajdu,P. Panyi,G. Gaspar,R. Possani,L.D.
2002. Two novel toxins from the Amazonian scorpion Tityus cambridgei that block Kv1.3 and Shaker B K(+)-channels with distinctly different affinities Biochimica et Biophysica Acta-Proteins and Proteomics, 1601, 123-131.
Possani,L.D. Corona,M. Zurita,M. Rodriguez,M.H.
2002. From Noxiustoxin to Scorpine and Possible Transgenic Mosquitoes Resistant to Malaria Archives of Medical Research, 33, 398-404.
Pardo-Lopez,L. Zhang,M. Liu,J. Jiang,M. Possani,L.D. Tseng,G.N.
2002. Mapping the binding site of a human ether-a-go-go-related gene-specific peptide toxin (ErgTx) to the channel's outer vestibule Journal of Biological Chemistry, 277, 16403-16411.
Lecchi,M. Redaelli,E. Rosati,B. Gurrola,G. Florio,T. Crociani,O. Curia,G. Cassulini,R.R. Masi,A. Arcangeli,A. Olivotto,M. Schettini,G. Possani,L.D. Wanke,E.
2002. Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release Journal of Neuroscience, 22, 3414-3425.
Ramirez-Dominguez,M.E. Olamendi-Portugal,T. Garcia,U. Garcia,C. Arechiga,H. Possani,L.D.
2002. Cn11, the first example of a scorpion toxin that is a true blocker of Na(+) currents in crayfish neurons Journal of Experimental Biology, 205, 869-876.
Batista,C.V. Zamudio,F.Z. Lucas,S. Fox,J.W. Frau,A. Prestipino,G. Possani,L.D.
2002. Scorpion toxins from Tityus cambridgei that affect Na(+)-channels Toxicon, 40, 557-562.
Pardo-Lopez,L. Garcia-Valdes,J. Gurrola,G.B. Robertson,G.A. Possani,L.D.
2002. Mapping the receptor site for ergtoxin, a specific blocker of ERG channels FEBS Letters, 510, 45-49.
Goudet,C. Ferrer,T. Galan,L. Artiles,A. Batista,C.F. Possani,L.D. Alvarez,J. Aneiros,A. Tytgat,J.
2001. Characterization of two Bunodosoma granulifera toxins active on cardiac sodium channels British Journal of Pharmacology, 134, 1195-1206.
Corona,M. Valdez-Cruz,N.A. Merino,E. Zurita,M. Possani,L.D.
2001. Genes and peptides from the scorpion Centruroides sculpturatus Ewing, that recognize Na(+)-channels Toxicon, 39, 1893-1898.
Garcia-Valdes,J. Zamudio,F.Z. Toro,L. Possan,L.D.
2001. Slotoxin, alphaKTx1.11, a new scorpion peptide blocker of MaxiK channels that differentiates between alpha and alpha+beta (beta1 or beta4) complexes FEBS Letters, 505, 369-373. Correction 507 (1) 122.
Rocchetti,M. Besana,A. Gurrola,G.B. Possani,L.D. Zaza,A.
2001. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential Journal of Physiology, 534, 721-732.
Peter,M.J. Varga,Z. Hajdu,P. Gaspar,R. Damjanovich,S. Horjales,E. Possani,L.D. Panyi,G.
2001. Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24 Journal of Membrane Biology, 179, 13-25.
Frau,A. Pisciotta,M. Gurrola,G.B. Possani,L.D. Prestipino,G.
2001. Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells European Biophysics Journal, 29, 569-573.
Nishigaki,T. Zamudio,F.Z. Possani,L.D. Darszon,A.
2001. Time-Resolved Sperm Responses to an Egg Peptide Measured by Stopped-Flow Fluorometry Biochemical and Biophysical Research Communications, 284, 531-535.
Possani,L.D.
2000. Antivenom for scorpion sting Lancet, 355, 67.
Batista,C.V. Gomez-Lagunas,F. Lucas,S. Possani,L.D.
2000. Tc1, from Tityus cambridgei, is the first member of a new subfamily of scorpion toxin that blocks K(+)-channels FEBS Letters, 486, 117-120.
Angulo,Y. Olamendi-Portugal,T. Possani,L.D. Lomonte,B.
2000. Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue International Journal of Biochemistry and Cell Biology, 32, 63-71.
Conde,R. Zamudio,F.Z. Rodriguez,M.H. Possani,L.D.
2000. Scorpine, an anti-malaria and anti-bacterial agent purified from scorpion venom FEBS Letters, 471, 165-168.
Torres-Larios,A. Gurrola,G.B. Zamudio,F.Z. Possani,L.D.
2000. Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus European Journal of Biochemistry, 267, 5023-5031.
Pisciotta,M. Coronas,F.I. Bloch,C. Prestipino,G. Possani,L.D.
2000. Fast K(+) currents from cerebellum granular cells are completely blocked by a peptide purified from Androctonus australis Garzoni scorpion venom Biochimica Et Biophysica Acta-Biomembranes, 1468, 203-212.
Bottiglieri,C. Ferrara,L. Corona,M. Gurrola,G.B. Batista,C. Wanke,E. Possani,L.D.
