IBT-UNAM : Dr. Martin Gustavo Pedraza Alva
Dr. Martin Gustavo Pedraza Alva Grupo
Departamento de Medicina Molecular y Bioprocesos
Líneas de investigación
email: gustavo @ibt.unam.mx
Teléfonos
Oficina +52 (777) 329-1777 ext 38269. red UNAM 38269 Laboratorio +52 (777) 329-1777 ext 38259. red UNAM 38259
- Licenciatura: Biología, Fac. de Ciencias-UNAM (1986)
Estudiantes Lic. Daniela Denisse Ramirez
Biol. Victor Emmanuel Osio
Q.F.B. Alejandro Ramirez
Lic. Nilda del Carmen Sanchez
M.C. Edgardo Madrid
Biol. Luis Roman
Biol. Verónica Yutsil García
Biol. Jorge Luis Ochoa
Rafael Alejandro Maldonado
M.C. Jonathan Salazar
Publicaciones recientes
Licea-Cejudo,R.C. Arenas-Sandoval,L.K. Salazar-Leon,J. Martinez-Martinez,M.V. Carreon-Rodriguez,A. Pedraza-Alva,G. Perez-Martinez,L.
2020. A dysfunctional family environment and a high body fat percentage negatively affect telomere length in Mexican boys aged 8-10 years Acta Paediatrica, 109, 2091-2098.
Sanchez,N.C. Medrano-Jimenez,E. Aguilar-Leon,D. Perez-Martinez,L. Pedraza-Alva,G.
2020. Tumor Necrosis Factor-Induced miR-146a Upregulation Promotes Human Lung Adenocarcinoma Metastasis by Targeting Merlin DNA and Cell Biology, 39, 484-497.
Salazar-Leon,J. Valdez-Hernandez,A.L. Garcia-Jimenez,S. Roman-Dominguez,L. Huanosta-Murillo,E. Bonifaz,L.C. Perez-Martinez,L. Pedraza-Alva,G.
2019. Nlrp1b1 negatively modulates obesity-induced inflammation by promoting IL-18 production Scientific Reports, 9, 13815.
Ramirez-Serrano,C.E. Jimenez-Ferrer,E. Herrera-Ruiz,M. Zamilpa,A. Vargas-Villa,G. Ramirez-Carreto,R.J. Chavarria,A. Tortoriello,J. Pedraza-Alva,G. Perez-Martinez,L.
2019. A Malva parviflora's fraction prevents the deleterious effects resulting from neuroinflammation Biomedicine and Pharmacotherapy, 118, 109349.
Medrano-Jimenez,E. Jimenez-Ferrer Carrillo,I. Pedraza-Escalona,M. Ramirez-Serrano,C.E. Alvarez-Arellano,L. Cortes-Mendoza,J. Herrera-Ruiz,M. Jimenez-Ferrer,E. Zamilpa,A. Tortoriello,J. Pedraza-Alva,G. Perez-Martinez,L.
2019. Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer's disease by restoring microglial function via a PPAR-gamma-dependent mechanism Journal of Neuroinflammation, 16, 143.
Villasenor,T. Madrid-Paulino,E. Maldonado-Bravo,R. Perez-Martinez,L. Pedraza-Alva,G.
2019. Mycobacterium bovis BCG promotes IL-10 expression by establishing a SYK/PKCalpha/beta positive autoregulatory loop that sustains STAT3 activation Pathogens and Disease, 77, ftz032.
Pedraza-Alva,G. Ramirez-Serrano,C.E. Pedraza,F. Flores-Vallejo,R.C. Villarreal,M.L. Perez-Martinez,L.
2019. From traditional remedies to cutting-edge medicine: using ancient Mesoamerican knowledge to address complex disorders relevant to psychoneuroimmunology Brain, Behavior, and Immunity, 79, 3-5.
Ramirez-Carreto,S. Perez-Garcia,E.I. Salazar-Garcia,S.I. Bernaldez-Sarabia,J. Licea-Navarro,A. Rudino-Pinera,E. Perez-Martinez,L. Pedraza-Alva,G. Rodriguez-Almazan,C.
