. Instituto de Biotecnologia UNAM

IBT-UNAM : Dra. Ma. Del Carmen Beltran Nuñez

Dra. Ma. Del Carmen Beltran Nuñez

Investigador
Tutor de Maestría y Doctorado
Nivel II del SNI
Grupo del Dr. Alberto Darszon

email: beltran @ibt.unam.mx
Teléfonos
Oficina +52 (777) 311-4900 ext 234

Laboratorio +52 (777) 329-1611
desde la CDMX 562-27611
red UNAM 27611
+52 (777) 311-4900 ext 234

- Licenciatura: Químico Farmacobiologo, Escuela de Químico-Farmacobiologo, UMSNH, Morelia, Mich. (1980)
- Maestría: en Ciencias Bioquímicas, CINVESTAV-IPN (1984)
- Doctorado: en Ciencias IBB-Bioquímica, Instituto de Fisiología Celular-UNAM, (1989)
- Mencion honorífica en el examen de Doctorado
- Medalla "Gabino Barreda"-UNAM, Doctorado
- Premio Marcos y Celia Maus por la mejor tesis de Doctorado en Investigacion Biomedica Basica (1995)
- en el Roche Institute of Molecular Biology, Nutley, N.J., E.U.A. (1989-1992)

Estudiantes

Jose Daniel Angeles

Erika Elena Zagal

Publicaciones recientes

Ramirez-Gomez,H.V. Jimenez-Sabinina,V. Velazquez-Perez M. Beltran,C. Carneiro,J. Wood,C.D. Tuval,I. Darszon,A. Guerrero,A. 2020. Sperm chemotaxis is driven by the slope of the chemoattractant concentration field Elife, 9, e50532.

Chavez,J.C. Vicens,A. Wrighton,D.C. Andrade-Lopez,K. Beltran,C. Gutierrez,R.M. Lippiat,J.D. Trevino,C.L. 2019. A cytoplasmic Slo3 isoform is expressed in somatic tissues Molecular Biology Reports, 46, 5561-5567.

Espinal-Enriquez,J. Priego-Espinosa,D.A. Darszon,A. Beltran,C. Martinez-Mekler,G. 2017. Network model predicts that CatSper is the main Ca2+ channel in the regulation of sea urchin sperm motility Scientific Reports, 7, 4236.

Arcos-Hernandez,C. Romero,F. Sanchez-Guevara,Y. Beltran,C. Nishigaki,T. 2016. FRET analysis using sperm-activating peptides tagged with fluorescent proteins reveals that ligand-binding sites exist as clusters Journal of Experimental Biology, 219, 508-515.

Garcia-Rincon,J. Darszon,A. Beltran,C. 2016. Speract, a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism Biochimica et Biophysica Acta (BBA), 1857, 415-426.

Beltran,C. Rodriguez-Miranda,E. Granados-Gonzalez,G. de De la Torre LG Nishigaki,T. Darszon,A. 2014. Zn induces hyperpolarization by activation of a K channel and increases intracellular Ca and pH in sea urchin spermatozoa Developmental Biology, 394, 15-23.

Vacquier,V.D. Loza-Huerta,A. Garcia-Rincon,J. Darszon,A. Beltran,C. 2014. Soluble adenylyl cyclase of sea urchin spermatozoa Biochimica et Biophysica Acta (BBA), 1842, 2621-2628.

Loza-Huerta,A. Vera-Estrella,R. Darszon,A. Beltran,C. 2013. Certain Strongylocentrotus purpuratus sperm mitochondrial proteins co-purify with low density detergent-insoluble membranes and are PKA or PKC-substrates possibly involved in sperm motility regulation Biochimica et Biophysica Acta (BBA), 1830, 5305-5315.

Darszon,A. Sanchez-Cardenas,C. Orta,G. Sanchez-Tusie,A.A. Beltran,C. Lopez-Gonzalez,I. Granados-Gonzalez,G. Trevino,C.L. 2012. Are TRP channels involved in sperm development and function? Cell and Tissue Research, 349, 749-764.

Orta,G. Ferreira,G. Jose,O. Trevino,C.L. Beltran,C. Darszon,A. 2012. Human spermatozoa possess a calcium-dependent chloride channel that may participate in the acrosomal reaction Journal of Physiology, 590, 2659-2675.

