IBT-UNAM : M.C. Alejandro Olvera Rodriguez
M.C. Alejandro Olvera Rodriguez
Grupo del Dr. Alejandro Alagon
email: aolvera @ibt.unam.mx
Teléfonos
Oficina +52 (777) 311-4900 ext 294 Laboratorio +52 (777) 329-1602 red UNAM 27602 +52 (777) 311-4900 ext 294
Estudiantes Biol. Mitzi Guadalupe Amaro "Obtención de proteína soluble de la α-latrotoxina de Latrodectus mactans, a partir de cuerpos de inclusión en el modelo de Escherichia coli"
Biol. Nicolas Elizalde
Biol. Luis Fernando Losoya
Biol. Oscar Jesús Pérez "Expresión y caracerización de una alfa-neurotoxina presente en el veneno de la serpiente de coral M. browni."
Publicaciones recientes
Benard-Valle,M. Neri-Castro,E. Elizalde-Morales,N. Olvera-Rodriguez,A. Strickland,J. Acosta,G. Alagon,A.
2021. Protein composition and biochemical characterization of venom from Sonoran Coral Snakes (Micruroides euryxanthus) Biochimie, 182, 206-216.
Neri-Castro,E. Benard-Valle,M. Paniagua,D. Boyer,L.V. Possani,L.D. Lopez-Casillas,F. Olvera,A. Romero,C. Zamudio,F. Alagon,A.
2020. Neotropical Rattlesnake (Crotalus simus) Venom Pharmacokinetics in Lymph and Blood Using an Ovine Model Toxins (Basel), 12, 455.
Neri-Castro,E. Sanz,L. Olvera-Rodriguez,A. Benard-Valle,M. Alagon,A. Calvete,J.J.
2020. Venomics and biochemical analysis of the black-tailed horned pitviper, Mixcoatlus melanurus, and characterization of Melanurutoxin, a novel crotoxin homolog Journal of Proteomics, 225, 103865.
Benard-Valle,M. Neri-Castro,E.E. Yanez-Mendoza,M.F. Lomonte,B. Olvera,A. Zamudio,F. Restano-Cassulini,R. Possani,L.D. Jimenez-Ferrer,E. Alagon,A.
2020. Functional, proteomic and transcriptomic characterization of the venom from Micrurus browni browni: Identification of the first lethal multimeric neurotoxin in coral snake venom Journal of Proteomics, 225, 103863.
Rivas-Mercado E. Neri-Castro,E. Benard-Valle,M. Rucavado-Romero,A. Olvera-Rodriguez,A. Zamudio-Zuniga F. Alagon,A. Garza-Ocanas L.
2020. Disintegrins extracted from totonacan rattlesnake (Crotalus totonacus) venom and their anti-adhesive and anti-migration effects on MDA-MB-231 and HMEC-1 cells Toxicology in Vitro, 65, 104809.
Neri-Castro,E. Hernandez-Davila,A. Olvera-Rodriguez,A. Cardoso-Torres,H. Benard-Valle,M. Bastiaans,E. Lopez-Gutierrez,O. Alagon,A.
2019. Detection and quantification of a b-neurotoxin (crotoxin homologs) in the venom of the rattlesnakes Crotalus simus, C. culminatus and C. tzabcan from Mexico Toxicon X, 2, 100007.
Guerrero-Garzon,J.F. Benard-Valle,M. Restano-Cassulini,R. Zamudio,F. Corzo,G. Alagon,A. Olvera-Rodriguez,A.
2018. Cloning and sequencing of three-finger toxins from the venom glands of four Micrurus species from Mexico and heterologous expression of an alpha-neurotoxin from Micrurus diastema Biochimie, 147, 114-121.
Borja,M. Neri-Castro,E. Castaneda-Gaytan,G. Strickland,J.L. Parkinson,C.L. Castaneda-Gaytan,J. Ponce-Lopez,R. Lomonte,B. Olvera-Rodriguez,A. Alagon,A. Perez-Morales,R.
2018. Biological and Proteolytic Variation in the Venom of Crotalus scutulatus scutulatus from Mexico Toxins (Basel), 10, .
Calcines-Cruz,C. Olvera,A. Castro-Acosta,R.M. Zavala,G. Alagon,A. Trujillo-Roldan,M.A. Valdez-Cruz,N.A.
2018. Recombinant-phospholipase A2 production and architecture of inclusion bodies are affected by pH in Escherichia coli International Journal of Biological Macromolecules, 108, 826-836.
Valdez-Cruz,N.A. Reynoso-Cereceda,G.I. Perez-Rodriguez,S. Restrepo-Pineda,S. Gonzalez-Santana,J. Olvera,A. Zavala,G. Alagon,A. Trujillo-Roldan,M.A.
2017. Production of a recombinant phospholipase A2 in Escherichia coli using resonant acoustic mixing that improves oxygen transfer in shake flasks Microbial Cell Factories, 16, 129.
Jauregui-Zuniga,D. Pedraza-Escalona,M. Espino-Solis,G.P. Quintero-Hernandez,V. Olvera-Rodriguez,A. Diaz-Salinas,M.A. Lopez,S. Possani,L.D.
