IBT-UNAM : Dr. Jose Adelfo Escalante Lozada
Dr. Jose Adelfo Escalante Lozada Investigador
Tutor de Maestría y Doctorado
Nivel II del SNI
Presidente de la Mesa Directiva Nacional de la Sociedad Mexicana de Biotecnología y Bioingeniería 2018-2020
Grupo del Dr. Francisco Gonzalo Bolivar
email: adelfo @ibt.unam.mx
Teléfonos
Laboratorio +52 (777) 329-1601 desde la CDMX 562-27601 red UNAM 27601
- Licenciatura: en Biología, Fac. de Ciencias-UNAM (1992) - Maestría: en Biotecnología, Fac. de Química-UNAM (1994) - Doctorado: en Biotecnología, Fac. de Química-UNAM (2000)
» Premio Sergio Sánchez Esquivel a Protocolos de Tesis en Biotecnología y Bioingeniería en el nivel Doctorado al protocolo de tesis titulado "Ingeniería de proteínas para la obtención de una shikimato deshidrogenasa con menor inhibición por shikimato y mayor eficiencia catalítica" Sociedad Mexicana de Biotecnología y Bio México (2015) » Premio Sergio Sánchez Esquivel a Protocolos de Tesis en Biotecnología y Bioingeniería en el nivel Licenciatura al protocolo de tesis titulado "Análisis de las mutaciones desarrolladas en la cepa de Escherichia coli PB11 durante un proceso de evolución adaptativa" Sociedad Mexicana de Biotecnología y Bio México (2013) » Premio Alfredo Sánchez Marroquín a las Mejores Tesis en Biotecnología y Bioingeniería en el nivel Licenciatura a la tesis titulada "Efecto de la clonación del gen zwf sobre la producción de shikimato en la cepa de Escherichia coli PB12.SA22" Sociedad Mexicana de Biotecnología y Bio México (2013)
Estudiantes Lic. Prisciliano Perez
Lic. Marco Antonio Morales
M.C. Susy Beatriz Carmona
Q.F.B. Julián Torres
M.C. Fabian Moreno
Ing. Allison Vianey Valle
Biol. Daniel Rodríguez
Fernando Astudillo
Q. José Antonio Velázquez
Rubén Mendoza
Publicaciones recientes
Moreno-Avitia,F. Utrilla,J. Bolivar,F. Nogales,J. Escalante,A.
2020. Metabolic reconstruction of Pseudomonas chlororaphis ATCC 9446 to understand its metabolic potential as a phenazine-1-carboxamide-producing strain Applied Microbiology and Biotechnology, 104, 10119-10132.
Carmona,S.B. Flores,N. Martinez-Romero,E. Gosset,G. Bolivar,F. Escalante,A.
2020. Evolution of an Escherichia coli PTS(-) strain: a study of reproducibility and dynamics of an adaptive evolutive process Applied Microbiology and Biotechnology, 104, 9309-9325.
Chacon-Vargas,K. Torres,J. Giles-Gomez,M. Escalante,A. Gibbons,J.G.
2020. Genomic profiling of bacterial and fungal communities and their predictive functionality during pulque fermentation by whole-genome shotgun sequencing Scientific Reports, 10, 15115.
Alva,A. Sabido-Ramos,A. Escalante,A. Bolivar,F.
2020. New insights into transport capability of sugars and its impact on growth from novel mutants of Escherichia coli Applied Microbiology and Biotechnology, 104, 1463-1479.
Mota-Pacheco,L.E. Guadarrama-Mendoza,P.C. Salas-Coronado,R. Escalante,A. Montville,T.J. Valadez-Blanco,R.
2019. Adaptation of Bacillus licheniformis to molasses for improved production of a biofertilizer strain. Adaptación de Bacillus licheniformis a melazas para una producción mejorada de una cepa biofertilizante. Agrociencia, 53, 1183-1201.
Aguilar,C. Martinez-Batallar,G. Flores,N. Moreno-Avitia,F. Encarnacion,S. Escalante,A. Bolivar,F.
2018. Analysis of differentially upregulated proteins in ptsHIcrr(-) and rppH(-) mutants in Escherichia coli during an adaptive laboratory evolution experiment Applied Microbiology and Biotechnology, 102, 10193-10208.