Darszon,A. Nishigaki,T. Beltran,C. Trevino,C.L. 2011. Calcium Channels in the Development, Maturation, and Function of Spermatozoa Physiological Reviews, 91, 1305-1355.

Martinez-Lopez,P. Trevino,C.L. de la Vega-Beltran,J.L. Blas,G.D. Monroy,E. Beltran,C. Orta,G. Gibbs,G.M. O'Bryan,M.K. Darszon,A. 2011. TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction Journal of Cellular Physiology, 226, 1620-1631.

de Blas,G.A. Darszon,A. Ocampo,A.Y. Serrano,C.J. Castellano,L.E. Hernandez-Gonzalez,E.O. Chirinos,M. Larrea,F. Beltran,C. Trevino,C.L. 2009. TRPM8, a versatile channel in human sperm PLoS ONE, 4, e6095.

Ardon,F. Rodriguez-Miranda,E. Beltran,C. Hernandez-Cruz,A. Darszon,A. 2009. Mitochondrial inhibitors activate influx of external Ca(2+) in sea urchin sperm Biochimica et Biophysica Acta (BBA), 1787, 15-24.

Darszon,A. Trevino,C.L. Wood,C. Galindo,B. Rodriguez-Miranda,E. Acevedo,J.J. Hernandez-Gonzalez,E.O. Beltran,C. Martinez-Lopez,P. Nishigaki,T. 2007. Ion channels in sperm motility and capacitation.Society of Reproduction and Fertility supplement, 65, 229-244.

Beltran,C. Galindo,B.E. Rodriguez-Miranda,E. Sanchez,D. 2007. Signal transduction mechanisms regulating ion fluxes in the sea urchin sperm Signal Transduction, 7, 103-117.

Beltran,C. Vacquier,V.D. Moy,G. Chen,Y. Buck,J. Levin,L.R. Darszon,A. 2007. Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction Biochemical and Biophysical Research Communications, 358, 1128-1135.

Darszon,A. Acevedo,J.J. Galindo,B.E. Hernandez-Gonzalez,E.O. Nishigaki,T. Trevino,C.L. Wood,C. Beltran,C. 2006. Sperm channel diversity and functional multiplicity Reproduction, 131, 977-988.

Granados-Gonzalez,G. Mendoza-Lujambio,I. Rodriguez,E. Galindo,B.E. Beltran,C. Darszon,A. 2005. Identification of voltage-dependent Ca(2+) channels in sea urchin sperm FEBS Letters, 579, 6667-6672.

Nomura,M. Beltran,C. Darszon,A. Vacquier,V.D. 2005. A soluble adenylyl cyclase from sea urchin spermatozoa Gene, 353, 231-238.

Darszon,A. Nishigaki,T. Wood,C. Trevino,C.L. Felix,R. Beltran,C. 2005. Calcium channels and ca(2+) fluctuations in sperm physiology International Review of Cytology, 243, 79-172.

Darszon,A. Wood,C.D. Beltran,C. Sanchez,D. Rodriguez,E. Gorelik,J. Korchev,Y.E. Nishigaki,T. 2004. Measuring ion fluxes in sperm Methods in Cell Biology, 74, 545-576.

Schulz,J.R. de la Vega-Beltran,J.L. Beltran,C. Vacquier,V.D. Darszon,A. 2004. Ion channel activity of membrane vesicles released from sea urchin sperm during the acrosome reaction Biochemical and Biophysical Research Communications, 321, 88-93.

Trevino,C.L. Serrano,C.J. Beltran,C. Felix,R. Darszon,A. 2001. Identification of mouse trp homologs and lipid rafts from spermatogenic cells and sperm FEBS Letters, 509, 119-125.

Darszon,A. Beltran,C. Felix,R. Nishigaki,T. Trevino,C.L. 2001. Ion Transport in Sperm Signaling Developmental Biology, 240, 1-14.

Galindo,B.E. Nishigaki,T. Rodriguez,E. Sanchez,D. Beltran,C. Darszon,A. 2000. Speract-receptor interaction and the modulation of ion transport in Strongylocentrotus purpuratus sea urchin sperm Zygote, 8, S20-S21.

Galindo,B.E. Beltran,C. Cragoe,E.J. Darszon,A. 2000. Participation of a K(+) channel modulated directly by cGMP in the speract-induced signaling cascade of strongylocentrotus purpuratus sea urchin sperm Developmental Biology, 221, 285-294.

