IBT-UNAM : Dra. Georgina Gurrola Briones
Dra. Georgina Gurrola Briones
Grupo del Dr. Lourival Domingos Possani
email: georgina @ibt.unam.mx
Teléfonos
Oficina +52 (777) 311-4900 ext 215 Laboratorio +52 (777) 329-1669 red UNAM 27669 +52 (777) 311-4900 ext 215
- Licenciatura: Químico Farmaceutico Biologo, FES-Cuautitlan-UNAM (1979)
Estudiantes Biol. Rey Luis Mendoza
Jose Noe Vazquez
Lic. Aketzali Nallely Colin
Publicaciones recientes
Garcia-Guerrero,I.A. Carcamo-Noriega,E. Gomez-Lagunas,F. Gonzalez-Santillan,E. Zamudio,F.Z. Gurrola,G.B. Possani,L.D.
2020. Biochemical characterization of the venom from the Mexican scorpion Centruroides ornatus, a dangerous species to humans Toxicon, 173, 27-38.
Gurrola,G.B. Guijarro,J.I. Delepierre,M. Mendoza,R.L.L. Cid-Uribe,J.I. Coronas,F.V. Possani,L.D.
2019. Cn29, a novel orphan peptide found in the venom of the scorpion Centruroides noxius: Structure and function Toxicon, 167, 184-191.
Jaimes-Hoy,L. Gurrola,G.B. Cisneros,M. Joseph-Bravo,P. Possani,L.D. Charli,J.L.
2017. The Kv1.3 channel blocker Vm24 enhances muscle glucose transporter 4 mobilization but does not reduce body-weight gain in diet-induced obese male rats Life Sciences, 181, 23-30.
Xiao,L. Gurrola,G.B. Zhang,J. Valdivia,C.R. SanMartin,M. Zamudio,F.Z. Zhang,L. Possani,L.D. Valdivia,H.H.
2016. Structure-function relationships of peptides forming the calcin family of ryanodine receptor ligands Journal of General Physiology, 147, 375-394.
Zhao,Y.T. Valdivia,C.R. Gurrola,G.B. Powers,P.P. Willis,B.C. Moss,R.L. Jalife,J. Valdivia,H.H.
2015. Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function Proceedings of the National Academy of Sciences of the United States of America, 112, E1669-E1677.
Zhao,Y.T. Valdivia,C.R. Gurrola,G.B. Hernandez,J.J. Valdivia,H.H.
2015. Arrhythmogenic mechanisms in ryanodine receptor channelopathies Science China Life Sciences, 58, 54-58.
Ortiz,E. Gurrola,G.B. Schwartz,E.F. Possani,L.D.
2015. Scorpion venom components as potential candidates for drug development Toxicon, 93, 125-135.
Riano-Umbarila,L. Olamendi-Portugal,T. Morelos-Juarez,C. Gurrola,G.B. Possani,L.D. Becerril,B.
2013. A novel human recombinant antibody fragment capable of neutralizing Mexican scorpion toxins Toxicon, 76, 370-376.
Quintero-Hernandez,V. Jimenez-Vargas,J.M. Gurrola,G.B. Valdivia,H.H. Possani,L.D.
2013. Scorpion venom components that affect ion-channels function Toxicon, 76, 328-342.
Sanchez-Vasquez,L. Silva-Sanchez,J. Jimenez-Vargas,J.M. Rodriguez-Romero,A. Munoz-Garay,C. Rodriguez,M.C. Gurrola,G.B. Possani,L.D.
2013. Enhanced antimicrobial activity of novel synthetic peptides derived from vejovine and hadrurin Biochimica et Biophysica Acta (BBA), 1830, 3427-3436.
Varga,Z. Gurrola-Briones,G. Papp,F. Rodriguez de la Vega,R.C. Pedraza-Alva,G. Tajhya,R.B. Gaspar,R. Cardenas,L. Rosenstein,Y. Beeton,C. Possani,L.D. Panyi,G.