2017. Targeting antigens to Dec-205 on dendritic cells induces a higher immune response in chickens: Hemagglutinin of avian influenza virus example Research in Veterinary Science, 111, 55-62.
Olvera,F. Rosales,A. Olvera,A. Diaz,P. Sevcik,C. Salazar,V. Alagon,A. Hernandez,H. D'Suze,G.
2016. An efficient approach to clone and express active Neopladine 2, an anticancer peptide from Tityus discrepans scorpion venom Process Biochemistry, 51, 624-631.
Espino-Solis,G.P. Quintero-Hernandez,V. Olvera-Rodriguez,A. Calderon-Amador,J. Pedraza-Escalona,M. Licea-Navarro,A. Flores-Romo,L. Possani,L.D.
2015. Novel monoclonal antibody against alphaX subunit from horse CD11c/CD18 integrin Veterinary Immunology and Immunopathology, 164, 220-226.
Castellanos-Mendoza,A. Castro-Acosta,R.M. Olvera,A. Zavala,G. Mendoza-Vera,M. Garcia-Hernandez,E. Alagon,A. Trujillo-Roldan,M.A. Valdez-Cruz,N.A.
2014. Influence of pH control in the formation of inclusion bodies during production of recombinant sphingomyelinase-D in Escherichia coli Microbial Cell Factories, 13, 137.
Lanari,L.C. Olvera,A. Costa de Oliveira,V. Laskowicz,R.D. Boyer,L. Lago,N.R. Alagon,A. de Roodt,A.R.
2014. Intraspecific differences in the immunochemical reactivity and neutralization of venom from Argentinean Bothrops (Rhinocerophis) alternatus by specific experimental antivenoms Toxicon, 85, 31-45 [corrigendum vol 88 p 138].
Carbajal-Saucedo,A. Floriano,R.S. Belo,C.A. Olvera-Rodriguez,A. Alagon,A. Rodrigues-Simioni,L.
2014. Neuromuscular Activity of Micrurus laticollaris (Squamata: Elapidae) Venom in Vitro Toxins (Basel), 6, 359-370.
Carbajal-Saucedo,A. Lopez-Vera,E. Benard-Valle,M. Smith,E.N. Zamudio,F. de Roodt,A.R. Olvera-Rodriguez,A.
2013. Isolation, characterization, cloning and expression of an alpha-neurotoxin from the venom of the Mexican coral snake Micrurus laticollaris (squamata: elapidae) Toxicon, 66, 64-74.
Clement,H. Olvera,A. Rodriguez,M. Zamudio,F. Palomares,L.A. Possani,L.D. Odell,G.V. Alagon,A. Sanchez-Lopez,R.
2012. Identification, cDNA cloning and heterologous expression of a hyaluronidase from the tarantula Brachypelma vagans venom Toxicon, 60, 1223-1227.
Sarasa,L. Gallego,C. Monleon,I. Olvera,A. Canudas,J. Montanes,M. Pesini,P. Sarasa,M.
2010. Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing Neuroscience, 171, 1091-1101.
Hernandez-Salgado,K. Estrada,G. Olvera,A. Coronas,F.I. Possani,L.D. Corzo,G.
2009. Heterologous expressed toxic and non-toxic peptide variants of toxin CssII are capable to produce neutralizing antibodies against the venom of the scorpion Centruroides suffusus suffusus Immunology Letters, 125, 93-99.
de Roodt,A.R. Estevez-Ramirez,J. Litwin,S. Magana,P. Olvera,A. Alagon,A.
2007. Toxicity of two North American Loxosceles (brown recluse spiders) venoms and their neutralization by antivenoms Clinical Toxicology, 45, 678-687.
Dragulev,B. Bao,Y. Ramos-Cerrillo,B. Vazquez,H. Olvera,A. Stock,R.P. Alagon,A. Fox,J.W.
2007. Upregulation of cytokine expression in fibroblasts exposed to Loxosceles sphingomyelinase D: What is the trigger? Journal of Investigative Dermatology, 127, 1267-1268.
Dragulev,B. Bao,Y. Ramos-Cerrillo,B. Vazquez,H. Olvera,A. Stock,R. Algaron,A. Fox,J.W.
2007. Upregulation of IL-6, IL-8, CXCL1, and CXCL2 Dominates Gene Expression in Human Fibroblast Cells Exposed to Loxosceles reclusa Sphingomyelinase D: Insights into Spider Venom Dermonecrosis Journal of Investigative Dermatology, 127, 1264-1266.
Olvera,A. Ramos-Cerrillo,B. Estevez,J. Clement,H. de Roodt,A. Paniagua-Solis,J. Vazquez,H. Zavaleta,A. Salas-Arruz,M. Stock,R.P. Alagon,A.
2006. North and South American Loxosceles spiders: Development of a polyvalent antivenom with recombinant sphingomyelinases D as antigens Toxicon, 48, 64-74.
Ramos-Cerrillo,B. Olvera,A. Odell,G.V. Zamudio,F. Paniagua-Solis,J. Alagon,A. Stock,R.P.