2000. Disulfide bridges of ergtoxin, a member of a new sub-family of peptide blockers of the ether-a-go-go-related K+ channel FEBS Letters, 479, 156-157 Correction 481 (3) 308.
Peter,M.J. Hajdu,P. Varga,Z. Damjanovich,S. Possani,L.D. Panyi,G. Gaspar,R.
2000. Blockage of human T lymphocyte Kv1.3 channels by Pi1, a novel class of scorpion toxin Biochemical and Biophysical Research Communications, 278, 34-37.
Possani,L.D. Merino,E. Corona,M. Bolivar,F. Becerril,B.
2000. Peptides and genes coding for scorpion toxins that affect ion-channels Biochimie, 82, 861-868.
Possani,L.D. Selisko,B. Gurrola,G.B.
1999. Structure and function of scorpion toxins affecting K+-channels Perspectives In Drug Discovery And Design, 16, 15-40.
Ottolia,M. Babini,E. Gazzotti,P. Possani,L.D. Prestipino,G.
1999. Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum Brain Research, 815, 410-413.
Altamirano,M.M. Garcia,C. Possani,L.D. Fersht,A.R.
1999. Oxidative refolding chromatography: folding of the scorpion toxin Cn5 Nature Biotechnology, 17, 187-191.
Yamamoto,H. Sejbal,J. York,E. Stewart,J.M. Possani,L.D. Kotovych,G.
1999. 3.0.CO;2-Y> An nmr conformational analysis of a synthetic peptide Cn2(1-15)NH2-S-S-acetyl-Cn2(52-66)NH2 from the New World Centruroides noxius 2 (Cn2) scorpion toxin: comparison of the structure with those of the Centruroides scorpion toxins Biopolymers, 49, 277-286.
Pintar,A. Possani,L.D. Delepierre,M.
1999. Solution structure of toxin 2 from centruroides noxius Hoffmann, a beta-scorpion neurotoxin acting on sodium channels Journal of Molecular Biology, 287, 359-367.
Calderon-Aranda,E.S. Riviere,G. Choumet,V. Possani,L.D. Bon,C.
1999. Pharmacokinetics of the toxic fraction of Centruroides limpidus limpidus venom in experimentally envenomed rabbits and effects of immunotherapy with specific F(ab')2 Toxicon, 37, 771-782.
Gurrola,G.B. Rosati,B. Rocchetti,M. Pimienta,G. Zaza,A. Arcangeli,A. Olivotto,M. Possani,L.D. Wanke,E.
1999. A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom FASEB Journal, 13, 953-962.
Selisko,B. Licea,A.F. Becerril,B. Zamudio,F. Possani,L.D. Horjales,E.
1999. 3.0.CO;2-S> Antibody BCF2 against scorpion toxin Cn2 from Centuroides noxius Hoffmann: primary structure and three-dimensional model as free Fv fragment and complexed with its antigen Proteins, 37, 130-143.
D'Suze,G. Zamudio,F. Gomez-Lagunas,F. Possani,L.D.
1999. A novel K+ channel blocking toxin from Tityus discrepans scorpion venom FEBS Letters, 456, 146-148.
Batista,C.V. da Silva,L.R. Sebben,A. Scaloni,A. Ferrara,L. Paiva,G.R. Olamendi-Portugal,T. Possani,L.D. Bloch,C.
1999. Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta Peptides, 20, 679-686.
Possani,L.D. Becerril,B. Delepierre,M. Tytgat,J.
1999. Scorpion toxins specific for Na+-channels European Journal of Biochemistry, 264, 287-300.
Calderon-Aranda,E.S. Selisko,B. York,E.J. Gurrola,G.B. Stewart,J.M. Possani,L.D.
1999. Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides European Journal of Biochemistry, 264, 746-755.
Tytgat,J. Chandy,K.G. Garcia,M.L. Gutman,G.A. Martin-Eauclaire,M.F. van der Walt,J.J. Possani,L.D.
1999. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies Trends in Pharmacological Sciences, 20, 444-447.
Conde,R. Zamudio,F.Z. Becerril,B. Possani,L.D.
1999. Phospholipin, a novel heterodimeric phospholipase A2 from Pandinus imperator scp6pion venom FEBS Letters, 460, 447-450.
Delepierre,M. Prochnicka-Chalufour,A. Boisbouvier,J. Possani,L.D.
1999. Pi7, an orphan peptide from the scorpion Pandinus imperator: a 1H-NMR analysis using a nano-NMR Probe Biochemistry, 38, 16756-16765.
Licea,A.F. Gutierrez,M.C. Esparza,J. Estrada-Parra,S. Estrada,G.I. Quesada-Pascual,F. Possani,L.D.
1998. Enhancement of the immunogenicity of Mycobacterium leprae peptides by means of polymerization.Asia-Pacific Journal Of Molecular Biology And Biotechnology, 6, 89-95.
Valdivia,H.H. Possani,L.D.
1998. Peptide toxins as probes of ryanodine receptor structure and function Trends in Cardiovascular Medicine, 8, 111-118.
Possani,L.D. Zurita,M. Delepierre,M. Hernandez,F.H. Rodriguez,M.H.
1998. From noxiustoxin to Shiva-3, a peptide toxic to the sporogonic development of Plasmodium berghei Toxicon, 36, 1683-1692.
