IBT-UNAM : Dr. Humberto Flores Soto | Dr. Humberto Flores Soto
 Técnico Académico Grupo del Dr. Francisco Xavier Soberon | email: | humberto | @ibt.unam.mx |
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Teléfonos Oficina +52 (777) 311-4900 ext 218
Laboratorio +52 (777) 329-1605
desde la CDMX 562-27605
red UNAM 27605
+52 (777) 311-4900 ext 218
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- Licenciatura: Biologo, Fac. de Ciencias-UNAM (1989)
- Maestría: en Biotecnología, IBt-UNAM (1993)
- Doctorado: en Biotecnología, IBt-UNAM (1995)
- Mencion honorífica Maestría (1994)
- Medalla "Gabino Barreda" (1997)
Estudiantes
Mariana Gutiérrez
Publicaciones recientes
Torres-Quintero,M.C. Gomez,I. Pacheco,S. Sanchez,J. Flores,H. Osuna,J. Mendoza,G. Soberon,M. Bravo,A.
2018. Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicity Scientific Reports, 8, 4989.
Osuna,J. Flores,H. Gaytan,P.
2012. A reporter system that discriminates EF-hand-sensor motifs from signal-modulators at the single-motif level FEBS Letters, 586, 3398-3403.
Flores,H. Lin,S. Contreras-Ferrat,G. Cronan,J.E. Morett,E.
2012. Evolution of a new function in an esterase: simple amino acid substitutions enable the activity present in the larger paralog, BioH Protein Engineering Design & Selection, 25, 387-395.
Osuna,J. Flores,H. Saab-Rincon,G.
2012. The beta1 domain of protein G can replace the chorismate mutase domain of the T-protein FEBS Letters, 586, 466-471.
Morett,E. Saab-Rincon,G. Olvera,L. Olvera,M. Flores,H. Grande,R.
2008. Sensitive Genome-Wide Screen for Low Secondary Enzymatic Activities: The YjbQ Family Shows Thiamin Phosphate Synthase Activity Journal of Molecular Biology, 376, 839-853.
Flores,H. Ellington,A.D.
2005. A modified consensus approach to mutagenesis inverts the cofactor specificity of Bacillus stearothermophilus lactate dehydrogenase Protein Engineering Design & Selection, 18, 369-377.
Flores,H. Ellington,A.D.
2002. Increasing the thermal stability of an oligomeric protein, beta-glucuronidase Journal of Molecular Biology, 315, 325-337 * .
Juarez,K. Flores,H. Davila,S. Olvera,L. Gonzalez,V. Morett,E.
2000. Reciprocal domain evolution within a transactivator in a restricted sequence space Proceedings of the National Academy of Sciences of the United States of America, 97, 3314-3318.
Flores,H. Soberon,X. Sanchez,J. Bravo,A.
1997. Isolated domain II and III from the Bacillus thuringiensis Cry1Ab delta-endotoxin binds to lepidopteran midgut membranes FEBS Letters, 414, 313-318.
Muir,R.S. Flores,H. Zinder,N.D. Model,P. Soberon,X. Heitman,J.
1997. Temperature-sensitive mutants of the EcoRI endonuclease Journal of Molecular Biology, 274, 722-737.
Flores,H. Osuna,J. Heitman,J. Soberon,X.
1995. Saturation mutagenesis of His114 of EcoRI reveals relaxed-specificity mutants Gene, 157, 295-301.
Osuna,J. Flores,H. Soberon,X.
1994. Microbial systems and directed evolution of protein activities Critical Reviews in Microbiology, 20, 107-116.
Osuna,J. Flores,H. Soberon,X.
1991. Combinatorial mutagenesis of three major groove-contacting residues of EcoRI: single and double amino acid replacements retaining methyltransferase-sensitive activities Gene, 106, 7-12.
* Indica publicación con otra institución de adscripción