Trevino,C.L. Santi,C.M. Beltran,C. Hernandez-Cruz,A. Darszon,A. Lomeli,H. 1998. Localisation of inositol trisphosphate and ryanodine receptors during mouse spermatogenesis: possible functional implications Zygote, 6, 159-172.

Lokuta,A.J. Darszon,A. Beltran,C. Valdivia,H.H. 1998. Detection and functional characterization of ryanodine receptors from sea urchin eggs Journal of Physiology, 510, 155-164.

Vazquez-Memije,M.E. Beltran,C. Tuena-de-Gomez-Puyou,M. 1997. Isolation and comparative studies of mitochondrial F1-ATPase from rat testis and beef heart Comparative Biochemistry and Physiology, 116, 303-309.

Zapata,O. Ralston,J. Beltran,C. Parys,J.B. Chen,J.L. Longo,F.J. Darszon,A. 1997. Inositol triphosphate receptors in sea urchin sperm Zygote, 5, 355-364.

Darszon,A. Lievano,A. Beltran,C. 1996. Ion channels: key elements in gamete signaling Current Topics in Developmental Biology, 34, 117-167.

Labarca,P. Santi,C. Zapata,O. Morales,E. Beltran,C. Lievano,A. Darszon,A. 1996. A cAMP regulated K+-selective channel from the sea urchin sperm plasma membrane Developmental Biology, 174, 271-280.

Beltran,C. Zapata,O. Darszon,A. 1996. Membrane potential regulates sea urchin sperm adenylylcyclase Biochemistry, 35, 7591-7598.

Sepulveda-Becerra,M.A. Ferreira,S.T. Strasser,R.J. Garzon-Rodriguez,W. Beltran,C. Gomez-Puyou,A. Darszon,A. 1996. Refolding of triosephosphate isomerase in low-water media investigated by fluorescence resonance energy transfer Biochemistry, 35, 15915-15922.

Labarca,P. Zapata,O. Beltran,C. Darszon,A. 1995. Ion channels from the mouse sperm plasma membrane in planar lipid bilayers Zygote, 3, 199-206.

Sepulveda-Becerra,M.A. Ferreira,S.T. Strasser,R. Garzon-Rodriguez,W. Beltran,C. Gomez-Puyou,A. Darszon,A. 1995. REASSOCIATION OF TRIOSEPHOSPHATE ISOMERASE IN REVERSE MICELLES MEASURED BY ENERGY-TRANSFER.Protein Engineering, 8, 22-22.

Darszon,A. Labarca,P. Beltran,C. Garcia-Soto,J. Lievano,A. 1994. Sea urchin sperm: an ion channel reconstitution study case Methods, 6, 37-50.

Lievano,A. Beltran,C. Zapata,O. Reynaud,E. de la Torre,L. Garcia-Soto,J. Labarca,P. 1993. Ion channels and sea urchin sperm physiology.Journal of Reproduction and Development, 39, 51-52.

Nelson,N. Beltran,C. Supek,F. Nelson,H. 1992. Cell biology and evolution of proton pumps Cell Physiol Biochem, 2, 150-158 * .

Beltran,C. Kopecky,J. Pan,Y.C. Nelson,H. Nelson,N. 1992. Cloning and mutational analysis of the gene encoding subunit C of yeast vacuolar H(+)-ATPase Journal of Biological Chemistry, 267, 774-779 * .

Beltran,C. Nelson,N. 1992. The membrane sector of vacuolar H(+)-ATPase by itself is impermeable to protons.Acta Physiologica Scandinavica, Supplement, 607, 41-47 * .

Supek,F. Supekova,L. Beltran,C. Nelson,H. Nelson,N. 1992. Structure, function, and mutational analysis of V-ATPases Annals of the New York Academy of Sciences, 671, 284-292 * .

Noumi,T. Beltran,C. Nelson,H. Nelson,N. 1991. Mutational analysis of yeast vacuolar H(+)-ATPase Proceedings of the National Academy of Sciences of the United States of America, 88, 1938-1942 * .