Pisciotta,M. Ottolia,M. Possani,L.D. Prestipino,G.
1998. A novel toxin form the scorpion Androctonus australis blocks Shaker K+ channels expressed in Xenopus oocytes Biochemical and Biophysical Research Communications, 242, 287-291.
Pisciotta,M. Coronas,F.I. Possani,L.D. Prestipino,G.
1998. The Androctonus australis garzoni scorpion venom contains toxins that selectively affect voltage-dependent K(+)-channels in cerebellum granular cells European Biophysics Journal, 27, 69-73.
Peter,M.J. Varga,Z. Panyi,G. Bene,L. Damjanovich,S. Pieri,C. Possani,L.D. Gaspar,R.
1998. Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytes Biochemical and Biophysical Research Communications, 242, 621-625.
Martinez,F. Munoz-Garay,C. Gurrola,G. Darszon,A. Possani,L.D. Becerril,B.
1998. Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels FEBS Letters, 429, 381-384.
Selisko,B. Garcia,C. Becerril,B. Gomez-Lagunas,F. Garay,C. Possani,L.D.
1998. Cobatoxins 1 and 2 from Centruroides noxius Hoffmann constitute a subfamily of potassium-channel-blocking scorpion toxins European Journal of Biochemistry, 254, 468-479.
Delepierre,M. Prochnicka-Chalufour,A. Possani,L.D.
1998. 1H NMR structural analysis of novel potassium blocking toxins using a nano-NMR probe Toxicon, 36, 1599-1608.
Boisbouvier,J. Prochnicka-Chalufour,A. Nieto,A.R. Torres,J.A. Nanard,N. Rodriguez,M.H. Possani,L.D. Delepierre,M.
1998. Structural information on a cecropin-like synthetic peptide, Shiva-3 toxic to the sporogonic development of Plasmodium berghei European Journal of Biochemistry, 257, 263-273.
Tytgat,J. Debont,T. Rostoll,K. Muller,G.J. Verdonck,F. Daenens,P. van der Walt,J.J. Possani,L.D.
1998. Purification and partial characterization of a 'short' insectotoxin-like peptide from the venom of the scorpion Parabuthus schlechteri FEBS Letters, 441, 387-391.
Olamendi-Portugal,T. Gomez-Lagunas,F.G. Gurrola,G.B. Possani,L.D.
1998. Two similar peptides from the venom of the scorpion Pandinus imperator, one highly effective blocker and the other inactive on K+ channels Toxicon, 36, 759-770.
Gomez-Lagunas,F. Olamendi-Portugal,T. Possani,L.D.
1997. Block of ShakerB K+ channels by Pi1, a novel class of scorpion toxin FEBS Letters, 400, 197-200.
Garcia,C. Becerril,B. Selisko,B. Delepierre,M. Possani,L.D.
1997. Isolation, characterization and comparison of a novel crustacean toxin with a mammalian toxin from the venom of the scorpion Centruroides noxius Hoffmann Comparative Biochemistry and Physiology, 116, 315-322.
Delepierre,M. Prochnicka-Chalufour,A. Possani,L.D.
1997. A novel potassium channel blocking toxin from the scorpion Pandinus imperator: A 1H NMR analysis using a nano-NMR probe Biochemistry, 36, 2649-2658.
Zamudio,F.Z. Gurrola,G.B. Arevalo,C. Sreekumar,R. Walker,J.W. Valdivia,H.H. Possani,L.D.
1997. Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors FEBS Letters, 405, 385-389.
Zamudio,F.Z. Conde,R. Arevalo,C. Becerril,B. Martin,B.M. Valdivia,H.H. Possani,L.D.
1997. The mechanism of inhibition of ryanodine receptor channels by imperatoxin I, a heterodimeric protein from the scorpion Pandinus imperator Journal of Biological Chemistry, 272, 11886-11894.
Becerril,B. Marangoni,S. Possani,L.D.
1997. Toxins and genes isolated from scorpions of the genus Tityus Toxicon, 35, 821-835.
Ben Khalifa,R. Stankiewicz,M. Pelhate,M. Serrano-Hernandez,S.E. Possani,L.D. Hinkel,H. Mebs,D.
1997. Action of babycurus-toxin 1 from the east African scorpion Babycurus centrurimorphus on the isolated cockroach giant axon Toxicon, 35, 1069-1080.
Higareda,A.E. Possani,L.D. Ramirez,O.T.
1997. 3.0.CO;2-H> The use of culture redox potential and oxygen uptake rate for assessing glucose and glutamine depletion in hybridoma cultures Biotechnology and Bioengineering, 56, 555-563.
Corona,M. Zurita,M. Possani,L.D. Becerril,B.
1996. Cloning and characterization of the genomic region encoding toxin IV-5 from the scorpion Tityus serrulatus Lutz and Mello Toxicon, 34, 251-256.
Dehesa-Davila,M. Ramirez,A.N. Zamudio,F.Z. Gurrola-Briones,G. Lievano,A. Darszon,A. Possani,L.D.
1996. Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius Comparative Biochemistry and Physiology, 113, 331-339.
Becerril,B. Corona,M. Coronas,F.I. Zamudio,F. Calderon-Aranda,E.S. Fletcher,P.L. Martin,B.M. Possani,L.D.