Diaz-Quiroz,D.C. Cardona-Felix,C.S. Viveros-Ceballos,J.L. Reyes-Gonzalez,M.A. Bolivar,F. Ordonez,M. Escalante,A.
2018. Synthesis, biological activity and molecular modelling studies of shikimic acid derivatives as inhibitors of the shikimate dehydrogenase enzyme of Escherichia coli Journal of Enzyme Inhibition and Medicinal Chemistry, 33, 397-404.
Figueroa,L.M. Santos-Zea,L. Escalante,A. Gutierrez-Uribe,J.A.
2017. Mass Spectrometry-Based Metabolomics of Agave Sap (Agave salmiana) after Its Inoculation with Microorganisms Isolated from Agave Sap Concentrate Selected to Enhance Anticancer Activity Sustainability, 9, 2095-2095.
Moreno-Avitia,F. Lozano,L. Utrilla,J. Bolivar,F. Escalante,A.
2017. Draft Genome Sequence of Pseudomonas chlororaphis ATCC 9446, a Nonpathogenic Bacterium with Bioremediation and Industrial Potential Genome Announcements, 5, .
Garcia,S. Flores,N. de Anda,R. Hernandez,G. Gosset,G. Bolivar,F. Escalante,A.
2017. The Role of the ydiB Gene, Which Encodes Quinate/Shikimate Dehydrogenase, in the Production of Quinic, Dehydroshikimic and Shikimic Acids in a PTS- Strain of Escherichia coli Journal of Molecular Microbiology and Biotechnology, 27, 11-21.
Giles-Gomez,M. Sandoval-Garcia,J.G. Matus,V. Campos-Quintana,I. Bolivar,F. Escalante,A.
2016. In vitro and in vivo probiotic assessment of Leuconostoc mesenteroides P45 isolated from pulque, a Mexican traditional alcoholic beverage Springerplus, 5, 708.
Escalante,A. Lopez-Soto,D.R. Velazquez-Gutierrez,J.E. Giles-Gomez,M. Bolivar,F. Lopez-Munguia,A.
2016. Pulque, a Traditional Mexican Alcoholic Fermented Beverage: Historical, Microbiological, and Technical Aspects Frontiers in Microbiology, 7, 1026.
Martinez,J.A. Bolivar,F. Escalante,A.
2015. Shikimic Acid Production in Escherichia coli: From Classical Metabolic Engineering Strategies to Omics Applied to Improve Its Production Frontiers in Bioengineering and Biotechnology, 3, 145.
Aguilar,C. Flores,N. Riveros-McKay,F. Sahonero-Canavesi,D. Carmona,S.B. Geiger,O. Escalante,A. Bolivar,F.
2015. Deletion of the 2-acyl-glycerophosphoethanolamine cycle improve glucose metabolism in Escherichia coli strains employed for overproduction of aromatic compounds Microbial Cell Factories, 14, 194.
Carmona,S.B. Moreno,F. Bolivar,F. Gosset,G. Escalante,A.
2015. Inactivation of the PTS as a Strategy to Engineer the Production of Aromatic Metabolites in Escherichia coli Journal of Molecular Microbiology and Biotechnology, 25, 195-208.
Martinez-Rodriguez,J.C. De La Mora-Amutio,M. Plascencia-Correa,L.A. Audelo-Regalado,E. Guardado,F.R. Hernandez-Sanchez,E. Pena-Ramirez,Y.J. Escalante,A. Beltran-Garcia,M.J. Ogura,T.
2014. Cultivable endophytic bacteria from leaf bases of Agave tequilana and their role as plant growth promoters Brazilian Journal of Microbiology, 45, 1333-1339.
Riveros-McKay,F. Campos,I. Giles-Gomez,M. Bolivar,F. Escalante,A.
2014. Draft Genome Sequence of Leuconostoc mesenteroides P45 Isolated from Pulque, a Traditional Mexican Alcoholic Fermented Beverage Genome Announcements, 2, .
Torres-Rodriguez,I. Rodriguez-Alegria,M.E. Miranda-Molina,A. Giles-Gomez,M. Conca-Morales R. Lopez-Munguia,A. Bolivar,F. Escalante,A.