2012. Vm24, a Natural Immunosuppressant Peptide Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells Molecular Pharmacology, 82, 372-382.
Gurrola,G.B. Hernandez-Lopez,R.A. Rodriguez de la Vega,R.C. Varga,Z. Batista,C.V. Salas-Castillo,S.P. Panyi,G. del Rio-Portilla,F. Possani,L.D.
2012. Structure, function and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes Biochemistry, 51, 4049-4061.
Schiavon,E. Pedraza-Escalona,M. Gurrola,G.B. Olamendi-Portugal,T. Corzo,G. Wanke,E. Possani,L.D.
2012. Negative-shift activation, current reduction and resurgent currents induced by beta-toxins from Centruroides scorpions in sodium channels Toxicon, 59, 283-293.
Hernandez-Aponte,C.A. Silva-Sanchez,J. Quintero-Hernandez,V. Rodriguez-Romero,A. Balderas,C. Possani,L.D. Gurrola,G.B.
2011. Vejovine, a new antibiotic from the scorpion venom of Vaejovis mexicanus Toxicon, 57, 84-92.
Jimenez-Vargas,J.M. Restano-Cassulini,R. Quintero-Hernandez,V. Gurrola,G.B. Possani,L.D.
2011. Recombinant expression of the toxic peptide ErgTx1 and role of Met35 on its stability and function Peptides, 32, 560-567.
Gurrola,G.B. Capes,E.M. Zamudio,F.Z. Possani,L.D. Valdivia,H.H.
2010. Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca-Release Channels/Ryanodine Receptors Pharmaceuticals.(Basel), 3, 1093-1107.
Prestipino,G. Corzo,G. Romeo,S. Murgia,A.R. Zanardi,I. Gurrola,G. Possani,L.D.
2009. Scorpion toxins that block transient currents (IA) of rat cerebellum granular cells Toxicology Letters, 187, 1-9.
Aparicio-Fabre,R. Guillen,G. Estrada,G. Olivares-Grajales,J. Gurrola,G. Sanchez,F.
2006. Profilin tyrosine phosphorylation in poly-l-proline-binding regions inhibits binding to phosphoinositide 3-kinase in Phaseolus vulgaris Plant Journal, 47, 491-500.
Schiavon,E. Sacco,T. Restano-Cassulini,R. Gurrola,G. Tempia,F. Possani,L.D. Wanke,E.
2006. Resurgent current and voltage sensor-trapping enhanced activation by a {beta}-scorpion toxin solely in nav1.6 channel: Significance in Mice Purkinje Neurons Journal of Biological Chemistry, 281, 20326-20337.
Restano-Cassulini,R. Korolkova,Y.V. Diochot,S. Gurrola,G. Guasti,L. Possani,L. Lazdunski,M. Grishin,E. Arcangeli,A. Wanke,E.
2006. Species Diversity and Peptide Toxins Blocking Selectivity of ERG Subfamily K+ Channels in CNS Molecular Pharmacology, 69, 1673-1683.
Coronas,F.I. Balderas,C. Lopez,L.P. Possani,L.D. Gurrola,G.B.
2005. Amino acid sequence determination and chemical synthesis of CllErg1 (gamma-KTx1.5), a K+ channel blocker peptide isolated from the scorpion Centruroides limpidus limpidus Journal of the Brazilian Chemical Society, 16, 404-411.
Rosales-Castillo,J.A. Acosta-Saavedra,L.C. Torres,R. Ochoa-Fierro,J. Borja-Aburto,V.H. Lopez-Carrillo,L. Garcia-Vargas,G.G. Gurrola,G.B. Cebrian,M.E. Calderon-Aranda,E.S.
2004. Arsenic exposure and human papillomavirus response in non-melanoma skin cancer Mexican patients: a pilot study International Archives of Occupational and Environmental Health, 77, 418-423.