2019. Identification of a pore-forming protein from sea anemone Anthopleura dowii Verrill (1869) venom by mass spectrometry Journal of Venomous Animals and Toxins Including Tropical Diseases, 25, e144118.
Alvarez-Arellano,L. Pedraza-Escalona,M. Blanco-Ayala,T. Camacho-Concha,N. Cortes-Mendoza,J. Perez-Martinez,L. Pedraza-Alva,G.
2018. Autophagy impairment by caspase-1-dependent inflammation mediates memory loss in response to beta-Amyloid peptide accumulation Journal of Neuroscience Research, 96, 234-246.
Villasenor,T. Madrid-Paulino,E. Maldonado-Bravo,R. Urban-Aragon,A. Perez-Martinez,L. Pedraza-Alva,G.
2017. Activation of the Wnt Pathway by Mycobacterium tuberculosis: A Wnt-Wnt Situation Frontiers in Immunology, 8, 50.
Torres-Huerta,A. Villasenor,T. Flores-Alcantar,A. Parada,C. Aleman-Navarro,E. Espitia,C. Pedraza-Alva,G. Rosenstein,Y.
2017. The interaction of the CD43 sialomucin with the mycobacterium tuberculosis cpn60.2 chaperonin mediates macrophage TNF-alpha production Infection and Immunity, 85, e00915-16.
Bravo-Adame,M.E. Vera-Estrella,R. Barkla,B.J. Martinez-Campos,C. Flores-Alcantar,A. Ocelotl-Oviedo,J.P. Pedraza-Alva,G. Rosenstein,Y.
2017. An alternative mode of CD43 signal transduction activates pro-survival pathways of T lymphocytes Immunology, 150, 87-99.
Perez-Garcia,E.I. Meza-Sosa,K.F. Lopez-Sevilla,Y. Camacho-Concha,N. Sanchez,N.C. Perez-Martinez,L. Pedraza-Alva,G.
2015. Merlin negative regulation by miR-146a promotes cell transformation Biochemical and Biophysical Research Communications, 468, 594-600.
Pedraza-Alva,G. Perez-Martinez,L. Valdez-Hernandez,L. Meza-Sosa,K.F. Ando-Kuri,M.
2015. Negative regulation of the inflammasome: keeping inflammation under control Immunological Reviews, 265, 231-257.
Meza-Sosa,K.F. Perez-Garcia,E.I. Camacho-Concha,N. Lopez-Gutierrez,O. Pedraza-Alva,G. Perez-Martinez,L.
2014. MiR-7 Promotes Epithelial Cell Transformation by Targeting the Tumor Suppressor KLF4 PLoS ONE, 9, e103987.
Meza-Sosa,K.F. Pedraza-Alva,G. Perez-Martinez,L.
2014. microRNAs: key triggers of neuronal cell fate Frontiers in Cellular Neuroscience, 8, 175.
Ferat-Osorio,E. Sanchez-Anaya,A. Gutierrez-Mendoza,M. Bosco-Garate,I. Wong-Baeza,I. Pastelin-Palacios,R. Pedraza-Alva,G. Bonifaz,L.C. Cortes-Reynosa,P. Perez-Salazar,E. Arriaga-Pizano,L. Lopez-Macias,C. Rosenstein,Y. Isibasi,A.
2014. Heat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1/constitutive heat shock element-binding factor-dependent mechanism Journal of Inflammation (United Kingdom), 11, 19.
Camacho-Concha,N. Olivos-Ortiz,A. Nunez-Rivera,A. Pedroza-Saavedra,A. Gutierrez-Xicotencatl,L. Rosenstein,Y. Pedraza-Alva,G.
2013. CD43 Promotes Cells Transformation by Preventing Merlin-Mediated Contact Inhibition of Growth PLoS ONE, 8, e80806.
Cortes-Mendoza,J. Leon-Guerrero,S.D. Pedraza-Alva,G. Perez-Martinez,L.