2014. Screening and characterization of extracellular polysaccharides produced by Leuconostoc kimchii isolated from traditional fermented pulque beverage Springerplus, 3, 583.
Diaz-Quiroz,D.C. Carmona,S.B. Bolivar,F. Escalante,A.
2014. Current perspectives on applications of shikimic and aminoshikimic acids in pharmaceutical chemistry Research and Reports in Medicinal Chemistry, 4, 35-46.
Rodriguez,A. Martinez,J.A. Flores,N. Escalante,A. Gosset,G. Bolivar,F.
2014. Engineering Escherichia coli to overproduce aromatic amino acids and derived compounds Microbial Cell Factories, 13, 126.
Porras-Dominguez,J.R. Avila-Fernandez,A. Rodriguez-Alegria,M.E. Miranda-Molina,A. Escalante,A. Gonzalez-Cervantes,R. Olvera,C. Lopez-Munguia,A.
2014. Levan-type FOS production using a Bacillus licheniformis endolevanase Process Biochemistry, 49, 783-790.
Cortes-Tolalpa,L. Gutierrez-Rios,R.M. Martinez,L.M. de Anda,R. Gosset,G. Bolivar,F. Escalante,A.
2014. Global transcriptomic analysis of an engineered Escherichia coli strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system during shikimic acid production in rich culture medium Microbial Cell Factories, 13, 28.
Licona-Cassani,C. Lara,A.R. Cabrera-Valladares,N. Escalante,A. Hernandez-Chavez,G. Martinez,A. Bolivar,F. Gosset,G.
2014. Inactivation of Pyruvate Kinase or the Phosphoenolpyruvate: Sugar Phosphotransferase System Increases Shikimic and Dehydroshikimic Acid Yields from Glucose in Bacillus subtilis Journal of Molecular Microbiology and Biotechnology, 24, 37-45.
Aguilar,C. Escalante,A. Flores,N. de Anda,R. Riveros-McKay,F. Gosset,G. Morett,E. Bolivar,F.
2012. Genetic changes during a laboratory adaptive evolution process that allowed fast growth in glucose to an Escherichia coli strain lacking the major glucose transport system BMC Genomics, 13, 385.
Escalante,A. Salinas-Cervantes A. Gosset,G. Bolivar,F.
2012. Current knowledge of the Escherichia coli phosphoenolpyruvate-carbohydrate phosphotransferase system: peculiarities of regulation and impact on growth and product formation Applied Microbiology and Biotechnology, 94, 1483-1494.
Sanchez-Gonzalez,M. Blanco-Gamez,A. Escalante,A. Valladares,A.G. Olvera,C. Roberto,P.
2011. Isolation and characterization of new facultative alkaphilic Bacillus flexus strains from maize processing waste water (nejayote) Letters in Applied Microbiology, 52, 413-419.
Escalante,A. Calderon,R. Valdivia,A. de Anda,R. Hernandez,G. Ramirez,O.T. Gosset,G. Bolivar,F.
2010. Metabolic engineering for the production of shikimic acid in an evolved Escherichia coli strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system Microbial Cell Factories, 9, 21.
Orencio-Trejo,M. Flores,N. Escalante,A. Hernandez-Chavez,G. Bolivar,F. Gosset,G. Martinez,A.
2008. Metabolic regulation analysis of an ethanologenic Escherichia coli strain based on RT-PCR and enzymatic activities Biotechnology for Biofuels, 1, 8.
Escalante,A. Giles-Gomez,M. Hernandez,G. Cordova-Aguilar,M.S. Lopez-Munguia,A. Gosset,G. Bolivar,F.
2008. Analysis of bacterial community during the fermentation of pulque, a traditional Mexican alcoholic beverage, using a polyphasic approach International Journal of Food Microbiology, 124, 126-134.
Martinez,K. de Anda,R. Hernandez,G. Escalante,A. Gosset,G. Ramirez,O.T. Bolivar,F.G.
2008. Coutilization of glucose and glycerol enhances the production of aromatic compounds in an Escherichia coli strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system Microbial Cell Factories, 7, 1.
Flores,N. Escalante,A. de Anda,R. Baez-Viveros,J.L. Merino,E. Franco,B. Georgellis,D. Gosset,G. Bolivar,F.