Frenal,K. Xu,C.Q. Wolff,N. Wecker,K. Gurrola,G.B. Zhu,S.Y. Chi,C.W. Possani,L.D. Tytgat,J. Delepierre,M.
2004. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K(+) channels Proteins, 56, 367-375.
Gazarian,T.G. Selisko,B. Gurrola,G.B. Possani,L.D. Gazarian,K.G.
2003. Potential of Peptides Selected from Random Phage-Displayed Libraries to Mimic Conformational Epitopes: A Study on Scorpion Toxin Cn2 and the Neutralizing Monoclonal Antibody BCF2 Combinatorial Chemistry & High Throughput Screening, 6, 119-132.
Corona,M. Gurrola,G.B. Merino,E. Cassulini,R.R. Valdez-Cruz,N.A. Garcia,B. Ramirez-Dominguez,M.E. Coronas,F.I. Zamudio,F.Z. Wanke,E. Possani,L.D.
2002. A large number of novel Ergtoxin-like genes and ERG K(+)-channels blocking peptides from scorpions of the genus Centruroides FEBS Letters, 532, 121-126.
Lecchi,M. Redaelli,E. Rosati,B. Gurrola,G. Florio,T. Crociani,O. Curia,G. Cassulini,R.R. Masi,A. Arcangeli,A. Olivotto,M. Schettini,G. Possani,L.D. Wanke,E.
2002. Isolation of a long-lasting eag-related gene-type K+ current in MMQ lactotrophs and its accommodating role during slow firing and prolactin release Journal of Neuroscience, 22, 3414-3425.
Pardo-Lopez,L. Garcia-Valdes,J. Gurrola,G.B. Robertson,G.A. Possani,L.D.
2002. Mapping the receptor site for ergtoxin, a specific blocker of ERG channels FEBS Letters, 510, 45-49.
Rocchetti,M. Besana,A. Gurrola,G.B. Possani,L.D. Zaza,A.
2001. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential Journal of Physiology, 534, 721-732.
Frau,A. Pisciotta,M. Gurrola,G.B. Possani,L.D. Prestipino,G.
2001. Synthetic undecapeptide (NTX10-20) of noxiustoxin blocks completely the I(A) potassium currents of cerebellum granular cells European Biophysics Journal, 29, 569-573.
Torres-Larios,A. Gurrola,G.B. Zamudio,F.Z. Possani,L.D.
2000. Hadrurin, a new antimicrobial peptide from the venom of the scorpion Hadrurus aztecus European Journal of Biochemistry, 267, 5023-5031.
Bottiglieri,C. Ferrara,L. Corona,M. Gurrola,G.B. Batista,C. Wanke,E. Possani,L.D.
2000. Disulfide bridges of ergtoxin, a member of a new sub-family of peptide blockers of the ether-a-go-go-related K+ channel FEBS Letters, 479, 156-157 Correction 481 (3) 308.
Zhu,X. Gurrola,G. Jiang,M.T. Walker,J.W. Valdivia,H.H.
1999. Conversion of an inactive cardiac dihydropyridine receptor II-III loop segment into forms that activate skeletal ryanodine receptors FEBS Letters, 450, 221-226 * .
Possani,L.D. Selisko,B. Gurrola,G.B.
1999. Structure and function of scorpion toxins affecting K+-channels Perspectives In Drug Discovery And Design, 16, 15-40.
Gurrola,G.B. Arevalo,C. Sreekumar,R. Lokuta,A.J. Walker,J.W. Valdivia,H.H.
1999. Activation of ryanodine receptors by imperatoxin A and a peptide segment of the II-III loop of the dihydropyridine receptor Journal of Biological Chemistry, 274, 7879-7886 * .
Gurrola,G.B. Rosati,B. Rocchetti,M. Pimienta,G. Zaza,A. Arcangeli,A. Olivotto,M. Possani,L.D. Wanke,E.
1999. A toxin to nervous, cardiac, and endocrine ERG K+ channels isolated from Centruroides noxius scorpion venom FASEB Journal, 13, 953-962.