Beltran,C. Gomez-Puyou,A. Tuena-de-Gomez-Puyou,M. 1988. Binding of dicyclohexylcarbodiimide to a native F1-ATPase-inhibitor protein complex isolated from bovine heart mitochondria Biochemical and Biophysical Research Communications, 152, 867-873 * .

Beltran,C. Tuena-de-Gomez-Puyou,M. Darszon,A. Gomez-Puyou,A. 1986. Simultaneous synthesis and hydrolysis of ATP regulated by the inhibitor protein in submitochondrial particles European Journal of Biochemistry, 160, 163-168 * .

Beltran,C. de Gomez-Puyou,M.T. Gomez-Puyou,A. Darszon,A. 1984. Release of the inhibitory action of the natural ATPase inhibitor protein on the mitochondrial ATPase European Journal of Biochemistry, 144, 151-157 * .

Libros y capítulos recientes

Guerrero,A. Gadelha,H.(error para rghector) Ramirez,R. Beltran,C. Tuval,I. 2020. Chapter 12 Motility and Guidance of Sea Urchin Sperm en: Asturiano,J.F. Reproduction in Aquatic Animals: From Basic Biology to Aquaculture Technology. Singapore. Springer Singapore. pags. 249-276

Rodriguez-Tobon,A. Arenas-Rios,E. Beltran-Nunez,C. 2019. El papel de los epididimosomas en la transferencia de proteínas durante la maduración epididimaria en: El espermatozoide: Una mirada desde México. Oaxaca. Universidad "Benito Juárez" de Oaxaca, México. pags. 44-59

Rodriguez-Miranda,E. Acevedo-Fernandez,J.J. Negrete-Leon,E. Darszon,A. Beltran,C. 2019. Efecto de la aloxana en la reaccion acrosomal del espermatozoide de rata en: Investigacion en la Educacion Superior,: Morelia 2019. Memorias del Congreso Internacional de Investigación Academia Journals Morelia 2019, Morelia, Michoacán, México 15 al 17 de mayo de 2019. 214. pags. 2517-2521

Beltran-Nunez,C. 2019. Adenosina 3´,5´-monofosfato cíclico en la fisiología del espermatozoide del erizo de mar en: Fuentes-Mascorro,G. El espermatozoide: Una mirada desde México. Oaxaca. Universidad "Benito Juárez" de Oaxaca, México. pags. 60-100

Rodriguez-Miranda,E. Acevedo-Fernandez,J.J. Negrete-Leon,E. Darszon,A. Beltran,C. 2018. Expresión diferencial de proteínas en el espermatozoide de ratas diabéticas en: Memorias del Congreso Internacional de Investigación Academia Journals Celaya 2018 vol 28. pags. 4683-4688

Beltran,C. Trevino,C.L. Mata-Martinez,E. Chavez,J.C. Sanchez-Cardenas,C. Baker,M. Darszon,A. 2016. Role of Ion Channels in the Sperm Acrosome Reaction en: Buffone,M.G. Sperm Acrosome Biogenesis and Function During Fertilization. Springer International Publishing Switzerland. pags. 35-69

Darszon,A. Espinosa,F. Galindo,B. Sanchez,D. Beltran,C. 2002. Regulation of sperm ion currents en: Hardy,D. Fertilization. Nueva York, Londres, Tokio. Academic Press. pags. 225-264

Labarca,P. Santi,C. Zapata,O. Beltran,C. Lievano,A. Sandoval,Y. Darszon,A. 1997. 9 en: Saez,J.C. From ion channels to cell-to-cell conversations. New York. Plenum Press. pags. 147-168

Gomez-Puyou,A. Beltran,C. Darszon,A. de Gomez-Puyou,M.T. 1984. Modulation of the catalytic properties of the mitochondrial ATpase by its inhibitor protein en: Packer,L. H+-ATPase (ATP synthase)--structure, function, biogenesis : the F0F1 complex of coupling membranes. Bari. Published on behalf of the ICSU Press by Adriatica Editrice. pags. 397-409 *

Otras Publicaciones

Ramirez-Gomez,H.V. Jimenez-Sabinina,V. Tuval,I. Velazquez-Perez,M. Beltran,C. Carneiro,J. Wood,C. Darszon,A. Guerrero,A. 2017. Sperm chemotaxis is driven by the slope of the chemoattractant concentration field bioRxiv, preprint posted August 11, 2019., .

* Indica publicación con otra institución de adscripción