2008. New Insights into the Role of Sigma Factor RpoS as Revealed in Escherichia coli Strains Lacking the Phosphoenolpyruvate:Carbohydrate Phosphotransferase System Journal of Molecular Microbiology and Biotechnology, 14, 176-192.
Flores,N. Leal,L. Sigala,J.C. de Anda,R. Escalante,A. Martinez,A. Ramirez,O.T. Gosset,G. Bolivar,F.
2007. Growth Recovery on Glucose under Aerobic Conditions of an Escherichia coli Strain Carrying a Phosphoenolpyruvate:Carbohydrate Phosphotransferase System Deletion by Inactivating arcA and Overexpressing the Genes Coding for Glucokinase and Galactose Permease Journal of Molecular Microbiology and Biotechnology, 13, 105-116.
Trevino-Quintanilla,L.G. Escalante,A. Caro,A.D. Martinez,A. (error para richar) Puente,J.L. Bolivar,F. Gosset,G.
2007. The Phosphotransferase System-Dependent Sucrose Utilization Regulon in Enteropathogenic Escherichia coli Strains Is Located in a Variable Chromosomal Region Containing iap Sequences Journal of Molecular Microbiology and Biotechnology, 13, 117-125.
Flores,S. Flores,N. de Anda,R. Gonzalez,A. Escalante,A. Sigala,J.C. Gosset,G. Bolivar,F.
2005. Nutrient-Scavenging Stress Response in an Escherichia coli Strain Lacking the Phosphoenolpyruvate:Carbohydrate Phosphotransferase System, as Explored by Gene Expression Profile Analysis Journal of Molecular Microbiology and Biotechnology, 10, 51-63.
Flores,N. Flores,S. Escalante,A. de Anda,R. Leal,L. Malpica,R. Georgellis,D. Gosset,G. Bolivar,F.
2005. Adaptation for fast growth on glucose by differential expression of central carbon metabolism and gal regulon genes in an Escherichia coli strain lacking the phosphoenolpyruvate:carbohydrate phosphotransferase system Metabolic Engineering, 7, 70-87.
Flores,N. de Anda,R. Flores,S. Escalante,A. Hernandez,G. Martinez,A. Ramirez,O.T. Gosset,G. Bolivar,F.
2004. Role of Pyruvate Oxidase in Escherichia coli Strains Lacking the Phosphoenolpyruvate:Carbohydrate Phosphotransferase System Journal of Molecular Microbiology and Biotechnology, 8, 209-221.
Escalante,A. Rodriguez,M.E. Martinez,A. Lopez-Munguia,A. Bolivar,F. Gosset,G.
2004. Characterization of bacterial diversity in Pulque, a traditional Mexican alcoholic fermented beverage, as determined by 16S rDNA analysis Fems Microbiology Letters, 235, 273-279.
Escalante,A. Villegas,J. Wacher,C. Garcia-Garibay,M. Farres,A.
2002. Activity of the enzymes involved in the synthesis of exopolysaccharide precursors in an overproducing mutant ropy strain of Streptococcus thermophilus Fems Microbiology Letters, 209, 289-293 * .
Escalante,A. Wacher,C. Farres,A.
2001. Lactic acid bacterial diversity in the traditional Mexican fermented dough pozol as determined by 16S rDNA sequence analysis International Journal of Food Microbiology, 64, 21-31 * .
Escalante,A. Wacher-Rodarte,C. Garcia-Garibay,M. Farres,A.
1998. Enzymes involved in carbohydrate metabolism and their role on exopolysaccharide production in Streptococcus thermophilus Journal of Applied Microbiology, 84, 108-114 * .
Libros y capítulos recientes
Escalante,A. Lopez-Soto,D.R. Velazquez-Gutierrez,J.E. Giles-Gomez,M. Bolivar,F. Lopez-Munguia,A. 2019. Pulque, a Traditional Mexican Alcoholic Fermented Beverage: Historical, Microbiological, and Technical Aspects [reimpresión Front Microbiol. 2016 Jun 30;7:1026] en: Shin,D.H. Microbiology of Ethnic Fermented Foods and Alcoholic Beverages of the World.. Lausanne. Frontiers Media.