Samso,M. Trujillo,R. Gurrola,G.B. Valdivia,H.H. Wagenknecht,T.
1999. Three-dimensional location of the imperatoxin A binding site on the ryanodine receptor Journal of Cell Biology, 146, 493-499 * .
Calderon-Aranda,E.S. Selisko,B. York,E.J. Gurrola,G.B. Stewart,J.M. Possani,L.D.
1999. Mapping of an epitope recognized by a neutralizing monoclonal antibody specific to toxin Cn2 from the scorpion Centruroides noxius, using discontinuous synthetic peptides European Journal of Biochemistry, 264, 746-755.
Martinez,F. Munoz-Garay,C. Gurrola,G. Darszon,A. Possani,L.D. Becerril,B.
1998. Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels FEBS Letters, 429, 381-384.
Olamendi-Portugal,T. Gomez-Lagunas,F.G. Gurrola,G.B. Possani,L.D.
1998. Two similar peptides from the venom of the scorpion Pandinus imperator, one highly effective blocker and the other inactive on K+ channels Toxicon, 36, 759-770.
Zamudio,F.Z. Gurrola,G.B. Arevalo,C. Sreekumar,R. Walker,J.W. Valdivia,H.H. Possani,L.D.
1997. Primary structure and synthesis of Imperatoxin A (IpTx(a)), a peptide activator of Ca2+ release channels/ryanodine receptors FEBS Letters, 405, 385-389.
Dehesa-Davila,M. Ramirez,A.N. Zamudio,F.Z. Gurrola-Briones,G. Lievano,A. Darszon,A. Possani,L.D.
1996. Structural and functional comparison of toxins from the venom of the scorpions Centruroides infamatus infamatus, Centruroides limpidus limpidus and Centruroides noxius Comparative Biochemistry and Physiology, 113, 331-339.
Olamendi-Portugal,T. Gomez-Lagunas,F. Gurrola,G.B. Possani,L.D.
1996. A novel structural class of K+-channel blocking toxin from the scorpion Pandinus imperator Biochemical Journal, 315, 977-981.
Nieto,A.R. Gurrola,G.B. Vaca,L. Possani,L.D.
1996. Noxiustoxin 2, a novel K+ channel blocking peptide from the venom of the scorpion Centruroides noxius Hoffmann Toxicon, 34, 913-922.
Martinez,F. Becerril,B. Gurrola,G.B. Martin,B.M. Possani,L.D.
1996. Synthesis and expression of the gene coding for noxiustoxin, a K+ channel-blocking peptide from the venom of the scorpion Centruroides noxius Toxicon, 34, 1413-1419.
Herion,P. Gurrola-Briones,G. Sanchez,M.D.R. Saavedra,R. Possani,L.D.
1995. Monoclonal antibodies against noxiustoxin Hybridoma, 14, 247-251.
Drakopoulou,E. Cotton,J. Virelizier,H. Bernardi,E. Schoofs,A.R. Partiseti,M. Choquet,D. Gurrola,G. Possani,L.D. Vita,C.
1995. Chemical synthesis, structural and functional characterisation of noxiustoxin, a powerful blocker of lymphocyte voltage-dependent K+ channels Biochemical and Biophysical Research Communications, 213, 901-907.
Gurrola,G.B. Possani,L.D.
1995. Structural and functional features of noxiustoxin: a K+ channel blocker.Biochemistry and Molecular Biology International, 37, 527-535.
Dauplais,M. Gilquin,B. Possani,L.D. Gurrola-Briones,G. Roumestand,C. Menez,A.
1995. Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins Biochemistry, 34, 16563-16573.
Gurrola,G.B. Moreno-Hagelsieb,G. Zamudio,F.Z. Garcia,M. Soberon,X. Possani,L.D.
1994. The disulfide bridges of toxin 2 from the scorpion Centruroides noxius Hoffmann and its three-dimensional structure calculated using the coordinates of variant 3 from Centruroides sculpturatus FEBS Letters, 347, 59-62.
