IBT-UNAM : Dr. Mario Enrique Zurita Ortega
Dr. Mario Enrique Zurita Ortega Grupo
Departamento de Genética del Desarrollo y Fisiología Molecular
Líneas de investigación
email: marioz @ibt.unam.mx
Teléfonos
Oficina +52 (777) 329-1659 red UNAM 27659 +52 (777) 311-4900 ext 225 Laboratorio +52 (777) 329-1631 red UNAM 27631 +52 (777) 311-4900 ext 225
- Licenciatura: Biología, Escuela de Biología, Fac. de Ciencias-UNAM (1981)
Presidente de la Sociedad Latinoamericana de Biología del Desarrollo (2008) Miembro del consejo editorial de Genesis The Journal of Genetics and Development (2007) Howard Hughes Medical Institute International Research Scholar 2002-2006 (2002) Coordinador regional del comité de selección para becarios de las becas Pew (2002)
Estudiantes Biol. Eduardo Calvario
Elizabeth Márquez
Malinalli Gómez
Lic. Ximena Gutiérrez "Transcriptómica comparativa de la embriogénesis en Anastrepha ludens"
M.C. Andrea Ortega
M.C. Maritere Uriostegui
Ing. Francisco Miguel Rios
Jessica Samantha Cruz
Biol. Miguel Angel Jimenez
Publicaciones recientes
Wappner,P. Zurita,M.
2020. The Latin American Society for Developmental Biology: A Successful History International Journal of Developmental Biology, Aug 5 Online ahead of print, .
Meyer-Nava,S. Nieto-Caballero,V.E. Zurita,M. Valadez-Graham,V.
2020.
Insights into HP1a-Chromatin Interactions Cells, 9, 1866.
Uriostegui-Arcos,M. Aguayo-Ortiz,R. Valencia-Morales,M.D.P. Melchy-Perez,E. Rosenstein,Y. Dominguez,L. Zurita,M.
2020. Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer Open Biology, 10, 200050.
Gutierrez-Ramos,X. Vazquez,M. Dorantes-Acosta,A.E. Diaz-Fleischer,F. Peralta-Alvarez,C.A. Nunez-Martinez,H.N. Arzate-Mejia,R.G. Recillas-Targa,F. Arteaga-Vazquez,M.A. Zurita,M.
2020. Novel tephritid-specific features revealed from cytological and transcriptomic analysis of Anastrepha ludens embryonic development Insect Biochemistry and Molecular Biology, 122, 103412.
Meyer-Nava,S. Torres,A. Zurita,M. Valadez-Graham,V.
2020. Molecular effects of dADD1 misexpression in chromatin organization and transcription BMC Molecular and Cell Biology, 21, 17.
Zurita,M. Murillo-Maldonado,J.M.
2020. Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases International Journal of Molecular Sciences, 21, 630.
Diaz-Gonzalez,S.D.M. Rodriguez-Aguilar,E.D. Meneses-Acosta,A. Valadez-Graham,V. Deas,J. Gomez-Ceron,C. Tavira-Montalvan,C.A. Arizmendi-Heras,A. Ramirez-Bello,J. Zurita-Ortega,M.E. Illades-Aguiar,B. Leyva-Vazquez,M.A. Fernandez-Tilapa,G. Bermudez-Morales,V.H. Madrid-Marina,V. Rodriguez-Dorantes,M. Perez-Plasencia,C. Peralta-Zaragoza,O.
2019. Transregulation of microRNA miR-21 promoter by AP-1 transcription factor in cervical cancer cells Cancer Cell International, 19, 214.
Bucio-Mendez,A. Cruz-Becerra,G. Valadez-Graham,V. Dinkova,T.D. Zurita,M.
2019. The Dmp8-Dmp18 bicistron messenger RNA enables unusual translation during cellular stress Journal of Cellular Biochemistry, 120, 3887-3897.
Rosales-Vega,M. Hernandez-Becerril,A. Murillo-Maldonado,J.M. Zurita,M. Vazquez,M.
2018. The role of the trithorax group TnaA isoforms in Hox gene expression, and in Drosophila late development PLoS ONE, 13, e0206587.
Cruz-Becerra,G. Valerio-Cabrera,S. Juarez,M. Bucio-Mendez,A. Zurita,M.
2018. TFIIH is highly dynamic during zygotic genome activation in Drosophila and its depletion causes catastrophic mitosis Journal of Cell Science, 131, jcs211631.
Gurrion,C. Uriostegui,M. Zurita,M.
2017. Heterochromatin Reduction Correlates with the Increase of the KDM4B and KDM6A Demethylases and the Expression of Pericentromeric DNA during the Acquisition of a Transformed Phenotype Journal of Cancer, 8, 2866-2875.