1996. Toxic peptides and genes encoding toxin gamma of the Brazilian scorpions Tityus bahiensis and Tityus stigmurus Biochemical Journal, 313, 753-760.
Vaca,L. Licea,A. Possani,L.D.
1996. Modulation of cell membrane potential in cultured vascular endothelium American Journal of Physiology, 270, C819-C824.
Olamendi-Portugal,T. Gomez-Lagunas,F. Gurrola,G.B. Possani,L.D.
1996. A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator Biochemical Journal, 315, 977-981.
D'Suze,G. Corona,F. Possani,L.D. Sevcik,C.
1996. High performance liquid chromatography purification and amino acid sequence of toxins from the muscarinic fraction of Tityus discrepans scorpion venom Toxicon, 34, 591-598.
Nobile,M. Noceti,F. Prestipino,G. Possani,L.D.
1996. Helothermine, a lizard venom toxin, inhibits calcium current in cerebellar granules Experimental Brain Research, 110, 15-20.
Zamudio,F. Wolf,K.M. Martin,B.M. Possani,L.D. Chiappinelli,V.A.
1996. Two novel alpha-neurotoxins isolated from the taipan snake, Oxyuranus scutellatus, exhibit reduced affinity for nicotinic acetylcholine receptors in brain and skeletal muscle Biochemistry, 35, 7910-7916.
Gomez-Lagunas,F. Olamendi-Portugal,T. Zamudio,F.Z. Possani,L.D.
1996. Two novel toxins from the venom of the scorpion Pandinus imperator show that the N-terminal amino acid sequence is important for their affinities towards Shaker B K+ channels Journal of Membrane Biology, 152, 49-56.
Licea,A.F. Becerril,B. Possani,L.D.
1996. Fab fragments of the monoclonal antibody BCF2 are capable of neutralizing the whole soluble venom from the scorpion Centruroides noxius Hoffmann Toxicon, 34, 843-847.
Nieto,A.R. Gurrola,G.B. Vaca,L. Possani,L.D.
1996. Noxiustoxin 2, a novel K+ channel blocking peptide from the venom of the scorpion Centruroides noxius Hoffmann Toxicon, 34, 913-922.
Martinez,F. Becerril,B. Gurrola,G.B. Martin,B.M. Possani,L.D.
1996. Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius Toxicon, 34, 1413-1419.
Selisko,B. Garcia,C. Becerril,B. Delepierre,M. Possani,L.D.
1996. An insect-specific toxin from Centruroides noxius Hoffmann. cDNA, primary structure, three-dimensional model and electrostatic surface potentials in comparison with other toxin variants European Journal of Biochemistry, 242, 235-242.
Possani,L.D.
1995. Monoclonal antibodies BNTX14, anti-noxiustoxin Hybridoma, 14, 302.
Possani,L.D.
1995. Monoclonal antibodies BNTX21, anti-noxiustoxin Hybridoma, 14, 305.
Possani,L.D.
1995. Monoclonal antibodies BNTX16, anti-noxiustoxin Hybridoma, 14, 303.
Possani,L.D.
1995. Monoclonal antibodies BNTX4, anti-noxiustoxin Hybridoma, 14, 300.
Possani,L.D.
1995. Monoclonal antibodies BNTX18, anti-noxiustoxin Hybridoma, 14, 304.
Possani,L.D.
1995. Monoclonal antibodies BNTX12, anti-noxiustoxin Hybridoma, 14, 301.
Morrissette,J. Kratzschmar,J. Haendler,B. Elhayek,R. Mochca-Morales,J. Martin,B.M. Patel,J.R. Moss,R.L. Schleuning,W.D. Coronado,R. Possani,L.D.
1995. Primary Structure and Properties of Helothermine, A Peptide Toxin That Blocks Ryanodine Receptors Biophysical Journal, 68, 2280-2288.
Herion,P. Gurrola-Briones,G. Sanchez,M.D.R. Saavedra,R. Possani,L.D.
1995. Monoclonal antibodies against noxiustoxin Hybridoma, 14, 247-251.
Rodriguez,M.C. Zamudio,F. Torres,J.A. Gonzalez-Ceron,L. Possani,L.D. Rodriguez,M.H.
1995. Effect of a cecropin-like synthetic peptide (Shiva-3) on the sporogonic development of Plasmodium berghei Experimental Parasitology, 80, 596-604.
Drakopoulou,E. Cotton,J. Virelizier,H. Bernardi,E. Schoofs,A.R. Partiseti,M. Choquet,D. Gurrola,G. Possani,L.D. Vita,C.
1995. Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels Biochemical and Biophysical Research Communications, 213, 901-907.
Gaspar,R. Bene,L. Damjanovich,S. Munoz-Garay,C. Calderon-Aranda,E.S. Possani,L.D.
1995. Beta-scorpion toxin 2 from Centruroides noxius blocks voltage-gated K+ channels in human lymphocytes Biochemical and Biophysical Research Communications, 213, 419-423.
Trequattrini,C. Zamudio,F.Z. Petris,A. Prestipino,G. Possani,L.D. Franciolini,F.