Gutierrez-Uribe,J.A. Figueroa,L.M. Martin-del-Campo,S.T. Escalante,A. 2017. Pulque Chapter 23 en: Penas,E. Fermented Foods in Health and Disease Prevention. Boston. Academic Press. pags. 543-556
Moreno-Terrazas,R. Escalante,A. Verdugo-Valdez,A.G. de la Rosa,M. Ortiz-Basurto,R.I. Orantes-Garcia,C. Palafoz-Gonzalez,L. Castro-Diaz,A.S. Lappe-Oliveras,P. 2017. Bebidas Tradicionales y Nuevas Alternativas. Sección I. Bebidas refrescantes y alcohólicas de agave en: Gschaedler-Mathis,A.C. Panorama del aprovechamiento de los agaves en México. Zapopan. Red Temática Mexicana Aprovechamiento Integral Sustentable y Biotecnología de los Agaves. pags. 123-163
Escalante-Lozada,A. Giles-Gomez,M. Gosset-Lagarda,G. 2014. El pulque, una bebida histórica con importantes implicaciones biotecnológicas en: Rebolledo,F. Un Mundo de Bacterias. UNAM, Campus Morelos. pags. 91-95
Escalante,A. Giles-Gomez,M. Esquivel-Flores,G. Matus-Acuna,V. Moreno-Terrazas,R. Lopez-Munguia,A. Lappe-Oliveras,P. 2012. Pulque fermentation en: Evranuz,O. Handbook of Plant-Based Fermented Food and Beverage Technology, Second Edition. CRC Press. pags. 691-706
Escalante,A. Martinez,A. Rivera,M. Gosset,G. 2009. Section 1 en: Smolke,C.D. Metabolic Pathway Engineering Handbook. CRC Press. pags. 10-20
Otras Publicaciones
Mendoza-Flores,R. Diaz-Quiroz,D. Sabido-Ramos,A. Bolivar,F. Escalante,A.
2020. Ingeniería de vías metabólicas en bacterias para la producción de intermediarios de interés industrial de la vía del aminoshikimato Biotecnologia, 24, 11-28.
Alva,A. Bolivar,F. Escalante,A.
2017. Evaluación de Pseudomonas chlororaphis como nuevo modelo para la producción de ácido shikímico. Biotecnologia, 21, 66-79.
Escalante-Lozada,A.
2017. ¿Probióticos en el pulque? Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 9, 26-28.
Diaz,D.C. Bolivar,F. Escalante,A.
2016. Ingeniería de Proteínas Como una Herramienta en Ingeniería de Vías Metabólicas Biotecnologia, 20, 16-34.
Escalante-Lozada,A.
2015. ¿Por qué el pulque es viscoso? Biotecnología en Movimiento.Revista de divulgación del Instituto de Biotecnología de la UNAM, 2, 5-6.
Carmona,S. Bolivar,F. Escalante,A.
2013. Efecto de la Clonación del Gen zwf sobre la Producción de Shikimato en la Cepa de Escherichia coli PB12.SA22 Biotecnologia, 17, 66-86.
Cortes-Tolalpa,L. Carmona,S.B. Cervantes-Salinas,A. Garcia,M.A. Gosset,G. Escalante,A. Bolivar,F.
2011. Ingeniería de vías metabólicas en Escherichia coli para la producción de Shikimato como precursos para la síntesis de compuestos antivirales contra influenza. Biotecnologia, 15, 30-47.
Escalante,A. Valdivia,A. Gosset,G. Bolivar,F.
2009. Ingeniería de Vías Metabólicas en Escherichia Coli Pts– para la Obtención de Cepas Sobreproductoras de Shikimato Mensaje Bioquimico, 33, 171-180.
Escalante-Lozada,A. Gosset-Lagarda,G. Martinez-Jimenez,A. Bolivar-Zapata,F.
2004. Soil bacterial diversity: Microbial culture-independent methods of study and biotechnological implications Agrociencia, 38, 583-592.
Escalante,A.
2001. El potencial de la manipulacion de la flora intestinal por medios dieteticos sobre la salud humana Enfermedades Infecciosas y Microbiologia, 21, 106-114 * .
* Indica publicación con otra institución de adscripción