2013. Shaping synaptic plasticity: the role of activity-mediated epigenetic regulation on gene transcription International Journal of Developmental Neuroscience, 31, 359-369.
Varga,Z. Gurrola-Briones,G. Papp,F. Rodriguez de la Vega,R.C. Pedraza-Alva,G. Tajhya,R.B. Gaspar,R. Cardenas,L. Rosenstein,Y. Beeton,C. Possani,L.D. Panyi,G.
2012. Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells Molecular Pharmacology, 82, 372-382.
Meza-Sosa,K.F. Valle-Garcia,D. Pedraza-Alva,G. Perez-Martinez,L.
2012. Role of microRNAs in central nervous system development and pathology Journal of Neuroscience Research, 90, 1-12.
Pedraza-Alva,G. Merida,L.B. Del Rio,R. Fierro,N.A. Cruz-Munoz,M.E. Olivares,N. Melchy,E. Igras,V. Hollander,G.A. Burakoff,S.J. Rosenstein,Y.
2011. CD43 regulates the threshold for T cell activation by targeting Cbl functions IUBMB Life, 63, 940-948.
Diaz de Leon-Guerrero,S. Pedraza-Alva,G. Perez-Martinez,L.
2011. In sickness and in health: the role of methyl-CpG binding protein 2 in the central nervous system European Journal of Neuroscience, 33, 1563-1574.
Pedraza-Alva,G. Zingg,J.M. Donda,A. Perez-Martinez,L.
2009. Estrogen receptor regulates MyoD gene expression by preventing AP-1-mediated repression Biochemical and Biophysical Research Communications, 389, 360-365.
Thornton,T.M. Pedraza-Alva,G. Deng,B. Wood,C.D. Aronshtam,A. Clements,J.L. Sabio,G. Davis,R.J. Matthews,D.E. Doble,B. Rincon,M.
2008. Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation Science, 320, 667-670 * .
Pedraza-Alva,G. Rosenstein,Y.
2007. CD43 Signal Transduction, 7, 372-385.
Fierro,N.A. Pedraza-Alva,G. Rosenstein,Y.
2006. TCR-Dependent Cell Response Is Modulated by the Timing of CD43 Engagement Journal of Immunology, 176, 7346-7353.
Farley,N. Pedraza-Alva,G. Serrano-Gomez,D. Nagaleekar,V. Aronshtam,A. Krahl,T. Thornton,T. Rincon,M.
2006. p38 Mitogen-Activated Protein Kinase Mediates the Fas-Induced Mitochondrial Death Pathway in CD8+ T Cells Molecular and Cellular Biology, 26, 2118-2129 * .
Pedraza-Alva,G. Koulnis,M. Charland,C. Thornton,T. Clements,J.L. Schlissel,M.S. Rincon,M.
2006. Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint Embo Journal, 25, 763-773.
Del Rio,R. Rincon,M. Layseca-Espinosa,E. Fierro,N.A. Rosenstein,Y. Pedraza-Alva,G.
2004. PKCtheta; is required for the activation of human T lymphocytes induced by CD43 engagement Biochemical and Biophysical Research Communications, 325, 133-143.
Rincon,M. Pedraza-Alva,G.
2003. JNK and p38 MAP kinases in CD4(+) and CD8(+) T cells Immunological Reviews, 192, 131-142 * .
Layseca-Espinosa,E. Pedraza-Alva,G. Montiel,J.L. Del Rio,R. Fierro,N.A. Gonzalez-Amaro,R. Rosenstein,Y.
2003. T cell aggregation induced through CD43: intracellular signals and inhibition by the immunomodulatory drug leflunomide Journal of Leukocyte Biology, 74, 1083-1093.
Guerra-Crespo,M. Charli,J.L. Rosales-Garcia,V. Pedraza-Alva,G. Perez-Martinez,L.
2003. Polyethylenimine improves the transfection efficiency of primary cultures of post-mitotic rat fetal hypothalamic neurons Journal of Neuroscience Methods, 127, 179-192.