1995. Tityus bahiensis toxin IV-5b selectively affects Na channel inactivation in chick dorsal root ganglion neurons Comparative Biochemistry and Physiology -- Part A: Physiology, 112, 21-28.
Calderon-Aranda,E.S. Olamendi-Portugal,T. Possani,L.D.
1995. The use of synthetic peptides can be a misleading approach to generate vaccines against scorpion toxins Vaccine, 13, 1198-1206.
Vazquez,A. Tapia,J.V. Eliason,W.K. Martin,B.M. Lebreton,F. Delepierre,M. Possani,L.D. Becerril,B.
1995. Cloning and characterization of the cDNAs encoding Na+ channel-specific toxins 1 and 2 of the scorpion Centruroides noxius Hoffmann Toxicon, 33, 1161-1170.
Noceti,F. Ramirez,A.N. Possani,L.D. Prestipino,G.
1995. Characterization of a voltage-dependent potassium channel in squid Schwann cells reconstituted in planar lipid bilayers Glia, 15, 33-42.
Gurrola,G.B. Possani,L.D.
1995. Structural and functional features of noxiustoxin: a K+ channel blocker.Biochemistry and Molecular Biology International, 37, 527-535.
Noeske-Jungblut,C. Haendler,B. Donner,P. Alagon,A. Possani,L. Schleuning,W.D.
1995. Triabin, a highly potent exosite inhibitor of thrombin Journal of Biological Chemistry, 270, 28629-28634.
Dauplais,M. Gilquin,B. Possani,L.D. Gurrola-Briones,G. Roumestand,C. Menez,A.
1995. Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins Biochemistry, 34, 16563-16573.
Becerril,B. Corona,M. Garcia,C. Bolivar,F. Possani,L.D.
1995. Cloning of genes encoding scorpion toxins: An interpretative review Journal Of Toxicology-Toxin Reviews, 14, 339-357.
Gutierrez,M.C. ESTRADA,I.C.E. Estrada-Parra,S. Quesada-Pascual,F. Licea,A.F. Possani,L.D.
1994. The imunogenetic activity of synthetic peptides corresponding to M. Leprae protein sequences.Asia-Pacific Journal Of Molecular Biology And Biotechnology, 2, 143-150.
Gurrola,G.B. Moreno-Hagelsieb,G. Zamudio,F.Z. Garcia,M. Soberon,X. Possani,L.D.
1994. The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus FEBS Letters, 347, 59-62.
Higareda,A.E. Possani,L.D. Ramirez,O.T.
1994. Metabolic and kinetic studies of hybridomas in exponentially fed-batch cultures using T-flasks Cytotechnology, 15, 73-86.
Noeske-Jungblut,C. Kratzschmar,J. Haendler,B. Alagon,A. Possani,L. Verhallen,P. Donner,P. Schleuning,W.D.
1994. An inhibitor of collagen-induced platelet aggregation from the saliva of Triatoma pallidipennis Journal of Biological Chemistry, 269, 5050-5053.
Ramirez,A.N. Martin,B.M. Gurrola,G.B. Possani,L.D.
1994. Isolation and characterization of a novel toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch Toxicon, 32, 479-490.
Nobile,M. Magnelli,V. Lagostena,L. Mochca-Morales,J. Possani,L.D. Prestipino,G.
1994. The toxin helothermine affects potassium currents in newborn rat cerebellar granule cells Journal of Membrane Biology, 139, 49-55.
Sacile,R. Ruggiero,C. Ballestrero,R. Possani,L.D. Prestipino,G. Rauch,G.
1994. Secondary structure of noxiustoxin and charybdotoxin from hydropathy power spectra Biochemical and Biophysical Research Communications, 201, 186-193.
Dehesa-Davila,M. Possani,L.D.
1994. Scorpionism and serotherapy in Mexico Toxicon, 32, 1015-1018.
Lebreton,F. Delepierre,M. Ramirez,A.N. Balderas,C. Possani,L.D.
1994. Primary and NMR three-dimensional structure determination of a novel crustacean toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch Biochemistry, 33, 11135-11149.
Fletcher,M.D. Possani,L.D. Fletcher,P.L.
1994. Morphological studies by light and electron microscopy of pancreatic acinar cells under the effect of Tityus serrulatus venom Cell and Tissue Research, 278, 255-264.
Martin,B.M. Ramirez,A.N. Gurrola,G.B. Nobile,M. Prestipino,G. Possani,L.D.
1994. Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch Biochemical Journal, 304, 51-56.
Valdivia,H.H. Martin,B.M. Ramirez,A.N. Fletcher,P.L. Possani,L.D.
1994. Isolation and pharmacological characterization of four novel Na+ channel-blocking toxins from the scorpion Centruroides noxius Hoffmann Journal of Biochemistry, 116, 1383-1391.
Dehesa-Davila,M. Martin,B.M. Nobile,M. Prestipino,G. Possani,L.D.
1994. Isolation of a toxin from Centruroides infamatus infamatus Koch scorpion venom that modifies Na+ permeability on chick dorsal root ganglion cells Toxicon, 32, 1487-1493.
Calderon-Aranda,E.S. Hozbor,D. Possani,L.D.
1993. Neutralizing capacity of murine sera induced by different antigens of scorpion venom Toxicon, 31, 327-337.
Vazquez,A. Becerril,B. Martin,B.M. Zamudio,F. Bolivar,F. Possani,L.D.