Ramirez,A.N. Martin,B.M. Gurrola,G.B. Possani,L.D.
1994. Isolation and characterization of a novel toxin from the venom of the scorpion Centruroides limpidus limpidus Karsch Toxicon, 32, 479-490.
Martin,B.M. Ramirez,A.N. Gurrola,G.B. Nobile,M. Prestipino,G. Possani,L.D.
1994. Novel K(+)-channel-blocking toxins from the venom of the scorpion Centruroides limpidus limpidus Karsch Biochemical Journal, 304, 51-56.
Vaca,L. Gurrola,G.B. Possani,L.D. Kunze,D.L.
1993. Blockade of a KCa channel with synthetic peptides from noxiustoxin: a K+ channel blocker Journal of Membrane Biology, 134, 123-129.
Zamudio,F. Saavedra,R. Martin,B.M. Gurrola-Briones,G. Herion,P. Possani,L.D.
1992. Amino acid sequence and immunological characterization with monoclonal antibodies of two toxins from the venom of the scorpion Centruroides noxius Hoffmann European Journal of Biochemistry, 204, 281-292.
Possani,L.D. Martin,B.M. Yatani,A. Mochca-Morales,J. Zamudio,F.Z. Gurrola,G.B. Brown,A.M.
1992. Isolation and physiological characterization of taicatoxin, a complex toxin with specific effects on calcium channels Toxicon, 30, 1343-1364.
Gurrola,G.B. Molinar-Rode,R. Sitges,M. Bayon,A. Possani,L.D.
1989. Synthetic peptides corresponding to the sequence of noxiustoxin indicate that the active site of this K+ channel blocker is located on its amino-terminal portion Journal of Neural Transmission, 77, 11-20.
Martin,B.M. Carbone,E. Yatani,A. Brown,A.M. Ramirez,A.N. Gurrola,G.B. Possani,L.D.
1988. Amino acid sequence and physiological characterization of toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann Toxicon, 26, 785-794.
Ramirez,A.N. Gurrola,G.B. Martin,B.M. Possani,L.D.
1988. Isolation of several toxins from the venom of the scorpion Centruroides limpidus tecomanus Hoffmann Toxicon, 26, 773-783.
Brown,A.M. Yatani,A. Lacerda,A.E. Gurrola,G.B. Possani,L.D.
1987. Neurotoxins that act selectively on voltage-dependent cardiac calcium channels Circulation Research, 61, I6-I9.
Possani,L.D. Gurrola,G.B. Schwartz,E. Restano,R. 2011. Bioquimica y biologia molecular de los venenos de escorpiones de importancia medica en el continente americano en: Paniagua Solis,J.F. Emergencias por Animales Ponzonosos en las Americas. Mexico. Instituto Bioclon. pags. 147-180
Gurrola,G.B. Zhu,X. Valdivia,H. 2005. Scorpion Peptides as High-Affinity Probes of Ryanodine Receptor Function en: Marks,A.R. Ryanodine receptors : structure, function and dysfunction in clinical disease. New York. Springer. pags. 191-200
Gutierrez,M.C. Estrada,G.I. Estrada-Parra,S. Gurrola,G.B. Possani,L.D. 1991. Synthetic peptides as skin test reagents in leprosy en: Proceedings Leprosy Research in Latin America. Caracas. Instituto de Biomedicina. 7 p
Possani,L.D. Gurrola,G.B. Portugal,T.O. Zamudio,F.Z. Vaca,L.D. Calderon,S.A. Kirsch,G.E. 1991. Scorpion toxins: a model for peptide synthesis of new drugs en: Sgarbieri,V. Proceedings First Brazilian Congress on Proteins. Brasil. UNICAMP. pags. 352-367
Gurrola,G.B. Molina-Rode,R. Zentella,A.D. Possani,L.D. 1984. Sintesis de peptidos y su posible utilizacion como vacuna contra toxinas de alacran en: Barragan,L. Avances en el mecanismo de accion de farmacos. Masson de Mexico. pags. 35-50
Otras Publicaciones Sheard,T.M.D. Howlett,L. Kirton,H. Yang,Z. Gurrola,G. Steele,D. Jayasinghe,I. Valdivia,H.H. Colyer,J.