Chavez,J. Murillo-Maldonado,J.M. Bahena,V. Cruz,A.K. Castaneda-Sortibran,A. Rodriguez-Arnaiz,R. Zurita,M. Valadez-Graham,V.
2017. dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres Chromosoma, 126, 697-712.
Tue,N.T. Yoshioka,Y. Mizoguchi,M. Yoshida,H. Zurita,M. Yamaguchi,M.
2017. DREF plays multiple roles during Drosophila development Biochimica et Biophysica Acta (BBA), 1860, 705-712.
Monribot-Villanueva,J. Zurita,M. Vazquez,M.
2017. Developmental transcriptional regulation by SUMOylation, an evolving field Genesis, 55, e23009.
Miranda-Rodriguez,J.R. Salas-Vidal,E. Lomeli,H. Zurita,M. Schnabel,D.
2017. RhoA/ROCK pathway activity is essential for the correct localization of the germ plasm mRNAs in zebrafish embryos Developmental Biology, 421, 27-42.
Zurita,M. Cruz-Becerra,G.
2016. TFIIH: New Discoveries Regarding its Mechanisms and Impact on Cancer Treatment Journal of Cancer, 7, 2258-2265.
Cruz-Becerra,G. Juarez,M. Valadez-Graham,V. Zurita,M.
2016. Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation Open Biology, 6, .
Lopez-Falcon,B. Meyer-Nava,S. Hernandez-Rodriguez,B. Campos,A. Montero,D. Rudino,E. Vazquez,M. Zurita,M. Valadez-Graham,V.
2014. Characterization of the Drosophila Group Ortholog to the Amino-Terminus of the Alpha-Thalassemia and Mental Retardation X-Linked (ATRX) Vertebrate Protein PLoS ONE, 9, e113182 [correction in 2016 Feb 10;11(2):e0149367].
Villicana,C. Cruz,G. Zurita,M.
2014. The basal transcription machinery as a target for cancer therapy Cancer Cell International, 14, 18.
Monribot-Villanueva,J. Juarez-Uribe,R.A. Palomera-Sanchez,Z. Gutierrez-Aguiar,L. Zurita,M. Kennison,J.A. Vazquez,M.
2013. TnaA, an SP-RING Protein, Interacts with Osa, a Subunit of the Chromatin Remodeling Complex BRAHMA and with the SUMOylation Pathway in Drosophila melanogaster PLoS ONE, 8, e62251.
Villicana,C. Cruz,G. Zurita,M.
2013. The genetic depletion or the triptolide inhibition of TFIIH in p53 deficient cells induce a JNK-dependent cell death in Drosophila Journal of Cell Science, 126, 2502-2515.
Herrera-Cruz,M. Cruz,G. Valadez-Graham,V. Fregoso-Lomas,M. Villicana,C. Vazquez,M. Reynaud,E. Zurita,M.
2012. Physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA-repair/transcription factor TFIIH Journal of Biological Chemistry, 287, 33567-33580.
Yoshioka,Y. Tue,N.T. Fujiwara,S. Matsuda,R. Valadez-Graham,V. Zurita,M. Yamaguchi,M.
2012. Drosophila DREF acting via the JNK pathway is required for thorax development Genesis, 50, 599-611.
Valadez-Graham,V. Yoshioka,Y. Velazquez,O. Kawamori,A. Vazquez,M. Neumann,A. Yamaguchi,M. Zurita,M.
2012. XNP/dATRX interacts with DREF in the chromatin to regulate gene expression Nucleic Acids Research, 40, 1460-1474.
Hernandez-Vargas,R. Fonseca-Ornelas,L. Lopez-Gonzalez,I. Riesgo-Escovar,J. Zurita,M. Reynaud,E.
2011. Synphilin suppresses a-synuclein neurotoxicity in a Parkinson's disease Drosophila model Genesis, 49, 392-402.
Reyes-Carmona,S. Valadez-Graham,V. Aguilar-Fuentes,J. Zurita,M. Leon Del-Rio,A.
2011. Trafficking and chromatin dynamics of holocarboxylase synthetase during development of Drosophila melanogaster Molecular Genetics and Metabolism, 103, 240-248.
Palomera-Sanchez,Z. Zurita,M.
2011. Open, repair and close again: Chromatin dynamics and the response to UV-induced DNA damage DNA Repair, 10, 119-125.
Palomera-Sanchez,Z. Bucio-Mendez,A. Valadez-Graham,V. Reynaud,E. Zurita,M.
2010. Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV induced DNA damage to demethylate histone H3-lysine 9 Journal of Biological Chemistry, 285, 31370-31379.
Aguilar-Fuentes,J. Fregoso,M. Herrera,M. Reynaud,E. Braun,C. Egly,J.M. Zurita,M.