1993. Primary structure determination and cloning of the cDNA encoding toxin 4 of the scorpion Centruroides noxius Hoffmann FEBS Letters, 320, 43-46.
Vaca,L. Gurrola,G.B. Possani,L.D. Kunze,D.L.
1993. Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker Journal of Membrane Biology, 134, 123-129.
Becerril,B. Vazquez,A. Garcia,C. Corona,M. Bolivar,F. Possam,L.D.
1993. Cloning and characterization of cDNAs that code for Na(+)-channel-blocking toxins of the scorpion Centruroides noxius Hoffmann Gene, 128, 165-171.
Becerril,B. Corona,M. Mejia,M.C. Martin,B.M. Lucas,S. Bolivar,F. Possani,L.D.
1993. The genomic region encoding toxin gamma from the scorpion Tityus serrulatus contains an intron FEBS Letters, 335, 6-8.
Possani,L.D. Fletcher,P.L. Fletcher,M.D. Rode,G.S. Mochca-Morales,J. Lucas,S. Coronas,F.V. Alagon,A.C. Martin,B.M.
1992. Structural and functional characteristics of toxins purified from the venom of the Brazilian scorpion Tityus serrulatus Lutz and Mello Memorias do Instituto Butantan, 54, 35-52.
Zamudio,F. Saavedra,R. Martin,B.M. Gurrola-Briones,G. Herion,P. Possani,L.D.
1992. Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann European Journal of Biochemistry, 204, 281-292.
Estrada,I.C. Gutierrez,M.C. Esparza,J. Quesada-Pascual,F. Estrada-Parra,S. Possani,L.D.
1992. Use of synthetic peptides corresponding to sequences of Mycobacterium leprae proteins to study delayed-type hypersensitivity response in sensitized guinea pigs International Journal of Leprosy, 60, 18-27.
Possani,L.D. Mochca-Morales,J. Amezcua,J. Martin,B.M. Prestipino,G. Nobile,M.
1992. Anionic currents of chick sensory neurons are affected by a phospholipase A2 purified from the venom of the taipan snake Biochimica et Biophysica Acta (BBA), 1134, 210-216.
Fletcher,P.L. Fletcher,M.D. Possani,L.D.
1992. Characteristics of pancreatic exocrine secretion produced by venom from the Brazilian scorpion, Tityus serrulatus.European Journal of Cell Biology, 58, 259-270.
Valdivia,H.H. Martin,B.M. Escobar,L. Possani,L.D.
1992. Noxiustoxin and leiurutoxin III, two homologous peptide toxins with binding properties to synaptosomal membrane K+ channels.Biochemistry International, 27, 953-962.
Possani,L.D. Martin,B.M. Yatani,A. Mochca-Morales,J. Zamudio,F.Z. Gurrola,G.B. Brown,A.M.
1992. Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels Toxicon, 30, 1343-1364.
Harvey,A.L. Marshall,D.L. Possani,L.D.
1992. Dendrotoxin-like effects of noxiustoxin Toxicon, 30, 1497-1500.
Possani,L.D. Martin,B.M. Fletcher,M.D. Fletcher,P.L.
1991. Discharge effect on pancreatic exocrine secretion produced by toxins purified from Tityus serrulatus scorpion venom Journal of Biological Chemistry, 266, 3178-3185.
Possani,L.D.
1990. 3Rd Pan-American Symposium on Animal, Plant and Microbial Toxins, Oaxtepec, Morelos-State, Mexico Toxicon, 28, 597-597.
Mochca-Morales,J. Martin,B.M. Possani,L.D.
1990. Isolation and characterization of helothermine, a novel toxin from Heloderma horridum horridum (Mexican beaded lizard) venom Toxicon, 28, 299-309.
Ramirez,G.A. Fletcher,P.L. Possani,L.D.
1990. Characterization of the venom from Crotalus molossus nigrescens Gloyd (black tail rattlesnake): isolation of two proteases Toxicon, 28, 285-297.
Colden-Stanfield,M. Schilling,W.P. Possani,L.D. Kunze,D.L.
1990. Bradykinin-induced potassium current in cultured bovine aortic endothelial cells Journal of Membrane Biology, 116, 227-238 * .
Kirsch,G.E. Skattebol,A. Possani,L.D. Brown,A.M.
1989. Modification of Na channel gating by an alpha scorpion toxin from Tityus serrulatus Journal of General Physiology, 93, 67-83.
Gurrola,G.B. Molinar-Rode,R. Sitges,M. Bayon,A. Possani,L.D.
1989. Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portion Journal of Neural Transmission, 77, 11-20.
Prestipino,G. Valdivia,H.H. Lievano,A. Darszon,A. Ramirez,A.N. Possani,L.D.
1989. Purification and reconstitution of potassium channel proteins from squid axon membranes FEBS Letters, 250, 570-574.
Martin,B.M. Carbone,E. Yatani,A. Brown,A.M. Ramirez,A.N. Gurrola,G.B. Possani,L.D.
1988. Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann Toxicon, 26, 785-794.
Ramirez,A.N. Gurrola,G.B. Martin,B.M. Possani,L.D.
1988. Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann Toxicon, 26, 773-783.