2004. Genetic and enzymatic characterization of sphingomyelinase D isoforms from the North American fiddleback spiders Loxosceles boneti and Loxosceles reclusa Toxicon, 44, 507-514 [Correction TOXICON 46 (2): 241-241 AUG 2005].
Juarez,P. Sanchez-Lopez,R. Stock,R.P. Olvera,A. Ramos,M.A. Alagon,A.
2001. Characterization of the Ehrab8 gene, a marker of the late stages of the secretory pathway of Entamoeba histolytica Molecular and Biochemical Parasitology, 116, 223-228.
Stock,R.P. Olvera,A. Sanchez,R. Saralegui,A. Scarfi,S. Sanchez-Lopez,R. Ramos,M.A. Boffa,L.C. Benatti,U. Alagon,A.
2001. Inhibition of gene expression in Entamoeba histolytica with antisense peptide nucleic acid oligomers Nature Biotechnology, 19, 231-234.
Sanchez-Lopez,R. Gutierrez,A. Juarez,P. Olvera,A. Olvera,F. Ramos,M.A. Sanchez,R. Saralegui,A. Stock,R.P. Alagon,A.
2000. Molecular genetics of the secretory pathway in Entamoeba histolytica: an overview Archives of Medical Research, 31, S151-S152.
Stock,R.P. Olvera,A. Scarfi,S. Sanchez,R. Ramos,M.A. Boffa,L.C. Benatti,U. Landt,O. Alagon,A.
2000. Inhibition of neomycin phosphorotransferase expression in Entamoeba histolytica with antisense peptide nucleic acid (PNA) oligomers Archives of Medical Research, 31, S271-S272.
Vargas-Villarreal,J. Olvera-Rodriguez,A. Mata-Cardenas,B.D. Martinez-Rodriguez,H.G. Said-Fernandez,S. Alagon-Cano,A.
1998. Isolation of an Entamoeba histolytica intracellular alkaline phospholipase A(2) Parasitology Research, 84, 310-314.
Otras Publicaciones Olvera-Rodriguez,A. Alagon-Cano,A. Ramos-Cerrillo,B. Cardoso-Torres,H.M. Olvera-Rodriguez,F.
2007. La partitura de la araña violinista: Envenenamiento fatal Hypatia, 22, .
Olvera,A. Olvera,F. Vines,R.R. Recillas-Targa,F. Lizardi,P.M. Dhar,S. Bhattacharya,S. Petri,W.J. Alagon,A.
1997. Stable transfection of Entamoeba histolytica trophozoites by lipofection.Archives of Medical Research, 28 ., 49-51.
Alagon,A. Cortes,A. Olvera,F. Olvera,A. Gonzalez,A. Lizardi,P.M.
1996. Diseño y construcción de vectores para la transformación estable de Entamoeba histolytica.Gaceta médica de México, 132, 476-482.
Ortega-Pierres,G. Alagon,A. Cortes,A. Olvera,F. Olvera,A. Gonzalez,A. Lizardi,P. Berzunza-Cruz,M. Saavedra-Lira,E. Perez-Montfort,R. Velasco-Castrejon,O. Sotero-Delgado Dominguez,I. Becker,I. Hernandez,R. Martinez-Calvillo,S. Frixione,E. Ruiz,L. Santillan,M. Vega,L. Tejero,J.M. Undeen,A.H. Kretschmer,R.R. Herion,P. Saavedra,R. Yepez-Mulia,L.
1996. [Impact of new methodologies in the study of parasites].Gaceta Medica de Mexico, 132, 475-517.
Patentes A. Olvera, R. P. Stock, B. M. Ramos, R. Sánchez y A. Alagón 2007 Inmunógeno y anti-veneno contra el veneno de la araña violinista.UNAM-Silanes Ecuador sp-07-7362, Australia 2005280742, Brasil PI0514809-0, Estados Unidos 11/574,488, Colombia 03082717, Costa Rica sin número y México MX/2007/002425. (en trámite)
A. Olvera, R. P. Stock, B. M. Ramos, R. Sánchez y A. Alagón 2007 Inmunógeno y anti-veneno contra el veneno de la araÒa violinista.UNAM-Silanes Ecuador, Australia, Brasil , Estados Unidos, Colombia y México. (en trámite)
A. Olvera, R. P. Stock, B. M. Ramos y A. Alagón 2005 Inmunógeno y anti-veneno contra el veneno de la araña violinista.Copropiedad de la UNAM-Silanes Perú.
A. Olvera, R. P. Stock, B. M. Ramos, R. Sánchez y A. Alagón 2005 Inmunógeno y anti-veneno contra el veneno de la araña violinista.UNAM-Silanes PCT, Nacionales en Chile 2223-05, Argentina P050103622 y Venezuela 2005-001775. (en trámite)
A. Olvera, R. P. Stock, B. M. Ramos y A. Alagón 2004 Inmunógeno y anti-veneno contra el veneno de la araña violinista.Copropiedad de la UNAM-Silanes México. (en trámite)
Técnico Académico