2020. Peptide ligands of the cardiac ryanodine receptor as super-resolution imaging probes bioRxiv, Preprint posted June 28, .
Patentes L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2012 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM México.
A. Alagón C., L. D. Possani P, G. Gurrola B., E. V. Grishin, A. V. Lipkin & K. E. Volynski 2010 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM Mexico.
L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2009 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM Europa 07734817.5,Estados Unidos 12/599,978, China 200780053305.7, Canadá CA 2686216, Australia 2007353147, Israel 202113, Euroasia 200901530, Corea 10-2009-7026000,Brasil (pendiente), Cuba 2009-0194, Japón (pendiente), India 7396/DELNP/2009,u Israel 202113, Corea 10-2009-7026000, y Singapur 200907395-8. (en trámite)
Georgina Gurrola Briones, Cynthia Annabel Hernández Aponte, Jesús Silva Sánchez, y Lourival Domingos Possani Postay 2009 Vejovina - Un péptido antibiótico.UNAM México. (en trámite)
L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2009 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM Sudáfrica.
M. Corona, M. C. García, N. A. Valdez, G. Gurrola, B. Becerril y L.D. Possani 2008 Recombinant Immunogens for the Generation of Antivenoms to the Venom of Scorpions of the Genus Centruroides .UNAM Estados Unidos.
L. D. Possani P., G. Gurrola-Briones, S. P. Salas-Castillo, C. V. Ferreira B., Z. S. Varga, G. Panyi y R. Gaspar 2007 Vm23 and Vm24, two scorpion peptides that block human-T-lymphocyte potassium channels (sub-type Kv1.3) with high selectivity and decrease the in vivo DTH-responses in rats.UNAM PCT. (en trámite)
M. Corona, M. C. García, N. A. Valdez, G. Gurrola, B. Becerril y L. D. Possani 2003 Inmunógenos recombinantes para la generación de antivenenos contra el veneno de alacranes del género Centruroides .UNAM México. (en trámite)
M. Corona, M. C. García, N. A. Valdez, G. Gurrola, B. Becerril y L. D. Possani 2002 Inmunógenos recombinantes para la generación de antivenenos contra el veneno de alacranes del género Centruroides .UNAM Estados Unidos. (en trámite)
G. Gurrola, A. Alagón C. L. D. Possani P., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2002 Immunogen, Anti-Venom and Vaccine Against the Venom of the Black Widow Spider.UNAM Estados Unidos, Europa EP00980069.9 y Canadá 2,397,731.
G. Gurrola B., A. Alagón C., L. D. Possani P., E. V. Grishin, A. V. Lipkin y K. E. Volynski 2000 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM PCT.
A. Alagón C., L. D. Possani P., G. Gurrola B., E. V. Grishin, A. V. Lipkin y K. E. Volynski 1999 Inmunógeno, anti-veneno y vacuna contra el veneno de la araña viuda negra.UNAM-Inst. de QuÍmica Bioorgánica México. (en trámite)
L.D. Possani P. G. Gurrola B. M.A.A. Bayón C. M. Sitges B. 1991 Procedimiento, diseño y síntesis para la obtención de péptidos sintéticos de estructura (Ax)N-(As)N-As, capaces de formar derivados beta-carbonilos para sustratos fluorogénicos de enzimas hidrolasas.UNAM México. (en trámite)
L D. Possani P. G. Gurrola B. M. A. A. Bayón C y M. Sitges B. 1990 Synthetic Noxiustoxin related peptides.UNAM Estados Unidos.
* Indica publicación con otra institución de adscripción
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