Valdivia,H.H. Smith,J.S. Martin,B.M. Coronado,R. Possani,L.D.
1988. Charybdotoxin and noxiustoxin, two homologous peptide inhibitors of the K+ (Ca2+) channel FEBS Letters, 226, 280-284.
Yatani,A. Kirsch,G.E. Possani,L.D. Brown,A.M.
1988. Effects of New World scorpion toxins on single-channel and whole cell cardiac sodium currents American Journal of Physiology Heart and Circulatory Physiology, 254, H443-H451.
Alagon,A.C. Guzman,H.S. Martin,B.M. Ramirez,A.N. Carbone,E. Possani,L.D.
1988. Isolation and characterization of two toxins from the Mexican scorpion Centruroides limpidus limpidus Karsch Comp.Biochem.Physiol.B Biochem.Mol.Biol., 89, 153-161.
Carbone,E. Prestipino,G. Spadavecchia,L. Franciolini,F. Possani,L.D.
1987. Blocking of the squid axon K+ channel by noxiustoxin: a toxin from the venom of the scorpion Centruroides noxius Pflugers Archiv European Journal of Physiology, 408, 423-431.
Sitges,M. Possani,L.D. Bayon,A.
1987. Characterization of the actions of toxins II-9.2.2 and II-10 from the venom of the scorpion Centruroides noxius on transmitter release from mouse brain synaptosomes Journal of Neurochemistry, 48, 1745-1752.
Brown,A.M. Yatani,A. Lacerda,A.E. Gurrola,G.B. Possani,L.D.
1987. Neurotoxins that act selectively on voltage-dependent cardiac calcium channels Circulation Research, 61, I6-I9.
Rodriguez,A. Tablero,M. Barragan,B. Lara,P. Rangel,M. Arreguin,B. Possani,L. Soriano-Garcia,M.
1986. Crystallization of Hevein Journal of Crystal Growth, 76, 710-714 * .
Sosa,B.P. Alagon,A.C. Martin,B.M. Possani,L.D.
1986. Biochemical characterization of the phospholipase A2 purified from the venom of the Mexican beaded lizard (Heloderma horridum horridum Wiegmann) Biochemistry, 25, 2927-2933 * .
Sitges,M. Possani,L.D. Bayon,A.
1986. Noxiustoxin, a short-chain toxin from the Mexican scorpion Centruroides noxius, induces transmitter release by blocking K+ permeability Journal of Neuroscience, 6, 1570-1574 * .
Alagon,A. Possani,L.D. Smart,J. Schleuning,W.D.
1986. Helodermatine, a kallikrein-like, hypotensive enzyme from the venom of Heloderma horridum horridum (Mexican beaded lizard) Journal of Experimental Medicine, 164, 1835-1845.
Possani,L.D. Martin,B.M. Svendsen,I. Rode,G.S. Erickson,B.W.
1985. Scorpion toxins from Centruroides noxius and Tityus serrulatus. Primary structures and sequence comparison by metric analysis Biochemical Journal, 229, 739-750 * .
Carbone,E. Prestipino,G. Franciolini,F. Dent,M.A. Possani,L.D.
1984. Selective modification of the squid axon Na currents by Centruroides noxius toxin II-10 Journal de Physiologie, 79, 179-184 * .
Carbone,E. Wanke,E. Prestipino,G. Possani,L.D. Maelicke,A.
1982. Selective Action of Purified Scorpion Neurotoxins on the Ionic Currents of the Squid Giant-Axon.Hoppe-Seylers Zeitschrift fur Physiologische Chemie, 363, 1299-1300 * .
Possani,L.D. Martin,B.M. Svendsen,I.B.
1982. The Primary Structure of Noxiustoxin Carlsberg Research Communications, 47, 285-289 * .
Alagon,A.C. Maldonado,M.E. Julia,J.Z. Sanchez,C.R. Possani,L.D.
1982. Venom from two sub-species of Heloderma horridum (Mexican beaded lizard): general characterization and purification of N-benzoyl-L-arginine ethyl ester hydrolase Toxicon, 20, 463-475 * .
Carbone,E. Wanke,E. Prestipino,G. Possani,L.D. Maelicke,A.
1982. Selective blockage of voltage-dependent K+ channels by a novel scorpion toxin Nature, 296, 90-91 * .
Trejo,A.C. Possani,L.D.
1982. Electron microscopic evidence for scorpion toxin binding to synapses of rat brain cortex Neuroscience Letters, 32, 103-108 * .
Possani,L.D. Dent,M.A.R. Martin,B.M. Maelicke,A. Svendsen,I.
1981. The Amino Terminal Sequence of Several Toxins from the Venom of the Mexican Scorpion Centruroides Noxius Hoffmann Carlsberg Research Communications, 46, 207-214 * .
Possani,L.D. Martin,B.M. Mochcamorales,J. Svendsen,I.
1981. Purification and Chemical Characterization of the Major Toxins from the Venom of the Brazilian Scorpion Tityus Serrulatus Lutz and Mello Carlsberg Research Communications, 46, 195-205 * .
Perez de la Mora,M. Possani,L.D. Tapia,R. Teran,L. Palacios,R. Fuxe,K. Hokfelt,T. Ljungdahl,A.