2008. p8/TTDA Overexpression Enhances UV-Irradiation Resistance and Suppresses TFIIH Mutations in a Drosophila Trichothiodystrophy Model PLoS Genetics, 4, e1000253.
Vazquez,M. Cooper,M.T. Zurita,M.E. Kennison,J.A.
2008. {gamma}Tub23C interacts genetically with Brahma chromatin-remodeling complexes in Drosophila melanogaster Genetics, 180, 835-843.
Carballar-Lejarazu,R. Rodriguez,M.H. De La Cruz Hernandez-Hernandez,F. Ramos-Castaneda,J. Possani,L.D. Zurita-Ortega,M. Reynaud-Garza,E. Hernandez-Rivas,R. Loukeris,T. Lycett,G. Lanz-Mendoza,H.
2008. Recombinant scorpine: a multifunctional antimicrobial peptide with activity against different pathogens Cellular and Molecular Life Sciences, 65, 3081-3092.
Zurita,M. Reynaud,E. Aguilar-Fuentes,J.
2008. From the beginning: the basal transcription machinery and onset of transcription in the early animal embryo Cellular and Molecular Life Sciences, 65, 212-227.
Fregoso,M. Laine,J.P. Aguilar-Fuentes,J. Moquet,V. Reynaud,E. Coin,F. Egly,J.M. Zurita,M.
2007. DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility Molecular and Cellular Biology, 27, 3640-3650.
Aguilar-Fuentes,J. Valadez-Graham,V. Reynaud,E. Zurita,M.
2006. TFIIH trafficking and its nuclear assembly during early Drosophila embryo development Journal of Cell Science, 119, 3866-3875.
Rodriguez-Valentin,R. Lopez-Gonzalez,I. Jorquera,R. Labarca,P. Zurita,M. Reynaud,E.
2006. Oviduct contraction in Drosophila is modulated by a neural network that is both, octopaminergic and glutamatergic Journal of Cellular Physiology, 209, 183-198.
Rebollar,E. Valadez-Graham,V. Vazquez,M. Reynaud,E. Zurita,M.
2006. Role of the p53 homologue from Drosophila melanogaster in the maintenance of histone H3 acetylation and response to UV-light irradiation FEBS Letters, 580, 642-648.
Gutierrez,L. Merino,C. Vazquez,M. Reynaud,E. Zurita,M.
2004. RNA polymerase II 140(wimp) mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila Genesis, 40, 58-66.
Zurita,M. Merino,C.
2003. The transcriptional complexity of the TFIIH complex Trends in Genetics, 19, 578-584.
Gutierrez,L. Zurita,M. Kennison,J.A. Vazquez,M.
2003. The Drosophila trithorax group gene tonalli(tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein Development, 130, 343-354.
Vazquez,M. Rodriguez,R. Zurita,M.
2002. A new peroxinectin-like gene preferentially expressed during oogenesis and early embryogenesis in Drosophila melanogaster Development Genes and Evolution, 212, 526-529.
Castro,J. Merino,C. Zurita,M.
2002. Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly DNA Repair, 1, 359-368.
Possani,L.D. Corona,M. Zurita,M. Rodriguez,M.H.
2002. From Noxiustoxin to Scorpine and Possible Transgenic Mosquitoes Resistant to Malaria Archives of Medical Research, 33, 398-404.
Merino,C. Reynaud,E. Vazquez,M. Zurita,M.
2002. DNA Repair and Transcriptional Effects of Mutations in TFIIH in Drosophila Development Molecular Biology of the Cell, 13, 3246-3256.
Corona,M. Valdez-Cruz,N.A. Merino,E. Zurita,M. Possani,L.D.
2001. Genes and peptides from the scorpion Centruroides sculpturatus Ewing, that recognize Na(+)-channels Toxicon, 39, 1893-1898.
Sandoval,M.T. Zurita,M.
2001. Increased UV light sensitivity in transgenic Drosophila expressing the antisense XPD homolog Antisense and Nucleic Acid Drug Development, 11, 125-128.
Corona,M. Estrada,E. Zurita,M.
1999. Differential expression of mitochondrial genes between queens and workers during caste determination in the honeybee Apis mellifera Journal of Experimental Biology, 202, 929-938.
Reynaud,E. Lomeli,H. Vazquez,M. Zurita,M.
1999. The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes Molecular Biology of the Cell, 10, 1191-1203.
Perezgasga,L. Segovia,L. Zurita,M.
1999. Molecular characterization of the 5' control region and of two lethal alleles affecting the hsp60 gene in Drosophila melanogaster FEBS Letters, 456, 269-273.
Reynaud,E. Vazquez,M. Zurita,M.