Cruz-Munoz,M.E. Salas-Vidal,E. Salaiza-Suazo,N. Becker,I. Pedraza-Alva,G. Rosenstein,Y.
2003. The CD43 Coreceptor Molecule Recruits the zeta-Chain as Part of Its Signaling Pathway Journal of Immunology, 171, 1901-1908.
Pedraza-Alva,G. Sawasdikosol,S. Liu,Y.C. Merida,L.B. Cruz-Munoz,M.E. Oceguera-Yanez,F. Burakoff,S.J. Rosenstein,Y.
2001. Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells Journal of Biological Chemistry, 276, 729-737.
Santana,M.A. Pedraza-Alva,G. Olivares-Zavaleta,N. Madrid-Marina,V. Horejsi,V. Burakoff,S.J. Rosenstein,Y.
2000. CD43-mediated signals induce DNA binding activity of AP-1, NF-AT, and NFkappa B transcription factors in human T lymphocytes Journal of Biological Chemistry, 275, 31460-31468.
Rosenstein,Y. Santana,A. Pedraza-Alva,G.
1999. CD43, a molecule with multiple functions Immunol.Res., 20, 89-99.
Pedraza-Alva,G. Merida,L.B. Burakoff,S.J. Rosenstein,Y.
1998. T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation Journal of Biological Chemistry, 273, 14218-14224.
Pedraza-Alva,G. Merida,L.B. Burakoff,S.J. Rosenstein,Y.
1996. CD43-specific activation of T cells induces association of CD43 to Fyn kinase Journal of Biological Chemistry, 271, 27564-27568.
Pedraza-Alva,G. Zingg,J.M. Jost,J.P.
1994. AP-1 binds to a putative cAMP response element of the MyoD1 promoter and negatively modulates MyoD1 expression in dividing myoblasts Journal of Biological Chemistry, 269, 6978-6985 * .
Zingg,J.M. Pedraza-Alva,G. Jost,J.P.
1994. MyoD1 promoter autoregulation is mediated by two proximal E-boxes Nucleic Acids Research, 22, 2234-2241 * .
Shapira,M. Pedraza,G.
1990. Sequence analysis and transcriptional activation of heat shock protein 83 of Leishmania mexicana amazonensis Molecular and Biochemical Parasitology, 42, 247-255 * .
Montero L. Valdez-Hernandez,A.L. Perez-Lemus,C. Pedraza-Alva,G. 2013. Inflammasomes: Homeostasis guardians en: Ferat-Osorio,E. Molecular aspects of inflammation. Kerala. Research Signpost. pags. 43-69
Perez-Martinez,L. Pedraza-Alva,G. Ferat-Osorio,E. 2013. Molecular aspects of inflammation Kerala:. Research Signpost. 231 p.
Perez-Martinez,L. Pedraza-Alva,G. 2012. Cell signaling: From non-specific bands to posttranslational modifications-mediated protein-protein interactions en: *isabelg Tools to Understand Protein-Protein Interactions. Kerala. Transworld Research Network. pags. 21-40
Rosenstein,Y. Pedraza-Alva,G. 2008. La vida cotidiana de los linfocitos, o de los quehaceres de los inmunólogos en: *agustin Una ventana al quehacer científico. Instituto de Biotecnología de la UNAM 25 aniversario, cap 2. Mexico, D.F.. UNAM. pags. 1-8
Otras Publicaciones Licea-Cejudo,R.C. Pedraza-Alva,G. Perez-Martinez,L.
2018. Obesidad infantil: Crónica de una vejez anunciada Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 12, 17-19.
Pedraza-Alva,G. Torres-Huerta,A. Rosenstein,Y.
2015. Las intrincadas redes de la inmunidad Ciencia, Revista de la Academia Mexicana de Ciencia, 66, 27-35.
Meza-Sosa,K.F. Valle-Garcia,D. Pedraza-Alva,G. Perez-Martinez,L.
2013. MicroARNs, los pequeños grandes actores del sistema nervioso Ciencia, Revista de la Academia Mexicana de Ciencia, 64, 79-86.
* Indica publicación con otra institución de adscripción
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