1981. Demonstration of central gamma-aminobutyrate-containing nerve terminals by means of antibodies against glutamate decarboxylase Neuroscience, 6, 875-895 * .
Possani,L.D. Fernandez de Castro,J. Julia,J.Z.
1981. Detoxification with glutaraldehyde of purified scorpion (Centruroides noxius Hoffmann) venom Toxicon, 19, 323-329 * .
Possani,L. Steinmetz,W.E. Dent,M.A. Alagon,A.C. Wuthrich,K.
1981. Preliminary spectroscopic characterization of six toxins from Latin American scorpions Biochimica et Biophysica Acta (BBA), 669, 183-192 * .
Dent,M.A. Possani,L.D. Ramirez,G.A. Fletcher,P.L.
1980. Purification and characterization of two mammalian toxins from the venom of the Mexican scorpion Centruroides noxius Hoffmann Toxicon, 18, 343-350 * .
Possani,L.D. Sosa,B.P. Alagon,A.C. Burchfield,P.M.
1980. The venom from the snakes Agkistrodon bilineatus Taylori and Crotalus durissus Totonacus: lethality, biochemical and immunological properties Toxicon, 18, 356-360 * .
Possani,L.D. Fletcher,P.L. Alagon,A.B. Alagon,A.C. Julia,J.Z.
1980. Purification and characterization of a mammalian toxin from venom of the Mexican scorpion, Centruroides limpidus tecomanus Hoffmann Toxicon, 18, 175-183 * .
Alagon,A.C. Molinar,R.R. Possani,L.D. Fletcher,P.L. Cronan,J.E. Julia,J.Z.
1980. Venom from the snake Bothrops asper Garman. Purification and characterization of three phospholipases A2 Biochemical Journal, 185, 695-704 * .
Sosa,B.P. Alagon,A.C. Possani,L.D. Julia,J.Z.
1979. Comparison of phospholipase activity with direct and indirect lytic effects of animal venoms upon human red cells Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 64, 231-234 * .
Possani,L.D. Alagon,A.C. Fletcher,P.L. Varela,M.J. Julia,J.Z.
1979. Purification and characterization of a phospholipase A2 from the venom of the coral snake, Micrurus fulvius microgalbineus (Brown and Smith) Biochemical Journal, 179, 603-606 * .
Hokfelt,T. Elde,R. Fuxe,K. Johansson,O. Ljungdahl,A. Goldstein,M. Luft,R. Efendic,S. Nilsson,G. Terenius,L. Ganten,D. Jeffcoate,S.L. Rehfeld,J. Said,S. Perez de la Mora,M. Possani,L. Tapia,R. Teran,L. Palacios,R.
1978. Aminergic and peptidergic pathways in the nervous system with special reference to the hypothalamus.Research publications, 56, 69-135 * .
Bayon,A. Possani,L.D. Rode,G. Tapia,R.
1978. Kinetics of brain glutamate decarboxylase. Dead-end and product inhibition studies Journal of Neurochemistry, 30, 1629-1631 * .
Possani,L.D. Ramirez,G.A. Fletcher,P.L. Gurrola,M.A.
1978. Isolation of two mammalian toxins from the venom of the Mexican scorpion Centruroides elegans (Thorell) FEBS Letters, 91, 261-264 * .
Possani,L.D. Bayon,A. Tapia,R.
1977. Synthesis of affinity chromatography resins for the purification of brain glutamate decarboxylase Neurochemical Research, 2, 51-57 * .
Possani,L.D. Alagon,A.C. Fletcher,P.L. Erickson,B.W.
1977. Purification and properties of mammalian toxins from the venom of Brazilian Scorpion Tityus serrulatus Lutz and Mello Archives of Biochemistry and Biophysics, 180, 394-403 * .
Bayon,A. Possani,L.D. Tapia,R.
1977. Kinetics of brain glutamate decarboxylase. Inhibition studies with N-(5'-phosphopyridoxyl) amino acids Journal of Neurochemistry, 29, 513-517 * .
Bayon,A. Possani,L.D. Tapia,M. Tapia,R.
1977. Kinetics of brain glutamate decarboxylase. Interactions with glutamate, pyridoxal 5'-phosphate and glutamate-pyridoxal 5'-phosphate Schiff base Journal of Neurochemistry, 29, 519-525 * .
Possani,L.D.
1973. GABA effects and GABA receptors in neuromuscular junctions of crustaceans: analysis of some stereochemical models.Brazilian Journal of Medical and Biological Research, 6, 31-42 * .
Klett,R.P. Fulpius,B.W. Cooper,D. Smith,M. Reich,E. Possani,L.D.
1973. The acetylcholine receptor. I. Purification and characterization of a macromolecule isolated from Electrophorus electricus Journal of Biological Chemistry, 248, 6841-6853 * .
Tondo,C.V. Possani,L.D.
1972. Study of the bimodal frequency distribution of the relative concentration of hemoglobin S in heterozygous carriers.Revista brasileira de pesquisas medicas e biologicas, 5, 47-56 * .
Possani,L.D. Banerjee,R. Balny,C. Douzou,P.
1970. Oxidation of haemoglobin by oxygen in light: possible role of singlet oxygen Nature, 226, 861-862 * .
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