1998. Molecular analysis and chromosome mapping of the H2A, H3 and H4 histone genes from the malaria vector Anopheles gambiae Insect Molecular Biology, 7, 385-391.
Possani,L.D. Zurita,M. Delepierre,M. Hernandez,F.H. Rodriguez,M.H.
1998. From noxiustoxin to Shiva-3, a peptide toxic to the sporogonic development of Plasmodium berghei Toxicon, 36, 1683-1692.
Zurita,M. Reynaud,E. Kafatos,F.C.
1997. Cloning and characterization of cDNAs preferentially expressed in the ovary of the mosquito, Anopheles gambiae Insect Molecular Biology, 6, 55-62.
Reynaud,E. Bolshakov,V.N. Barajas,V. Kafatos,F.C. Zurita,M.
1997. Antisense suppression of the putative ribosomal protein S3A gene disrupts ovarian development in Drosophila melanogaster Molecular and General Genetics, 256, 462-467.
Kozlova,T. Perezgasga,L. Reynaud,E. Zurita,M.
1997. The Drosophila melanogaster homologue of the hsp60 gene is encoded by the essential locus l(1)10Ac and is differentially expressed during fly development Development Genes and Evolution, 207, 253-263.
Corona,M. Zurita,M. Possani,L.D. Becerril,B.
1996. Cloning and characterization of the genomic region encoding toxin IV-5 from the scorpion Tityus serrulatus Lutz and Mello Toxicon, 34, 251-256.
Michel,B. Lizardi,P.M. Alagon,A. Zurita,M.
1995. Identification and analysis of the start site of ribosomal RNA transcription of Entamoeba histolytica Molecular and Biochemical Parasitology, 73, 19-30.
Michel,B. Alagon,A. Lizardi,P.M. Zurita,M.
1992. Characterization of a repetitive DNA element from Entamoeba histolytica Molecular and Biochemical Parasitology, 51, 165-168.
Iltzsch,M.H. Bieber,D. Vijayasarathy,S. Webster,P. Zurita,M. Ding,J.Z. Mansour,T.E.
1992. Cloning and characterization of a cDNA coding for the a-subunit of a stimulatory G protein from Schistosoma mansoni Journal of Biological Chemistry, 267, 14504-14508 * .
Zurita,M. Alagon,A. Vargas-Villarreal,J. Lizardi,P.M.
1991. The Entamoeba histolytica rDNA episome: nuclear localization, DNAase I sensitivity map, and specific DNA-protein interactions Molecular Microbiology, 5, 1843-1851.
Zurita,M. Bieber,D. Mansour,T.E.
1989. Identification, expression and in situ hybridization of an eggshell protein gene from Fasciola hepatica Molecular and Biochemical Parasitology, 37, 11-18 * .
Zurita,M. Bieber,D. Ringold,G. Mansour,T.E.
1988. cDNA cloning and gene characterization of the mitochondrial large subunit (LSU) rRNA from the liver fluke Fasciola hepatica. Evidence of heterogeneity in the fluke mitochondrial genome Nucleic Acids Res, 16, 7001-7012 * .
Zurita,M. Bieber,D. Ringold,G. Mansour,T.E.
1987. Cloning and characterization of a female genital complex cDNA from the liver fluke Fasciola hepatica Proceedings of the National Academy of Sciences of the United States of America, 84, 2340-2344 * .
Balbas,P. Soberon,X. Merino,E. Zurita,M. Lomeli,H. Valle,F. Flores,N. Bolivar,F.
1986. Plasmid vector pBR322 and its special-purpose derivatives--a review Gene, 50, 3-40.
Zurita,M. Bolivar,F. Soberon,X.
1984. Construction and characterization of new cloning vehicles. VII. Construction of plasmid pBR327par, a completely sequenced, stable derivative of pBR327 containing the par locus of pSC101 Gene, 28, 119-122.
Otras Publicaciones Uriostegui-Arcos,M. Aguayo-Ortiz,R. Valencia-Morales,M.P. Melchy-Perez,E. Rosenstein,Y. Dominguez,L. Zurita,M.
2019. Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer bioRxiv, Preprint posted December 03, 2019, 862508.
Zurita-Ortega,M.
2015. El Departamento de Biología Molecular del Instituto de Investigaciones Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 1, 29-30.
Zurita-Ortega,M.
2015. El Departamento de Biología Molecular del Instituto de Investigaciones Biomédicas y los inicios del IBt (2da. parte) Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 2, 29-30.
Zurita,M.
2004. Analisis del factor de transcripcion/reparacion TFIH en el desarrollo: el uso de drosophila como modelo TIP revista especializada en Ciencias Quimico-Biologicas, 7, 41-46.
* Indica publicación con otra institución de adscripción
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